Case report: Antacid Tablets Residue were Foundin Gastrointestinal Tract
Keywords:
Antacid tablet, Chewable tablets, Intestinal obstruction, Antacid tablet, Chewable tablets, Intestinal obstructionAbstract
A lot of chewable antacid tablets were found in the small intestines of a 14-year-old male patient. He wasadmitted at Maharaj Nakhon Si Thammarat Hospital with abdominal pain, nausea, vomiting, constipation and anorexia. From patient interview and history taking found that a patient took antacid tablets without chewingevery meal continuingfor several days.Resulting the antacid tablets were not disintegrated in the patient's gastrointestinal tract.The factors that making the antacid tablets were not disintegrated might be due to the properties of pharmaceutical manufacturing were difficult to disintegratein the stomach. A co-factor might be the physiology of patient's gastrointestinal tract which caused the antacid tablets not to disintegrate and remained in the gastrointestinal tract for several days.
References
2. Nasri B, Calin M, Shah A, Gilchrist B. A rare cause of small bowel obstruction due to bezoar in a virgin abdomen. Int J Surg Case Rep. [Online] 2016 [cited 2021 Jan 21];19:144-146. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756184/
3. Iwamuro M, Okada H, Matsueda K, et al. Review of the diagnosis and management of gastrointestinal bezoars. World J Gastrointest Endosc. [Online] 2015[cited 2021 Jan21];7(4):336-345. Available from: https://pubmed.ncbi.nlm.nih.gov/25901212/
4. Jain SA, Agarwal L, Khyalia A, Chandolia P, Kaknale H. Pharmacobezoar-a rare case presented as gastric outlet obstruction. Journal of Surgical Case Reports.[Online]2018[cited 2021 Jan 25];2018(5):rjy116. Available from:https://academic.oup.com/jscr/ article/2018/5/ rjy116/5017811
5. Paschos KA, Chatzigeorgiadis A. Pathophysiological and clinical aspects of thediagnosis and treatment of bezoars. Annals of Gastroenterology. [Online] 2019 [cited 2021 Jan 25];32(3):224-232. Available from:https://pubmed.ncbi.nlm.nih.gov /31040619/
6. Parker V, Goldberg D, King MA. Case 1: Mysteriously Rising Salicylate Levels in a 15-year-old Girl. Pediatr Rev. [Online] 2017 [cited 2021 Jan 25] ;38(6):280-281. Available from:https://pubmed.ncbi.nlm.nih.gov/28572137/
7. U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). Quality Attribute Considerations for Chewable Tablets Guidance for Industry. [Online] 2018 [cited 2021 Jan 25];[16screens]. Available from:https://www.fda.gov/files/drugs/published/Quality-Attribute-Considerations-for-Chewable-Tablets-Guidance-for-Industry.pdf
8. Michele TM, Knorr B, Vadas EB, Reiss TF. Safety of chewable tablets form children. JAsthma. [Online] 2002[cited 2021 Feb 10];39(5):391-403. Available from:https://pubmed.ncbi.nlm.nih .gov/12214893/
9. United States Pharmacopeia and National Formulary (USP 41-NF 36). United States Pharmacopeial Convention; 2016.
10. Potyk D. Intestinal obstruction from impacted antacid tablets. N Engl J Med. [online] 2016 [cited 2021 Jan 30]; 1970;283:134–5. Available from; https://doi.org/10.1056/ NEJM 197007162830306.
11. Nasser N, Samantha N, Kennedy O. Chewable Antacid Tablets: Are Disintegration Test Relevant?.AAPS PharmSciTech. [online] 2016 [cited 2021 Jan 31]; 2020;21-139. Available from:https://link.springer.com/article/10.1208/s12249-020-01696-y.
12. Shin JM, Kim N. Pharmacokinetics and pharmacodynamics of the proton pump inhibitors. J Neurogastroenterol Motil.[Online] 2013 [cited 2021 Feb 10];19(1):25-35. Available from:http://www.jnmjournal.org/journal/view.html?uid=314&vmd=Full&
13. Clark K, Lam LT, Gibson S, Currow D. The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials. Anaesthesia. [Online] 2009 [cited 2021 Feb 10];64(6):652-657. Available from:https://pubmed.ncbi. nlm.nih.gov/19453319/
14. Achour L, Méance S, Briend A. Comparison of gastric emptying of a solid and a liquid nutritional rehabilitation food. Eur J Clin Nutr. [Online] 2001 [cited 2021 Feb 10];55(9):769-772. Available from:https://pubmed.ncbi.nlm.nih.gov/11528491/
15. Kurt A, Altun A, Bağcivan I, et al. Effects of proton pump inhibitors and h(2) receptor antagonists on the ileum motility. Gastroenterol Res Pract. [Online] 2011[cited 2021 Feb 10];2011:218342. Available from: https://pubmed.ncbi.nlm.nih.gov/22216022/
Downloads
Published
How to Cite
Issue
Section
License
เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในมหาราชนครศรีธรรมราชเวชสาร ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใด ๆ
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในมหาราชนครศรีธรรมราชเวชสาร ถือเป็นลิขสิทธิ์ของมหาราชนครศรีธรรมราชเวชสาร หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใด จะต้องได้รับอนุญาตเป็นลายลักษณ์อักษรจากวารสารมหาราชนครศรีธรรมราชเวชสาร ก่อนเท่านั้น
