Antimicrobial Properties of Thai Herbal Plants for Application in Root Canal Treatment

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Chalermkwan Phuvoravan
Visakha Aupaphong
Orapan Saraban
Praphatsorn Uraisin
Chavisa Sukcharoenkraisri

Abstract

The aim of this article was to collect the data published in the research related to antimicrobial property of herbal plant that can be cropped in Thailand. This preliminary data could be used to develop herbal plant products as an alternative in endodontic therapy. This literature review was conducted using electronic databases such as PubMed, ScienceDirect, Wiley, ResearchGate, Elsevier and Google Scholar. The search was done with the keywords: Herbs, Herbal extract, Endodontics, Root canal, Antibacterial, Antimicrobial, Antifungal. The results showed that Thai herbal plant exhibited the antimicrobial activity against both bacteria and fungi. This article selected 7 types of Thai herbal plants which were Neem, Noni, Turmeric, Triphala, Aloe vera, Garlic and Guava. These herbs shown favorable outcomes in eradication of endodontic microorganisms in both single or mixed culture and biofilm.

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Phuvoravan C, Aupaphong V, Saraban O, Uraisin P, Sukcharoenkraisri C. Antimicrobial Properties of Thai Herbal Plants for Application in Root Canal Treatment. Khon Kaen Dent J [Internet]. 2022 Jul. 11 [cited 2022 Oct. 5];25(2):113-26. Available from: https://he01.tci-thaijo.org/index.php/KDJ/article/view/250666
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References

Almadi EM, Almohaimede AA. Natural products in endodontics. Saudi Med J 2018;39(2):124-30.

Abul N, Karthick K, Mathew S, Deepa NT. Herbal Extracts in Endodontics. J Indian Acad Dent Spec Res 2017;4(1):23-7.

National committee on drug system development. National drug policy B.E. 2554 and strateries for drug system development B.E. 2555-2559. Nontaburi: Publishing house of the agricultural cooperative federation of Thailand;2011.

Meksawaschai C. Evaluation of policies promoting the use of herbal medicine in hospital in the ministry of public health in sraburi provine in 2017. J Thai Trad Alt Med 2019;17(3).516-26.

Mathurasia W, Phoolcharoen W, Sooampon S. Thai herbs: the potential apllication in ajuctive periodontal therapy. J Dent Assoc Thai 2018; 68(1):1-12.

Jain I, Jain P, Bisht D, Sharma A, Srivastava B, Gupta N. Use of traditional indian plants in the inhibition of caries-causing bacteria- streptococcus mutans. Braz Dent J 2015;26(2):110-15.

Radafshar G, Mahboob F, Kazemnejad E. A study to assess the plaque inhibitory action of herbal-based toothpaste: a double-blind controlled clinical trial. J Med Plant Res 2010;4(12):1182-6.

Sushma R, Sathe TT, Farias A, Sanyal PK, Kiran S. Nature cures: an herbal alternative formulation as a denture cleanser. Ann Afr Med 2017;16(1):6-12.

Nimma VL, Talla HV, Bairi JK, Gopaldas M, Bathula H, Vangdoth S. Holistic healing through herbs: effectiveness of aloe vera on post extraction socket healing. J Clin Diagn Res 2017;11(3):ZC83-6

Isola G, Matarese M, Ramaglia L, Iorio-siciliano V, Cordasco G, Matarese G. Efficacy of a drug composed of herbal extracts on postoperative discomfort after surgical removal of impacted mandibular third molar: a randomized, triple-blind, controlled clinical trial. Clin Oral Investig 2019;23(5):2443-53.

Hamedi S, Sadeghpour O, Shamsardekani MR, Amin G, Hajighasemali D, Feyzabadi Z. The most common herbs to cure the most common oral disease: stomatitis recurrent aphthous ulcer (RAU). Iran Red Crescent Med J 2016;18(2):e20694.

Peciuliene V, Maneliene R, Balcikonyte E, Drukteinis S, Rutkunas V. Microorganisms in root canal infection: a review. Stomatologija 2009;10(1):4-9.

Figdor D, Gulabivala K. Survival against the odds: microbiology of root canals associated with post

treatment disease. Endodontic Topics. 2008;18(1):62-77.

Jorgensen JH, Ferraro MJ. Antimicrobial susceptibility testing: a review of general pronciples and contemporary practices. Clin Infect Dis 2009;49(11):1749-55.

