Antipsychotic Drug Prescription Pattern for Patients with Schizophrenia who Admited at Srinagarind Hospital
Objectives : to study the of antipsychotic prescription patterns for patients with schizophrenia who admitted at Srinagarind hospital and to analyze factors associated with high dose prescription and polypharmacy therapy.
Methods : A prospective descriptive study was conducted. Subjects were all patients with schizophreniav who had been admitted to psychiatric ward during 1 April 2010 to 31 March 2011 at Srinagarind Hospital. Demographic data, psychiatric history, doses and types of antipsychotic drug prescription were collected. Data analysis used descriptive statistic such as percentage, mean, standard deviation, Odds ratios, 95% CI, with chi square test.
Results: Total 49 patients were recruited; majority was male (63.3%) and mean aged of 38.7 years old. Mean duration of illness was 11.6 years. Mean number of hospitalization was 3.5. The most frequent psychiatric symptoms were delusions (75.5%). Mean length of stay in the hospital was 16 days. Conventional antipsychotics were prescribed as much as second generation antipsychotics as 38.8%. Haloperidol (25.0%) was the most frequently prescribed first-generation drug, and clozapine (28.6%) was the most prescribed second-generation drugs. Sixty-one percent of them received a single antipsychotic drug, while 39% of them took two or more antipsychotics (polypharmacy). Among the 30 patients receiving a single antipsychotic drug, 60% had second generation antipsychotics, while 19 patients who took polypharmacy, and 57.9% took combinations of conventional and second-generation drugs. The mean daily dose of antipsychotics for all was 750.10 ± 503.01 mg of chlorpromazine dose equivalent (CPZeq). Twenty five percent of patients received high-dose (CPZeq >1000 mg/d). Factors associated with high-dose antipsychotic prescription was being current smoker (OR=5.17, 95%CI=1.24-21.59,p=0.03), duration of illness less than 10 years (OR=10.42.95%CI=10.42-89.13, p=0.01) and aggression (OR =4.73, 95%CI=1.18-19.02,p=0.03). No significant factors associated with polypharmacy prescription.
Conclusion: Daily dose of antipsychotic prescription in Thai patients with schizophrenia was moderate dose. High-dose prescription was found only 24.5% while polypharmacy 38.8%. High-dose prescription associated with current smoking, less chronicity, and aggression.
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Sanguanvichaikul, T., Arunpongpaisal, S., & Paholpak, P. (2013). Antipsychotic Drug Prescription Pattern for Patients with Schizophrenia who Admited at Srinagarind Hospital. Journal of the Psychiatric Association of Thailand, 58(1), 41-56. Retrieved from https://he01.tci-thaijo.org/index.php/JPAT/article/view/8241
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