Peritoneal Dialysis Related Fungal Peritonitis in Maharaj Nakhon Si Thammarat Hospital: A 10-years Single-Centre Experience

Abstract

Background: Fungal peritonitis is a serious complication of peritoneal dialysis (PD) therapy. The aims of this study were to identify risk factors and clinical associations. Therefore, important in planning and planning measures to prevent future fungal infections.

Objective: To study the rate of fungal peritonitis, identify risk factors and clinical associations with fungal peritonitis in peritoneal dialysis patient at Maharaj Nakhon Si Thammarat Hospital, dating back 10 years.

Materials and Methods: A retrospective for a period of 10 years by collected data from medical records of end-stage renal disease patients. Who received continuous ambulatory peritoneal dialysis treatment at Maharaj Nakhon Si Thammarat Hospital. Data were analyzed by using descriptive study such as frequency, percentage, and T-test.

Results: There are 43 cases of fungal peritonitis. Common presentation found in fungal peritonitis patient is abdominal pain and fever. The major risk factor is 62.7% have recent antibiotic therapy before fugal peritonitis and 55.81% have a history of infected CAPD. Non-albicans Candida is the most common group, 53.5%. And 23.3% of the patients died during fungal peritonitis. The factors that are associated with the increased mortality in patients with fugal peritonitis were previous bacterial peritonitis (p=0.01) and hypoalbuminemia (< 2 g/dL)

(p=0.03)

 Conclusion: Prior antibiotic use was an important risk factor predisposing patients to the development of fungal peritonitis. Early detection of fungal peritonitis would lead to early institution of appropriate therapy and prevention of complications.