Result of Nasopharyngeal Carcinoma Treatment in Maharaj Nakhon Si Thammarat Hospital
Keywords:
nasopharyngeal carcinoma, nasopharyngeal carcinoma treatment outcome, overall survival rate, recurrence rateAbstract
Background: Nasopharyngeal Carcinoma was a common malignancy in Southeast Asia. In Thailand, Second most common following oral cavity carcinoma.Most treatments are radiation therapy and chemotherapy. Maharaj Nakhon Si Thammarat Hospital has a machine for radiation therapy since 29 January 2019, but no patient data and treatment outcomes of nasopharyngeal carcinoma have been reported.
Objective: The aim of this study was to assess the outcomes of the treatment of nasopharyngeal carcinoma, including overall survival and recurrence rates.
Material and Methods: Medical records of patients with nasopharyngeal carcinoma who were treated at the hospital from 29 January 2019 to 29 January 2022 were retrospectively reviewed. There were four protocols of treatment including RT alone, CCRT, CCRT then adjuvant CCRT, induction CCRT +-adjuvant CMR. Select the treatments by NCCN guideline. Their characteristics were analyzed using descriptive statistics. Overall survival and recurrence rates were analyzed using survival analysis, and the factors affecting rates were analyzed using Spearman correlation analysis.
Results: 42 patients met the inclusion criteria and were recruited to this study. Majority of them were male (78.57%) average age is 53.71 with the age of more than or equal to 50 years (33.33% each group), BMI less than 23k g/m2. Patients mostly had poorly differentiated SCCA type of cancer cell (47.62%). Most patients came to the hospital with stage 3 cancer (50%) and with chief complaint of lymph node enlargement (54.76%). The results indicated that overall survival rate was 90.47% and recurrence rate was 7.14%. The factors associated with overall survival were stage of disease, while the factor associated with recurrence was patient’s underlying disease and stage of disease.
Conclusion: During 3 years of completed process of treatment (oral preparation chemotherapy and radiation therapy; VMAT) at Maharaj Nakhon Si Thammarat Hospital, the results of treatment were considerably satisfying maybe because of fast and convenient process, including overall survival rate and recurrence rates, compared to other studies. Additionally, patient’s stage of cancer was associated with both overall survival and recurrence, while their underlying disease was correlated with recurrence rate.
Keyword: nasopharyngeal carcinoma, nasopharyngeal carcinoma treatment outcome, overall survival rate, recurrence rate
References
Flint PW, Haughey BH, Lund VJ, Niprako JK, Robbins KT, Thomas JR, et al. Cummings otolaryngology head and neck surgery. 6thed. Philadelphia: Elsevier Inc; 2015.
พนา กล่ำคำ, รุตติ ชุมทอง, จเร เกียรติศิริชัย, สุพิชา วงษ์พูล, ไนยรัฐ ประสงค์สุข,ธีรยสถ์นิมมานนท์ และคณะ. อัตราการรอดชีวิตของผู้ป่วยมะเร็งหลังโพรงจมูกในโรงพยาบาลพระมงกุฎเกล้า ระหว่าง พ.ศ. 2552-2560. เวชสารแพทย์ทหารบก 2561; 71(4): 235-43.
Stelow EB, Wenig BM. Update From The 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Nasopharynx. Head and Neck Pathol 2017; 11: 16–22.
Wang W, Feng M, Fan Z, Li J, Lang J. Clinical outcome and prognostic factors of 695 nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy. Biomed Res Int 2014; 2014: 1-10.
Siti-Azrin AH, Norsaadah B, Naing NN. Prognostic factors of nasopharyngeal carcinoma patients in a tertiary referal hospital: a restrospective cohort study. BMC rest Notes 2017; 10: 705.
Pfister DG, Spencer S, Delstein DA, Adkins D, Brizel DM, Bruce JY. et al. NCCN guideline version 1.2021 Head and Neck Cancers National comprehensive cancer network. 2020.
Ch’ ng WPP, Law KB, Khoo JYY. Nasopharyngeal carcinoma: A retrospective review of outcome in asingle institution. Ann Oncol 2019; 30: ix100.
Huang TL, Tsai MH, Chuang HC, Chien CY, Lin YT, Tsai WL, et al. Quality of life and survival outcome for patients with nasopharyngeal carcinomatreated by volumetric-modulated arctherapy versus intensity-modulatedradiotherapy. Radiation Oncology 2020: 1-9.
Dou H, Hu D, Lam C, Liu Y, Wang X, Zhang W. Retrospective analysis of result of treatments for nasopharygeal carcinoma in Macao. Chin J Cancer Res 2014; 26(2): 148-58.
Clement A, Hao R, Xiaofeng W, Xue JZ, Sha L, Ping Z, et al. Retrospective Analysis of 5-Year Survival Rate of Nasopharyngeal Carcinoma:Correlation with Clinical Features and Prognosis. J Cancer Res Therap Oncol 2019; 7: 1-16.
Mäkitie A, Ruuskanen M, Bentzen J, Brun E, Gebre-Medhin M, Friesland S, et al.The management and survival outcomes ofnasopharyngeal cancer in the Nordic countries. Acta Oncologica 2018; 57(4): 557-62.
AbdElW SA, Mohammed DA, Gaballah AM, Abdallah MM. Three-Dimensional Conformal versus Intensity Modulated Radiation Therapy inTreatment of Nasopharyngeal Carcinoma. Egypt J Hosp Med 2018; 71: 3492-9.
Simo R, Robinson M, Lei M, Sibtain A, Hickey S.Nasopharyngeal carcinoma: United kingdom national multidisciplinary guidelines. The journal of laryngology&otology 2016; 130: S97-103.
Ni W, Qi W, Xu F, Cao W, XuCh, Gao Y, et al. Prognostic value of nasopharynxtumour volume in local-regional advanced nasopharyngeal carcinoma. ATM 2020; 8(5): 1-11
Farias TP, Dias FL, Lima RA, Kligerman R, Da sa GM, Barbosa MM, et al. Prognosis factor and outcome for nasopharyngeal carcinoma. Arch otolaryngol head neck surg 2003; 129: 794-9.
พรเทพ เกษมศิริ, คัททียา รองทอง, กฤติกา สุวรรณรุ่งเรือง. อัตราการรอดชีวิตในการรักษามะเร็งหลังโพรงจมูกในโรงพยาบาลศรีนครินทร์: ศึกษาย้อนหลัง 10 ปี. ศรีนครินทร์เวชสาร 2558; 30(2): 80-6.
Wu L, Liu Y, Jiang N, Fan Y, Wen J, Huang Sh. Ten-year survival outcomes for patients with nasopharyngeal carcinoma receiving intensity-modulated radiotherapy: An analysis of 614 patients from a single center. Oral Oncol 2017; 69: 26-32.
Susanna HH, Daniel H, Kartika WT, Mardiah SH, Ibnu P, IbnuRI. Survival outcome and prognostic factors of patients with nasopharyngeal cancer in Yogyakarta, Indonesia: A hospital-based retrospective study. PLOS One 2021; 1-20.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในมหาราชนครศรีธรรมราชเวชสาร ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใด ๆ
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในมหาราชนครศรีธรรมราชเวชสาร ถือเป็นลิขสิทธิ์ของมหาราชนครศรีธรรมราชเวชสาร หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใด จะต้องได้รับอนุญาตเป็นลายลักษณ์อักษรจากวารสารมหาราชนครศรีธรรมราชเวชสาร ก่อนเท่านั้น
