The Association between Gestational Diabetes Mellitus (GDM) in Mothers and Attention Deficit/Hyperactivity Disorder (ADHD) in Their Offspring
Objective : To examines the association between gestational diabetes mellitus (GDM)
in Thai mothers and attention deficit/hyperactivity disorder (ADHD) in their offspring.
Method : The case-control study was conducted. We enrolled 132 mother-child pairs,
consisting of 66 mothers with ADHD in their offspring (ADHD group) and 66 mothers
without ADHD in their offspring (non ADHD group). Demographic data and obstetric
and neonatal history affecting ADHD in offspring were obtained from mothers and corresponding
children seeking treatment from the Child and Adolescent Psychiatric Unit
and General Child Disease Unit of Maharaj Nakorn Chiang Mai Hospital. Maternal GDM
history was obtained by an interview. The ADHD in the offspring was diagnosed by
certified Thai child and adolescent psychiatrists.
Results : We found the ratio of male vs. female children in the ADHD and the non ADHD
group to be 2.882:1 and 2:1 respectively (P = 0.446). Demographic and obstetric
characteristics were not significantly different between the groups. Maternal GDM was
found in seven mothers in the ADHD group (10.61%) and two mothers in the non ADHD
group (3.03%). In comparison with mothers without GDM, mothers with GDM had an
increased risk of having offspring with ADHD, but without statistical significance
(OR = 3.797, 95% CI = 0.752-19.009, P = 0.105).
Conclusion : GDM is not the factor that increased the risk of ADHD diagnosis in children.
However, it performs the trend of association that GDM might increase the risk of ADHD.
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