Leelapornpisid W, Novak-Frazer L, Qualtrough A, Rautemaa-Richardson R. Effectiveness of D, L-2-hydroxyisocaproic acid (HICA) and alpha-mangostin against endodontopathogenic microorganisms in a multispecies bacterial-fungal biofilm in an ex vivo tooth model. Int Endod J 2021. doi: 10.1111/ iej.13623.

Leelapornpisid W, Poomanee W. Investigation of antimicrobial properties of Mangifera indica L. kernel extract on multispecies Enterococcus faecalis-Candida albicans biofilm in an ex vivo tooth model. CM Dent J 2021; 42(2):65-74.

Singh H, Kaur M, Dhillon JS, Batra M, Khurna J. Neem: A magic herbs in endodontics. Stomatological Dis Sci 2017;1:50-4.

Mustafa M. Antibacterial efficacy of neem (azadirachta indica) extract against enterococcus faecalis: an in vitro study. J Contemp Dent Pract 2016;17(10):791-4.

Hedge V, Kesaria D. Comparative evaluation of antimicrobial activity of neem, propolis, turmeric, liquorice and sodium hypochlorite as root canal irrigants against E. faecalis and C. albicans - an in vitro study. Endodontol 2013;25(2):38-45.

Prasad SD, Goda PC, Reddy KS, Kumar CS, Hemadri M, Reddy D. Evaluation of antimicrobial of neem and aloe vera leaf extracts in comparison with 3% sodium hypochlorite and 2% chlorhexidine against E.Eeacalis and C.albican. J of Dr NTR Health Sci 2016:5(2);104-10.

Bhargava K, Kumar T, Aggarwal S, Zinzarde S, Sanap A, Patil P. Comparative evaluation of the antimicrobial efficacy of neem, green tea, triphala and sodium hypochlorite: An in vitro study. J Dent Res Review 2015;2(1):13-6.

Podar R, Kulkarni GP, Dadu SS, Singh S, Singh SH. In vivo antimicrobial efficacy of 6% morinda citrifolia, azadirachta indica, and 3% sodium hypochlorite as root canal irrigants. Eur J Dent 2015;9(4):529-34.

Tyagi SP, Sinha DJ, Garg P, Singh UP, Mishra CC, Nagpal R. Comparison of antimicrobial efficacy of propolis, morinda citrifolia, azadirachta indica (Neem) and 5% sodium hypochlorite on candida albicans biofilm formed on tooth subtract: An in vitro study. J Conserv Dent 2013;16(6):532-5.

Sharma C, Vas AJ, Goala P, Gheewala TM, Rizvi TA, Hussain A. Ethanolic neem leaf extract prevents growth of MCF-7 and Hela cells and potentiates the therapeutic index of cisplatin. J Oncol 2014; 2014:1-10.

Someya T, Sano K, Hara K, Sagana Y, Watanabe T, Wijesekara RGS. Fibroblast and keratocyte gene expression following exposure to extracts of neem plant (Azadirachta indica). Data Brief 2017;16:982-92.

Abou Assi R, Darwis Y, Abdulbaqi IM, Khan AA, Vuanghao L, Laghari MH. Morinda citrifolia (noni): a comprehensive review on its industrial uses, pharmacological activities, and clinical trials. Arabian J Chem 2017:10(5);691-707.

Wang MY, West BJ, Jensen CJ, Nowicki D, Su C, Palu AK, et al. Morinda citrifolia (noni): a literature review and recent advances in noni research. Acta Pharmacol Sin 2002;23:1127–41.

Chandwani M, Mittal R, Chandak S, Pimpale J. Effectiveness of morinda citrifolia juice as an intracanal irrigant in deciduous molars: an in vivo study. Dent Res J (Isfahan) 2017;14(4):246-51.

Chaitanya BV, Somisetty KV, Diwan A, Pasha S, Shetty N, Reddy Y, et al. Comparison of antibacterial efficacy of turmeric extract, morinda citrifolia and 3% sodium hypochlorite on enterococcus faecalis: an in-vitro study. J Clin Diagn Res 2016;10(10):ZC55-7.

Kandaswamy D, Venkateshbabu N., Gogulnath D, Kindo AJ. Dentinal tubule disinfection with 2% chlorhexidine gel, propolis, morinda citrifolia juice, 2% povidone iodine, and calcium hydroxide. Int Endod J 2010;43(5):419–23.

Murrey P, Farber RM, Namerow KN, Kuttler S, Garcia-Godoy F. Evaluation of morinda citrifolia as endodontic irrigant. J Endod 2008;34(1):66-70.

