Aged-match Comparison of Cutaneous Manifestation between Thai Male and Female Systemic Lupus Erythematous Patients at Maharaj Nakorn Si Thammarat Hospital: A Ten-year retrospective study
Keywords:
Systemic lupus erythematosus, TEN-like ACLE, seizureAbstract
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that affect multiple organ system. According to EULAR/ACR criteria 2019, a latest diagnostic criteria, the prevalence of each domain between male and female is varied. Knowing these difference can help the physicians focus on what they should looking for.
Objectives: The primary outcome is to compare the mucocutaneous domain in Male lupus with an age-matched female patients at Maharaj Nakhon Si Thammarat Hospital in the past 10 years, and to compare other domains as the secondary outcome.
Material and Method: A retrospective chart review of SLE patients aged above 18 at Maharaj Nakhon Si Thammarat Hospital from 1st January 2012 – 31st December 2021.
Results: 41 Male lupus patients with fulfil criteria from data records were identified together with age-matched 41 females. No significant difference between both groups in mucocutaneous domain and other clinical or laboratory domains. However, Male lupus patients tended to have seizure more than females (12.2 vs 2.4%, P = 0.09). Interestingly, an acute cutaneous lupus in term of TEN-like ACLE manifestation was found in male patients up to 30%.
Conclusion: Doctor should be aware of seizure, and differentiate between TEN-like ACLE and SJS/TEN especially in male lupus patients.
Keyword: Systemic lupus erythematosus, TEN-like ACLE, seizure
References
Wallace D, Hahn B. Dubois' lupus erythematosus and related syndromes. 9thed. Philadelphia: Elsevier Saunders; 2018.
Renau AI, Isenberg DA. Male versus female lupus: a comparison of ethnicity, clinical features, serology and outcome over a 30 year period. Lupus 2012;21:1041-8.
Murphy G, Isenberg D. Effect of gender on clinical presentation in systemic lupus erythematosus. Rheumatology (Oxford) 2013;52:2108-15.
Crosslin KL, Wiginton KL. Sex differences in disease severity among patients with systemic lupus erythematosus. Gend Med 2011;8:365-71.
Sherif Z. Yacoub W. Gender Differences in Systemic Lupus Erythematosus. Gend Med 2004;1:12-7.
Kanda N, Tsuchida T, Watanabe T, Tamaki K. Clinical features of systemic lupus erythematosus in men. Characteristics of the cutaneous manifestations. Dermatology 1996;193:6-10.
Deesomchok U, Tumrasvin T. Clinical features of systemic lupus erythematosus in Thai males and females. J Med Assoc Thai 1992;75:133-40.
Mongkoltanatus J, Wangkaew S, Kasitanon N, Louthrenoo W. Clinical features of Thai male lupus: an age-matched controlled study. Rheumatol Int 2008;28:339-44.
Tangtanatakul P, Thumarat C, Satproedprai N, Kunhapan P, Chaiyasung T, Klinchanhom S, et al. Meta-analysis of genome-wide association study identifies FBN2 as a novel locus associated with systemic lupus erythematosus in Thai population. Arthritis Res Ther 2020;22:185.
Satapornpong P, Jinda P, Jantararoungtong T, Koomdee N, Chaichan C, t Pratoomwun J, et al. Genetic Diversity of HLA Class I and Class II Alleles in Thai Populations: Contribution to Genotype-Guided Therapeutics. Front Pharmacol 2020;11:78.
Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Ann Rheum Dis 2019;78:1151-9.
Johnson SR, Brinks R, Costenbader KH, Daikh D, Mosca M, Goldman RR, et al. Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities. Ann Rheum Dis 2020;79:1333-9.
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เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในมหาราชนครศรีธรรมราชเวชสาร ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใด ๆ
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในมหาราชนครศรีธรรมราชเวชสาร ถือเป็นลิขสิทธิ์ของมหาราชนครศรีธรรมราชเวชสาร หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใด จะต้องได้รับอนุญาตเป็นลายลักษณ์อักษรจากวารสารมหาราชนครศรีธรรมราชเวชสาร ก่อนเท่านั้น
