A Retrospective Cohort Study of the Prevalence of Attempted Suicide by Pesticide Poisoning and Related Factors among Patients Presenting to Chiangrai Prachanukroh Hospital during 2012 - 2021
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Abstract
Objective: To investigate the prevalence of pesticide use in suicide attempts and the factors associated with pesticide use, including gender, age, types of commonly used pesticides, mortality rates, gender and age groups of those who died, the risk of death from different types of pesticides, complications from pesticide use, and the duration from hospital admission to death among patients attempting suicide treated at Chiangrai Prachanukroh Hospital from 2012 to 2021.
Methods: This research is a retrospective cohort study of patients who attempted suicide and attended the emergency room of Chiangrai Prachanukroh Hospital. Data were collected from medical records and hospital databases using ICD-10 codes related to self-harm (X60-X84), including death certificates from the Registrar's Office.
Results: A total of 2,639 patients who attempted suicide were treated in 2,800 hospital visits. Of these, 987 visits (35.2%) involved suicide attempts using pesticides. The average age was 39.1±16.9 years, with a male-to-female ratio of 2.1:1. The most commonly used pesticide was paraquat (65.7%), followed by glyphosate (6.7%) and organophosphates (5.0%). Patients who used paraquat had the highest mortality rate (53.5%), with most deaths occurring within the first four days and 39.7% of deaths occurring after hospital discharge. The main complications were acute respiratory failure, acute liver failure, and acute renal failure. The ban on paraquat in 2020 resulted in a significant decrease in deaths from this pesticide, from 34 in 2020 to 13 in 2021.
Conclusion: The use of pesticides for suicide attempts is prevalent in agricultural communities, particularly with paraquat, which has a high mortality rate. Banning the use of paraquat may be a crucial measure in reducing suicide-related deaths in the agricultural areas of Chiang Rai province.
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References
World Health Organization. WHO mortality database [EB/OL] [Internet]. [cited 2024 May 13]. Available from: https://www.who.int/news-room/fact-sheets/detail/suicide.
Mew EJ, Padmanathan P, Konradsen F, Eddleston M, Chang SS, Phillips MR, et al. The global burden of fatal self-poisoning with pesticides 2006-15: systematic review. J Affect Disord 2017;219:93–104.
Gunnell D, Eddleston M. Suicide by intentional ingestion of pesticides: a continuing tragedy in developing countries. Int J Epidemiol 2003;32:902–9.
Bonvoisin T, Utyasheva L, Knipe D, Gunnell D, Eddleston M. Suicide by pesticide poisoning in India: a review of pesticide regulations and their impact on suicide trends. BMC Public Health 2020;20:251.
World Health Organization. Preventing suicide: A resource for pesticide registrars and regulators [Internet]. Geneva: World Health Organization and Food and Agriculture Organization of the United Nations; 2019. Available from: https://www.who.int/publications/i/item/9789241516389.
Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, Remião F, Bastos ML, Carvalho F. Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol 2008;38:13–71.
Laohaudomchok W, Nankongnab N, Siriruttanapruk S, Klaimala P, Lianchamroon W, Ousap P, et al. Pesticide use in Thailand: Current situation, health risks, and gaps in research and policy. Hum Ecol Risk Assess Int J 2021;27:1147–69.
Chiang Rai Provincial Agriculture and Cooperative Office. Basic information about Chiang Rai Province: used to support government inspections and traveling cabinet for the month of April 2024 [Internet]. [cited 2024 May 9]. Available from: https://www.opsmoac.go.th/chiangrai-dwl-files-442991791952.
National Center for Suicide Prevention. Report on the suicide situation in Thailand, fiscal year 2023 [Internet]. [cited 2024 May 9]. Available from: https://suicide.dmh.go.th/books/view.asp?id=27.
Chaiprakarn W, Kanjanakaroon R, Pongkaew W, Lotrakul M. Characteristics of attempted suicide patients presenting to Chiang Rai Prachanukroh hospital during 2012-2016. Chiang Mai Medical Journal 2019;1:57–67.
Eddleston M, Buckley NA, Eyer P, Dawson AH. Management of acute organophosphorus pesticide poisoning. Lancet 2008;371:597–607.
Wedamulla A, Pongpanich S. Incidence of suicide attempts and its associated factors at the provincial general hospital Badulla, Sri Lanka. J Health Res 2010, 24(supp/2): 77-81.
Pratipatpong T. A study of 270 suicidal attempt patients in Nakhonpathom Hospital. Reg 9-7 Med J 2008;27:259–66.
Luealai P, Yeabkai Y. Suicide Behavior among People in Srinakhon District, Sukhothai Province. Journal of Disease Prevention and Control: DPC, 2 Phitsanulok 2020;7:54–81.
Suteeprasert T, Tangtekakul S, Bunsiriluck S, Sricharern P, Thongnak T. The rate of suicide and factors associated with suicidal behaviors: a case study of Suphanburi Province. Srinakharinwirot Res Dev J Humanit Soc Sci 2024;16:1–12.
Suphan M. The phenomenon of attempt to commit suicide in Sriprachan District : A case study of the people who attempted suicide in Sriprachan district, Suphanburi province. J Environ Community Health 2020;5:106–13.
Masan H, Lotrakul M, Sudawan J. Characteristics of patients with paracetamol overdose and principal risk factor for severe hepatotoxicity. J Psychiatr Assoc Thai 2019;64:127–38.
