Quality of Life and Associated Factors in Patients with Major Depressive Disorder: A Cross-Sectional Study at Khon Kaen Hospital
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Abstract
Objective: To study the quality of life among patients with Major Depressive Disorder (MDD) and the association between demographic data, severity of depression, and quality of life.
Methods: A cross-sectional study was conducted in patients with MDD diagnosed based on the DSM-5 or ICD-10 criteria who attended the outpatient clinic at the Department of Psychiatry, Khon Kaen Hospital, between November 2023 and January 2024. Participants were assessed using a demographic data form, the PHQ-9 (Patient Health Questionnaire-9), and the WHOQOL-BREF-THAI (World Health Organization Quality of Life Brief - Thai). Data were analyzed using multivariable linear regression analysis.
Results: There were 100 patients in this study, mostly female (75.0%), with a mean age of 33.6 years. Forty-five participants (45%) had moderate to severe depression, and most (75 patients, 75.0%) had a moderate quality of life. Marital status, religion, financial status, underlying medical conditions, substance use, family history of psychiatric illness, and severity of depression were significantly associated with quality of life (p < 0.05).
Conclusion: Marital status, religion, and financial status were significantly associated with quality of life. Additionally, underlying medical conditions, substance use, and family history of psychiatric illness also played a significant role (p < 0.05). The severity of depression had a strong negative impact on quality of life. Furthermore, higher depression scores on the PHQ-9 were associated with lower quality of life in patients with depression.
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