High-Volume Plasma Exchange for Dengue Hemorrhagic Fever Complicated by Acute Renal Failure and Fulminant Hepatic Failure
Main Article Content
Abstract
Dengue hemorrhagic fever is a tropical disease caused by the dengue virus and transmitted by Aedes mosquitoes. The disease is spreading across the tropical and subtropical regions of the world, and Thailand is currently experiencing a major outbreak. While a substantial number of patients who are infected with dengue might not have any signs or symptoms, a certain number of patients may develop severe dengue or dengue shock syndrome. Acute kidney failure and acute liver failure are uncommon complications of dengue hemorrhagic fever; however, both are usually fatal. At present, there is an absence of an established strategy for managing acute liver failure in individuals with dengue infection. Plasma exchange is the preferred therapeutic technique for treating patients with acute liver failure who have not received a liver transplant. This article presents a case study and a review of the literature on dengue hemorrhagic fever complicated by acute renal and hepatic failure. High-volume plasma exchange has shown favorable outcomes, promoting recovery of kidney and liver function and enabling safe hospital discharge.
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
This article is published under CC BY-NC-ND 4.0 license, which allows for non-commercial reuse of the published paper as long as the published paper is fully attributed. Anyone can share (copy and redistribute) the material in any medium or format without having to ask permission from the author or the Nephrology Society of Thailand.
References
กรมการแพทย์. แนวทางการวินิจฉัยและการดูแลรักษาผู้ป่วยโรคไข้เลือดออกเดงกีในผู้ใหญ่ พ.ศ.2563.
Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW. Brenner & Rector’s the kidney. 11th ed. Philadelphia: Elsevier. 2020.
กองระบาดวิทยา. สถานการณ์โรคไข้เลือดออก พ.ศ. 2566 [อินเทอร์เน็ต].เข้าถึงได้จาก: https://lookerstudio.google. com/reporting/dfa7d4e2-b7f5-48ed-b40a-54f1cd4cbdfb/page/cFWgC?s=uJijraAskGk
Vachvanichsanong P, Thisyakorn U, Thisyakorn C. Dengue hemorrhagic fever and the kidney. Arch Virol. 2016 ;161(4):771–8. doi: 10.1007/s00705-015-2727-1.
Vachvanichsanong P, McNeil E. Electrolyte disturbance and kidney dysfunction in dengue viral infection. Southeast Asian J Trop Med Public Health. 2015:46 Suppl 1:108-17.
Vasanwala FF, Puvanendran R, Ng JM, Suhail SM. Two cases of self-limiting nephropathies secondary to dengue haemorrhagic fever. Singapore Med J. 2009;50(7):e253-5.
Mallhi TH, Sarriff A, Adnan AS, Khan YH, Hamzah AA, Jummaat F, et al. Dengue-induced acute kidney injury (DAKI): a neglected and fatal complication of dengue viral infection—a systematic review. J Coll Physicians Surg Pak. 2015;25(11):828-34.
Boonpucknavig V, Bhamarapravati N, Boonpucknavig S, Futrakul P, Tanpaichitr P. Glomerular changes in dengue hemorrhagic fever. Arch Pathol Lab Med. 1976;100(4):206–12.
Boonpucknavig V, Soontornniyomkij V. Pathology of renal diseases in the tropics. Semin Nephrol. 2003;23(1):88-106. doi: 10.1053/snep.2003.50008.
Suzuki S, Kitazawa T, Ota Y, Okugawa S, Tsukada K, Nukui Y, et al. Dengue Hemorrhagic Shock and Disseminated Candidiasis. Intern Med. 2007;46(13):1043-6. doi: 10.2169/internalmedicine.46.6354.
Guzmán MG, Alvarez M, Rodríguez R, Rosario D, Vázquez S, Vald s L, et al. Fatal dengue hemorrhagic fever in Cuba, 1997. Int J Infect Dis. 1999;3(3):130–5. doi: 10.1016/s1201-9712(99)90033-4.