Narongchai P, Narongchai S. Paracetamol overdose in suicidal attempt patients. J Med Assoc Thai 2004;87:423–6.
Suppapitiporn S, Suppapitiporn S. Attempted suicide by acetaminophen ingestion. Chulalongkorn Med J 2003;47:713–25.
Tu CY, Yen TH, Chang CM, Chen HY, Yen YC, Guo MC, et al. Characteristics and psychopathology of 1,086 patients who self-poisoned using pesticides in Taiwan (2012–2019): A comparison across pesticide groups. J Affect Disord 2022;300:17–26.
Ajdacic-Gross V, Weiss MG, Ring M, Hepp U, Bopp M, Gutzwiller F, et al. Methods of suicide: international suicide patterns derived from the WHO mortality database. Bull World Health Organ 2008;86:726–32.
Buckley NA, Fahim M, Raubenheimer J, Gawarammana IB, Eddleston M, Roberts MS, et al. Case fatality of agricultural pesticides after self-poisoning in Sri Lanka: a prospective cohort study. Lancet Glob Health 2021;9:e854–62.
Van Der Hoek W, Konradsen F. Risk factors for acute pesticide poisoning in Sri Lanka. Trop Med Int Health 2005;10:589–96.
Lee JW, Hwang IW, Kim JW, Moon HJ, Kim KH, Park S, et al. Common pesticides used in suicide attempts following the 2012 paraquat ban in Korea. J Korean Med Sci 2015;30:1517–21.
Chang ShuSen CS, Lu TsungHsueh LT, Eddleston M, Konradsen F, Sterne JAC, Lin JinJia LJ, et al. Factors associated with the decline in suicide by pesticide poisoning in Taiwan: a time trend analysis, 1987-2010. Clin Toxicol Phila 2012;50:471–80.
Agrawaal KK, Karki P. Clinico-epidemiological study on pesticide poisoning in a tertiary care hospital in eastern Nepal. J Nepal Med Assoc 2014;52:972–6.
Eddleston M. Patterns and problems of deliberate self-poisoning in the developing world. QJM 2000;93:715–31.
Gawarammana IB, Buckley NA. Medical management of paraquat ingestion. Br J Clin Pharmacol 2011;72:745–57.
Liu HL, Chen WL, Yang MC, Lin HM, Chou CC, Chang CF, et al. Prediction of early mortality in patients with paraquat intoxication. J Acute Med 2013;3:6–10.
Tajai P, Kornjirakasemsan A. Predicting mortality in paraquat poisoning through clinical findings, with a focus on pulmonary and cardiovascular system disorders. J Pharm Policy Pract 2023;16:123.
Kim S ji, Gil HW, Yang JO, Lee EY, Hong SY. The clinical features of acute kidney injury in patients with acute paraquat intoxication. Nephrol Dial Transplant 2009;24:1226–32.
Tsao TCY, Juang YC, Lan RS, Shieh WB, Lee CH. Respiratory failure of acute organophosphate and carbamate poisoning. Chest 1990;98:631–6.
Delirrad M, Majidi M, Boushehri B. Clinical features and prognosis of paraquat poisoning: a review of 41 cases. Int J Clin Exp Med 2015;8:8122.
Thai farmers are at risk of becoming sick from pesticide-pesticide poisoning. In 2018, nearly 10,000 people were found to be sick. [Internet]. Hfocus.org. [cited 2024 Jul 30]. Available from: http://www.hfocus.org/content/2019/06/17297
Chang SS, Lin CY, Lee MB, Shen LJ, Gunnell D, Eddleston M. The early impact of paraquat ban on suicide in Taiwan. Clin Toxicol 2022;60:131–5.
Cha ES, Chang SS, Gunnell D, Eddleston M, Khang YH, Lee WJ. Impact of paraquat regulation on suicide in South Korea. Int J Epidemiol 2016;45:470–9.
Myung W, Lee GH, Won HH, Fava M, Mischoulon D, Nyer M, et al. Paraquat prohibition and change in the suicide rate and methods in South Korea. PloS One 2015;10:e0128980.
Weerasinghe M, Pearson M, Konradsen F, Agampodi S, Sumith JA, Jayamanne S, et al. Emerging pesticides responsible for suicide in rural Sri Lanka following the 2008–2014 pesticide bans. BMC Public Health 2020;20:780.
Indira M, Chowallur MJ, Aryamol MK, Lin CY, Chang SS, Sooraj M, et al. Effect of pesticide ban on suicide trend – a 20-year study from a tertiary care center in Central Kerala from 2001 to 2020. Clin Toxicol (Phila) 2022;60:1214–9.
Nakhokwik Y, Popradit A, Pakvilai N, Wiangnon J, Wanasiri A. The model of suitable agricultural after stopping paraquat and glyphosate used in special management zone at Phu Kao - Phu Phan Kham National Park. J Leg Entity Manag Local Innov 2021;7:33–47.
Roberts DM, Karunarathna A, Buckley NA, Manuweera G, Sheriff MR, Eddleston M. Influence of pesticide regulation on acute poisoning deaths in Sri Lanka. Bull World Health Organ 2003;81:789–98.
Sabzghabaee AM, Eizadi-Mood N, Montazeri K, Yaraghi A, Golabi M. Fatality in paraquat poisoning. Singap Med J 2010;51:496–500.
Zalsman G, Hawton K, Wasserman D, van Heeringen K, Arensman E, Sarchiapone M, et al. Suicide prevention strategies revisited: 10-year systematic review. Lancet Psychiatry 2016;3:646–59.