Fluid Assessment by Venous Excess Ultrasound
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Abstract
Critically ill patients often experience fluid overload, which is associated with an increased risk of complications and mortality. One key pathophysiological aspect of fluid overload is fluid accumulation in the venous system and/or impaired cardiac function, affecting both systolic and diastolic phases (systolic and diastolic dysfunction). This results in reduced perfusion to vital organs, making the rapid and timely diagnosis and treatment of fluid overload crucial for\ minimizing complications and reducing patient mortality. Traditional physical examination methods may be prone to errors. Currently, a panel of ultrasound techniques known as ‘Point of Care Ultrasound’ (POCUS) refers to the use of ultrasound for specific purposes to guide treatment decisions. POCUS can be performed on multiple organs, a practice referred to as multi-organ POCUS, which includes the assessment of the heart, lungs, and veins. Venous Excess Ultrasound (VExUS), a component of POCUS, is a novel Doppler technique used to assess fluid overload in the venous system. However, VExUS should not be used to predict responsiveness to fluid management. This examination primarily focuses on the inferior vena cava, followed by the hepatic, portal, and renal veins.
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References
Koratala A, Romero-González G, Soliman-Aboumarie H, Kazory A. Unlocking the Potential of VExUS in Assessing Venous Congestion: The Art of Doing It Right. Cardiorenal Med. 2024;14(1):350-74. doi: 10.1159/000539469.
O’Connor ME, Prowle JR. Fluid overload. Crit Care Clin. 2015;31(4):803-21. doi: 10.1016/j.ccc.2015.06.013.
Malbrain ML, Van Regenmortel N, Saugel B, De Tavernier B, Van Gaal P-J, Joannes-Boyau O, et al. Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy. Ann Intensive Care. 2018;8(1):66. doi: 10.1186/s13613-018-0402-x.
Beaubien-Souligny W, Rola P, Haycock K, Bouchard J, Lamarche Y, Spiegel R, et al. Quantifying systemic congestion with Point-Of-Care ultrasound: development of the venous excess ultrasound grading system. Ultrasound J. 2020;12(1):16. doi: 10.1186/s13089-020-00163-w.
Argaiz ER. VExUS Nexus: bedside assessment of venous congestion. Adv Chronic Kidney Dis. 2021;28(3):252-61. doi:10.1053/j.ackd.2021.03.004.
Gupta S, Tomar DS. VEXUS—The Third Eye for the Intensivist?. Indian J Crit Care Med. 2020;24(9):746-7.
Koratala A, Reisinger N. Venous excess Doppler ultrasound for the nephrologist: pearls and pitfalls. Kidney Med. 2022;4(7):100482. doi: 10.1016/j.xkme.2022.100482.
Kenny J-ÉS, Prager R, Rola P, Haycock K, Gibbs SO, Johnston DH, et al. Simultaneous venous-arterial Doppler ultrasound during early fluid resuscitation to characterize a novel Doppler starling curve: a prospective observational pilot study. J Intensive Care Med. 2024;39(7):628-35. doi:10.1177/08850666231224396.
Muñoz F, Born P, Bruna M, Ulloa R, González C, Philp V, et al. Coexistence of a fluid responsive state and venous congestion signals in critically ill patients: a multicenter observational proof-of-concept study. Crit Care. 2024;28(1):52. doi: 10.1186/s13054-024-04834-1.
Beaubien-Souligny W, Galarza L, Buchannan B, Lau VI, Adhikari NK, Deschamps J, et al. Prospective study of ultrasound markers of organ congestion in critically ill patients with acute kidney injury. Kidney Int Rep. 2023;9(3):694-702. doi: 10.1016/j.ekir.2023.12.018.
Islas-Rodríguez J, Miranda-Aquino T, Romero-González G, Rio H-D, Camacho-Guerrero JR, Covarrubias-Villa S, et al. Effect on Kidney Function Recovery Guiding Decongestion with VExUS in Patients with Cardiorenal Syndrome 1: A Randomized Control Trial. Cardiorenal Med. 2024;14(1):1-11. doi: 10.1159/000535641.
