Tranexamic Acid Use on Surgical Wound Can Reduce Bleeding After Total Knee Replacement (TKR) Surgery

Abstract

Background: Total Knee Replacement (TKR) is a surgery associated with potential major of blood loss. Especially, the patients with old aged and have multiple chronic conditions. These are the people who have the higher risk of blood loss during with TKR.

Objective: To investigate the effects of Tranexamic acid use on surgical wound after TKR surgery as well as to compare post-operative blood loss of patients who received and did not receive Tranexamic acid during surgical wound after TKR surgery.

 Materials and Methods: The researcher retrospectively studied the cases of 48 patients who were being of a TKR. This study was conducted from January, 2013 to April, 2016.

Results: The patients who received Tranexamic acid use surgical wound after TKR surgery was statistically significant (p-value = 0.001) had post-operative blood loss less than those patients who did not receive. And these patients who received Tranexamic acid had post-operative hemoglobin values more than those patients who did not receive which was statistically significant (p-value = 0.001). Furthermore, the post-operative blood transfusion rate was found that patients who did not received Tranexamic acid was 68.2% but those patients who received Tranexamic acid was 15.4%. In terms of post-operative blood loss volume, patients who received Tranexamic acid use had less lower chance of bleeding after prosthetic knee surgery than those patients who did not receive which was statistically significant (p-value = 0.001). The risks of blood loss was less than 0.59 times (95% CI = 0.37-0.82)

 Conclusions: These results suggest that Tranexamic acid use can reduce blood loss after TKR surgery. This suggestion can be an alternative option to apply using Tranexamic acid for the effective treatment for patients.