Personalized Treatment of 6-Mercaptopurine in Thai Children with Acute Lymphoblastic Leukemia

Pharmacogenetics of 6-Mercaptopurine

  • Jassada Buaboonnam Division of Hematology/Oncology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
  • Kleebsabai Sanpakit Division of Hematology/Oncology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
  • Trai Tharnpanich Division of Hematology/Oncology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThaiLand
Keywords: 6-mercaptopurine, lymphoblastic leukemia, TPMT

Abstract

Thanks to its ability to inhibit deoxyribonucleic acid synthesis, 6-mercaptopurine (6-MP), is one of the indispensable medications for acute lymphoblastic leukemia (ALL) patients. Nevertheless, some patients may succumb to myelotoxicity, leading to treatment disruption or even life-threatening events. Owing to the advances in pharmacogenomics, the genetic polymorphism of genes regulating purine synthesis has been identified and physicians can adjust the dose of 6-MP according to each polymorphism. Such polymorphisms genetically vary among ethnicities. In this article, 2 genetic polymorphisms, namely thiopurine methyltransferase and Nudix (nucleoside diphosphate linked moiety X) type motif 15, are clinically discussed, with a special focus on the clinical studies in Thai children with ALL.

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Published
2021-03-12
How to Cite
1.
Buaboonnam J, Sanpakit K, Tharnpanich T. Personalized Treatment of 6-Mercaptopurine in Thai Children with Acute Lymphoblastic Leukemia: Pharmacogenetics of 6-Mercaptopurine. PSU Med J [Internet]. 2021Mar.12 [cited 2021May14];1(1):23-7. Available from: https://he01.tci-thaijo.org/index.php/PSUMJ/article/view/245994
Section
Review Articles