Saghiri MA, García-Godoy F, Asgar K, Lotfi M. The effect of morinda citrifolia juice as an endodontic irrigant on smear layer and microhardness of root canal dentin. Oral Sci Int 2013;10(2):53–7.

https://ittm.dtam.moph.go.th [Homepage on the Internet]. The Institute of Thai Traditional Medicine. Ministry of Public Health. Available from: http://164.115.41.179/tm/sites/default/files /ยาสมุนไพรในบัญชียาหลักแห่งชาติ.pdf.

Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee R. Turmeric and curcumin: biological action and medicinal application. Curr Sci 2004;87(1):44-53.

Kumar H. An in vitro evaluation of the antimicrobial efficacy of curcumin longa, tachyspermum ammi, chlorhexidine gluconate, and calcium hydroxide on enterococcus faecalis. J COnserv Dent 2013;16:144-7

Sinha D, Vasudeva A, Jaiswal N, Garg P, Tyagi S, Singh J. Antibacterial efficacy of melaleuca alternifolia (tea tree oil), curcuma longa (turmeric), chlorhexidine, and 5% sodium hypochlorite against enterococcus faecalis: an in vitro study. Saudi Endod J 2015;5(3):182-6.

Hedge M, Shetty S, Yelapure M, Patil A. Evaluation of antimicrobial activity of aqueous and hydro-alcoholic curcuma longa extracts against endodontic pathogen. J Pharm 2012;2(2);192-8.

Neelakantan P, Subbarao C, Subbarao CV. Analysis of antimicrobial activity of curcumin against enterococcus faecalis. Int J Curr Res 2017;3:37-41.

Digole VR, Dua P, Shergill S, Pathak P, Kumar V, Prakash P. Comparative evaluation of antimicrobial efficacy of calcium hydroxide, curcumin and aloe vera as an intracanal medicament: An in vivo study. IP Indian J Conserv Endod 2020;5(3):114-9.

Peterson C, Denniston K, Chopra D. Therapeutic Uses of triphala in ayurvedic medicine. J Altern Complement Med 2017;23(8):607–614.

Shakouie S, Eskandarinezhad M, Gasemi N, Milani AS, Samiei M, Golizadeh S. An in vitro comparison of the antibacterial efficacy of triphala with different concentrations of sodium hypochlorite. Iran Endod J 2014;9(4):287-9.

Garg P, Tyagi S, Sinha D, Singh U, Malik V, Maccune E. Comparison of antimicrobial efficacy of propolis, morinda citrifolia, azadirachta indica, triphala, green tea polyphenols and 5.25% sodium hypochlorite against Enterococcus fecalis biofilm. Saudi Endod J 2014;4(3):122-7.

Thomas S, Asokan S, John B, Priya G, Kumar S. Comparison of microbial efficacy of diode laser, triphala, and sodium hypochlorite in primary root canals: a randomized controlled trial. Int J Clin Ped Dent 2017;10(1):14-7.

Satti P, Kakarla P, Jogendra Avula SS, Muppa R, Kiran Rompicharla SV, Biswas S. Indigenous irrigants as potent antimicrobials in endodontic treatment: An in vitro study. J Indian Soc Pedod Prev Dent 2019;37(3):275-81.

Raj R, Varma B, Sureshkumar J, Kumaran P, Xavier AM, Madhavan M. Comparison of cytotoxicity and smear layer removal efficacy of triphala (an Indian ayurvedic herbal formulation) and 5.25% sodium hypochlorite as root canal irrigants: An in vitro study. J Indian Soc Pedod Prev Dent 2020;38(4):343-9.

Sowjanyaa J, Thomas T, Chandana CS. Comparative evaluation of the efficacy of smear layer removal by ethylenediaminetetraacetic acid, triphala, and german chamomile as irrigants- a scanning electron microscopy study. J Advanc Pharm Edu Res 2017;7(3):267-71.

Choudhary E, Indushekar KR, Saraf BG, Sheoran N, Sardana D, Shakhar A. Exploring the role of morinda citrifolia and triphala juice in root canal irrigation: an ex vitro study. J Conserv Dent. 2018;21(4):443–9.

Tangjitjareonkun J, Supabphol R. Application of aloe vera on wound healing. J Med Health Sci 2015;22(3):53-67.

Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules 2020;25(6):1324.

Surjushe A, Vasani R, Saple DG. Aloe vera: a short review. Indian J Dermatol 2008;53(4):163-6.

Athiban P, Borthakur B, Ganesan S, Swathika B. Evaluation of antimicrobial efficacy of Aloe vera and its effectiveness in decontaminating gutta percha cones. J Conserv Dent 2012;15(3):246–8.

