Augmenting Fluoxetine with Praying Therapy for Patients with Major Depressive Disorder
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Abstract
ABSTRACT
Objective : To assess the efficacy of augmentating fluoxetine with praying therapy compared to fluoxetine monotherapy for patients diagnosed with major depressive disorder (MDD).
Methods : A single-blind randomized controlled trial study was conducted at Buddhasothorn hospital. Patients with major depressive disorder based on the DSM-IV criteria were purposively selected and randomly allocated into two groups. The treatment group was
treated with fluoxetine 20 mg/day augmented with praying, while the control group was treated with fluoxetine 20 mg/day only. Measurement as the following: 1) Hamilton rating scale for depression, thai version (HAM-D 17-item), 2) praying book and either tape cassette or CD recording of the prayers to use while praying along with a praying compliance evaluation form. The data of the drop-out group was managed with the last observation carried forward (LOCF) technique. Analysis was performed using t-test and statistical significance was set at 5% (p = 0.05)
Results : Fifty-nine patients were enrolled in the study; 27 were assigned to the treatment group and 32 as the control group. The number of patients in treatment group was 8 and the control group was 15 at the end of the study. No significant differences between 2 group HAM-D in mean score difference of the HAM-D. The mean scores within group during week 0, 1, 2, and 4 were reduced statistically in both groups.
Conclusion : Praying augmented therapy with fluoxetine is not superior effective than fluoxetine only for patients with major depressive disorder.
Objective : To assess the efficacy of augmentating fluoxetine with praying therapy compared to fluoxetine monotherapy for patients diagnosed with major depressive disorder (MDD).
Methods : A single-blind randomized controlled trial study was conducted at Buddhasothorn hospital. Patients with major depressive disorder based on the DSM-IV criteria were purposively selected and randomly allocated into two groups. The treatment group was
treated with fluoxetine 20 mg/day augmented with praying, while the control group was treated with fluoxetine 20 mg/day only. Measurement as the following: 1) Hamilton rating scale for depression, thai version (HAM-D 17-item), 2) praying book and either tape cassette or CD recording of the prayers to use while praying along with a praying compliance evaluation form. The data of the drop-out group was managed with the last observation carried forward (LOCF) technique. Analysis was performed using t-test and statistical significance was set at 5% (p = 0.05)
Results : Fifty-nine patients were enrolled in the study; 27 were assigned to the treatment group and 32 as the control group. The number of patients in treatment group was 8 and the control group was 15 at the end of the study. No significant differences between 2 group HAM-D in mean score difference of the HAM-D. The mean scores within group during week 0, 1, 2, and 4 were reduced statistically in both groups.
Conclusion : Praying augmented therapy with fluoxetine is not superior effective than fluoxetine only for patients with major depressive disorder.
Article Details
How to Cite
Pratoomsri, W. (2013). Augmenting Fluoxetine with Praying Therapy for Patients with Major Depressive Disorder. Journal of the Psychiatric Association of Thailand, 58(1), 67–74. Retrieved from https://he01.tci-thaijo.org/index.php/JPAT/article/view/8246
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Original Articles
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