McCallum W, Tighiouart H, Testani JM, Griffin M, Konstam MA, Udelson JE, et al. Rates of in-hospital decongestion and association with mortality and cardiovascular outcomes among patients admitted for acute heart failure. Am J Med. 2022;135(9):e337-e52. doi:10.1016/j.amjmed.2022.04.003.
Dias NH, Gomes DR, de Oliveira ACT, Pellegrini JAS, Boniatti MM. Prognostic value of Doppler waveform analysis of common femoral vein in septic patients: a prospective cohort study. J Ultrasound. 2023;26(4):871-7. doi: 10.1007/s40477-023-00819-y.
Bosisio NSB, Romero-González G, De Silvestri A, Husain-Syad F, Ferrari F. Doppler-based evaluation of intrarenal venous flow as a new tool to predict acute kidney injury: A systematic review and meta-analysis. Nefrologia (Engl Ed). 2023;43 (Suppl 2):57-66. doi:10.1016/j.nefroe.2023.05.010.
Gupta B, Ahluwalia P, Gupta A, Ranjan N, Kakkar K, Aneja P. Utility of VExUS score in the peri-operative care unit, intensive care unit, and emergency setting-A systematic review. Indian J Anaesth. 2023;67(Suppl 4):S218-S26. doi:10.4103/ija.ija_475_23.
Mahmud S, Koratala A. Assessment of venous congestion by Doppler ultrasound: a valuable bedside diagnostic tool for the new-age nephrologist. CEN Case Rep. 2021;10(1):153-5. doi: 10.1007/s13730-020-00514-5.
Koratala A. A utilização de ultrassom point-of-care na clínica cardiorrenal para melhorar o atendimento ao paciente. J Bras Nefrol. 2021;43(1):135-6. doi: 10.1590/2175-8239-JBN-2020-0234
Argaiz ER, Koratala A, Reisinger N. Comprehensive assessment of fluid status by point-of-care ultrasonography. Kidney360. 2021;2(8):1326-38. doi: 10.34067/KID.0006482020.
Longino A, Martin K, Leyba K, Siegel G, Gill E, Douglas IS, et al. Correlation between the VExUS score and right atrial pressure: a pilot prospective observational study. Crit Care. 2023;27(1):205. doi: 10.1186/s13054-023-04471-0.
Longino A, Martin K, Leyba K, Siegel G, Thai TN, Riscinti M, et al. Prospective evaluation of venous excess ultrasound for estimation of venous congestion. Chest.
Soliman-Aboumarie H, Denault AY. How to assess systemic venous congestion with point of care ultrasound. Eur Heart J Cardiovasc Imaging. 2023;24(2):177-80. doi: 10.1093/ehjci/jeac239.
Assavapokee T, Rola P, Assavapokee N, Koratala A. Decoding VExUS: a practical guide for excelling in point-of-care ultrasound assessment of venous congestion. Ultrasound J. 2024;16(1):48. doi: 10.1186/s13089-024-00396-z.
Seo Y, Iida N, Yamamoto M, Machino-Ohtsuka T, Ishizu T, Aonuma K. Estimation of central venous pressure using the ratio of short to long diameter from cross-sectional images of the inferior vena cava. J Am Soc Echocardiogr. 2017;30(5):461-7. doi:10.1016/j.echo.2016.12.002.
Taniguchi T, Ohtani T, Nakatani S, Hayashi K, Yamaguchi O, Komuro I, et al. Impact of body size on inferior vena cava parameters for estimating right atrial pressure: a need for standardization?. J Am Soc Echocardiogr. 2015;28(12):1420-7. doi: 10.1016/j.echo.2015.07.008.
Via G, Tavazzi G, Price S. Ten situations where inferior vena cava ultrasound may fail to accurately predict fluid responsiveness: a physiologically based point of view. Intensive Care Med. 2016;42(7):1164-7. doi: 10.1007/s00134-016-4357-9.
