Prevalence of hyperhomocysteinemia in Alzheimer’s disease and vascular dementia at outpatient unit in Ramathibodi hospital: Retrospective study

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Manochar Mongkalig
Papan Thaipisuttikul


Objective: To study the prevalence and associated factors of hyperhomocysteinemia in Alzheimer’s disease and vascular dementia at outpatient unit at Ramathibodi hospital.

Method: This retrospective cross-sectional research was conducted with patients 65 years of age and older who were diagnosed with Alzheimer's disease or vascular dementia. Data which are based on electronic medical records from neurological department and psychiatric department at Ramathibodi hospital from 2015 to 2021, were collected including demographic data and serum homocysteine. Data were analyzed in terms of descriptive statistics, Chi-square test and independent t-test.

Results: This study included 67 Alzheimer's disease patients and 35 vascular dementia. The prevalence of hyperhomocysteinemia in patients with Alzheimer’s disease was 10.45%. The prevalence in patients with vascular dementia was 20.00%. Hyperhomocysteinemia was not statistically associated with age, gender, diabetes mellitus, hypertension, hyperlipidemia, history of smoking and alcohol consumption, plasma folate and vitamin B12 levels in our study.

Conclusion: The prevalence of hyperhomocysteinemia in patients with vascular dementia was higher than Alzheimer’s disease. Although this study found no statistically significant association between vascular risk factors and hyperhomocysteinemia, the effect of hyperhomocysteinemia and its treatment on cognitive function may be better understood by large longitudinal research.

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How to Cite
Mongkalig, M., & Thaipisuttikul, P. (2023). Prevalence of hyperhomocysteinemia in Alzheimer’s disease and vascular dementia at outpatient unit in Ramathibodi hospital: Retrospective study. Journal of the Psychiatric Association of Thailand, 68(1). Retrieved from
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