Kurian B, Swapna DV, Nadig R, Ranjini MA, Rasmi MA, Bolar SR. Efficacy of calcium hydroxide, mushroom, and Aloe vera as an intracanal medicament against Enterococcus faecalis: an in vitro study. Endodont 2016;28(2):137-42.

Jose J, Krishnamma S, Peedikayil F, Aman S, Tomy N, Mariodan JP. Comparative evaluation of antimicrobial activity of QMiX, 2.5% sodium hypochlorite, 2% chlorhexidine, guava leaf extract and aloe vera extract against enterococcus faecalis and candida albicans-an in vitro study. J Clin Diag Res 2016,10(5);20-24.

Babaji P, Jagtap K, Lau H, Bansal N, Thajuraj S. Sondhi P. Comparative evaluation of antimicrobial effect of herbal root canal irrigants (morinda citrifolia, azadirachta indica, aloe vera) with sodium hypochlorite: An in vitro study. Int Soc Prev Community Dent 2016;6(3):196–9.

Ehsani M, Marashi MA, Zabihi E, Issazadeh M, Khafri S. Comparison between antibacterial activity of propolis and aloe vera on enterococcus faecalis (an in vitro study). Int J Mol Cell Med 2013;2(3):110–6.

Newall CA, Anderson LA, Phillipson JD. London: Pharmaceutical Press; 1996. Herbal medicines: A guide for health-care professionals; p. 296.

Block E. The chemistry of garlic and onions. Sci Am 1985;252(3):114–9.

Octavia A, Budiardjo SB, Indiarti IS, Fauziah E, Suharsini M, Sutadi H, et al. Garlic extract efficacy against the viability of enterococcus faecalis (in vitro). Int J Applied Pharm 2019;11:194-7.

Karkare SR, Ahire NP, Khedkar SU. Comparative evaluation of antimicrobial activity of hydroalcoholic extract of aloe vera, garlic, and 5% sodium hypochlorite as root canal irrigants against enterococcus faecalis: an in vitro study. J Indian Soc Pedod Prev Dent 2015;33(4):274-8.

Pandey S, Shekhar R, Paul R, Hans M, Garg A. a comparative evaluation and effectiveness of different antimicrobial herbal extracts as endodontic irrigants against enterococcus faecalis and candida albicans- an in vitro study. U Dent Sci 2018;4(2):1-7.

Roy M, Bhaumik T, Das U, Mitra A. Comparative evaluation of effectiveness of garlic extract with conventional intracanal irrigants on candida albicans- an in vitro study. Imperial J Interdisciplinary Research 2017;3:219-22.

Abu Zeid ST, Eissa SA. Comparative study on antibacterial activities of two natural plants versus three different intracanal medications. 2008. Available from : https://www.kau.edu.sa/ Files/165/Researches/19240_Comparative%20Study%20On.pdf.

Eswar K, Venkateshbabu N, Rajeswari K, Kandaswamy D. Dentinal tubule disinfection with 2% chlorhexidine, garlic extract, and calcium hydroxide against Enterococcus faecalis by using real-time polymerase chain reaction: In vitro study. J Conserv Dent 2013;16(3):194-8.

Pooraninagalakshmi J, Prasanna Latha Nadig, Arul Selvan, Jaylakshmi KB, Manje Gowda. Efficacy of garlic extract as surfactant along with root canal sealer- an in vitro study. Int J Sci Res 2018;9(1): 528-32.

Yazdani D, Tan YH, Abidin M, Jaganath IB. A review on bioactive compounds isolated from plants against plant pathogenic fungi. J Med Plant Res 2011:5(30);6584-9.

Noushad MC, Balan B, Basheer S, Usman SB, Askar M. Antimicrobial efficacy of different natural extracts against persistent root canal pathogens: an in vitro study. Contemp Clin Dent 2018;9:177-81

Syam S, Arifin N, Irkan N. Difference in effectiveness of guava leaf extract and lime water as irrigation material of root canal as inhibitors of baterial enterococcus faecalis. J Dentomaxillofac Sci 2018;3(3):156-61.

Venugopal V, Prakasan G, Sandeep PM, Sunil A, Makunda A, Samuel S. Efficacy of psidium guava leaf extract on streptococcus mutans and enterococcus faecalis-an in vitro study. J Med Sci Clin Res 2019;7(5):752-8.

Dubey S. Comparative antimicrobial efficacy of herbal alternatives (emblica officinalis, psidium guajava), MTAD, and 2.5% sodium hypochlorite against enterococcus faecalis: an in vitro study. J Oral Biol Craniofac Res 2016;6(1):45-8.