Kitamura H, Kobayashi C. Impairment of change in diameter of the hepatic portion of the inferior vena cava: a sonographic sign of liver fibrosis or cirrhosis. J Ultrasound Med. 2005;24(3):355-9; quiz 360-1. doi: 10.7863/jum.2005.24.3.355.
Koratala A, Sturgill D. Point-of-care venous Doppler ultrasound in the management of heart failure and hyponatremia. Clin Nephrol. 2021;96(1):63-6. doi: 10.5414/CN110388.
Rola P, Miralles-Aguiar F, Argaiz E, Beaubien-Souligny W, Haycock K, Karimov T, et al. Clinical applications of the venous excess ultrasound (VExUS) score: conceptual review and case series. Ultrasound J. 2021;13(1):32. doi: 10.1186/s13089-021-00232-8.
Mullens W, Damman K, Harjola VP, Mebazaa A, Brunner-La Rocca HP, Martens P, et al. The use of diuretics in heart failure with congestion—a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2019;21(2):137-55. doi: 10.1002/ejhf.1369.
Schroedter WB, White JM, Garcia AR, Ellis ME. Presence of lower-extremity venous pulsatility is not always the result of cardiac dysfunction. J. Vasc. Ultrasound. 2014;38(2):71–5. doi: 10.1177/154431671403800201
Anastasiou V, Peteinidou E, Moysidis DV, Daios S, Gogos C, Liatsos AC, et al. Multiorgan Congestion Assessment by Venous Excess Ultrasound Score in Acute Heart Failure. J Am Soc Echocardiogr. 2024;37(10):923-33. doi: 10.1016/j.echo.2024.05.011.
Andrei S, Bahr P-A, Nguyen M, Bouhemad B, Guinot P-G. Prevalence of systemic venous congestion assessed by Venous Excess Ultrasound Grading System (VExUS) and association with acute kidney injury in a general ICU cohort: a prospective multicentric study. Crit Care. 2023;27(1):224. doi: 10.1186/s13054-023-04524-4.
Beaubien-Souligny W, Benkreira A, Robillard P, Bouabdallaoui N, Chassé M, Desjardins G, et al. Alterations in portal vein flow and intrarenal venous flow are associated with acute kidney injury after cardiac surgery: a prospective observational cohort study. J Am Heart Assoc. 2018;7(19):e009961. doi: 10.1161/JAHA.118.009961.
Alberto F, Salvatore G, Martin D, Loreto G, Francesco M, Morelli E, et al. Focus on renal blood flow in mechanically ventilated patients with SARS-CoV-2: a prospective pilot study. J Clin Monit Comput. 2022;36(1):161-7. doi: 10.1007/s10877-020-00633-5.
Spiegel R, Teeter W, Sullivan S, Tupchong K, Mohammed N, Sutherland M, et al. The use of venous Doppler to predict adverse kidney events in a general ICU cohort. Crit Care. 2020;24(1):615. doi: 10.1186/s13054-020-03330-6.
Wiersema R, Kaufmann T, van der Veen HN, de Haas RJ, Franssen CF, Koeze J, et al. Diagnostic accuracy of arterial and venous renal Doppler assessment for acute kidney injury in critically ill patients: a prospective study. J Crit Care. 2020;59:57-62. doi:10.1016/j.jcrc.2020.05.012.
Li Z-T, Huang D-B, Zhao J-F, Li H, Fu S-Q, Wang W. Comparison of various surrogate markers for venous congestion in predicting acute kidney injury following cardiac surgery: A cohort study. J Crit Care. 2024;79:154441. doi: 10.1016/j.jcrc.2023.154441.
Longino AA, Martin KC, Leyba KR, McCormack L, Siegel G, Sharma VM, et al. Reliability and reproducibility of the venous excess ultrasound (VExUS) score, a multi-site prospective study: validating a novel ultrasound technique for comprehensive assessment of venous congestion. Crit Care. 2024;28(1):197. doi: 10.1186/s13054-024-04961-9.