Metabolic syndrome in antipsychotic treated psychiatric patients.

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Sorayut Vasiknanonte
Sermsak Oukantawong

Abstract

Abstract
Background: Psychiatric patients treated with antipsychotics have an increased risk of metabolic syndrome, that leads to cardiovascular disease and type 2 diabetes, and they have higher mortality
rate, compared with the general popuration.
Objecttives: 1. To find the prevalence rate of metabolic syndrome in psychiatric patients who treated with first or second generation antipsychotics. 2. To compare the metabolic components,
such as waist circumference, blood pressure, serum level of fasting triglyceride, high density lipoprotein, and fasting glucose between first and second generation antipsychotics treated patients. 3. To find the risk factors of metabolic syndrome in these patients.
Methods: Cross-sectional survey of psychiatric patients who are at least 15 years old and have been treated with a first or second generation antipsychotics for at least 3 months. Patients
demographic data, waist circumference, blood pressure, serum level of fasting triglyceride, high density lipoprotein, fasting glucose, diagnosis, and medications were recorded.
Results: 134 patients were recruited, which most of them were diagnosed as schizophrenia or mood disorders. The prevalence of metabolic syndrome according to Updated ATP III criteria was
30.6%. Female patients had more risk than male significantly (OR = 2.35, 95%CI = 1.05-5.23). There was no significant difference in prevalence of metabolic syndrome between first and second
generation antipsychotics used patients, but the second generation antipsychotic treated patients had significantly higher mean fasting glucose (100.1 mg/dl vs. 95.9 mg/dl, p=0.029).
Conclusions: The risk of metabolic syndrome was not different among first and second generation antipsychotics treated patients. However, all antipsychotics treated patients were high
risk of metabolic syndrome, so they should be checked for metabolic parameters as baseline before treatment and follow up assessment should be done regularly.

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How to Cite
Vasiknanonte, S., & Oukantawong, S. (2013). Metabolic syndrome in antipsychotic treated psychiatric patients. Journal of the Psychiatric Association of Thailand, 54(3), 273–286. Retrieved from https://he01.tci-thaijo.org/index.php/JPAT/article/view/7668
Section
Original Articles
Author Biographies

Sorayut Vasiknanonte, Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Hat Yai

Sermsak Oukantawong, Division of Psychiatry, Suratthani Hospital, Suratthani 84000, Thailand