Jessie K, Fong MY, Devi S, Lam SK, Wong KT. Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization. J Infect Dis. 2004;189(8):1411-8. doi: 10.1086/383043.
Leowattana W, Leowattana T. Dengue hemorrhagic fever and the liver. World J Hepatol. 2021;13(12):1968–76. doi: 10.4254/wjh.v13.i12.1968.
Mon KK, Nontprasert A, Kittitrakul C, Tangkijvanich P, Leowattana W, Poovorawan K. Incidence and clinical outcome of acute liver failure caused by dengue in a hospital for tropical diseases, Thailand. Am J Trop Med Hyg. 2016;95(6):1338–44. doi: 10.4269/ajtmh.16-0374.
Kangwanpong D, Bhamarapravati N, Lucia HL. Diagnosing dengue virus infection in archived autopsy tissues by means of the in situ PCR method: a case report. Clin Diagn Virol. 1995;3(2):165–72. doi: 10.1016/0928-0197(94)00032-p.
Huerre MR, Lan NT, Marianneau P, Hue NB, Khun H, Hung NT, et al. Liver histopathology and biological correlates in five cases of fatal dengue fever in Vietnamese children. Virchows Arch. 2001;438(2):107–15. doi: 10.1007/s004280000329.
Courageot MP, Catteau A, Desprès P. Mechanisms of dengue virus-induced cell death. Adv Virus Res. 2003;60:157–86. doi: 10.1016/s0065-3527(03)60005-9.
Sung JM, Lee CK, Wu-Hsieh BA. Intrahepatic infiltrating NK and CD8 T cells cause liver cell death in different phases of dengue virus infection. PLoS One. 2012;7(9):e46292. doi: 10.1371/journal.pone.0046292.
Manh DH, Weiss LN, Thuong NV, Mizukami S, Dumre SP, Luong QC, et al. Kinetics of CD4+ T helper and CD8+ effector T cell responses in acute dengue patients. Front Immunol. 2020;11:1980. doi: 10.3389/fimmu.2020.01980.
Kuczera D, Assolini JP, Tomiotto-Pellissier F, Pavanelli WR, Silveira GF. Highlights for dengue immunopathogenesis: antibody-dependent enhancement, cytokine storm, and beyond. J Interferon Cytokine Res. 2018;38(2):69–80. doi: 10.1089/jir.2017.0037.
Fernando S, Wijewickrama A, Gomes L, Punchihewa CT, Madusanka SDP, Dissanayake H, et al. Patterns and causes of liver involvement in acute dengue infection. BMC Infect Dis. 2016;16:319. doi: 10.1186/s12879-016-1656-2.
Gupta M, Gupta S, Sood D, Gupta A, Jesrani G. Role of N-acetylcysteine in liver injury due to dengue fever. Trop Doct. 2023;53(4):475–80. doi: 10.1177/00494755231176317.
Mumtaz K, Azam Z, Hamid S, Abid S, Memon S, Shah HA, et al. Role of N-acetylcysteine in adults with non-acetaminophen-induced acute liver failure in a center without the facility of liver transplantation. Hepatol Int. 2009;3(4):563–70. doi: 10.1007/s12072-009-9151-0.
Fisher C, Health A, Wendon J. Extracorporeal Liver Support Devices. In book: Critical Care Nephrology. 2017;793–799.e2. doi: 10.1016/B978-0-323-44942-7.00130-8.
Larsen FS, Schmidt LE, Bernsmeier C, Rasmussen A, Isoniemi H, Patel VC, et al. High-volume plasma exchange in patients with acute liver failure: an open randomised controlled trial. J Hepatol. 2016;64(1):69-78. doi: 10.1016/j.jhep.2015.08.018.
Connelly-Smith L, Alquist CR, Aqui NA, Hofmann JC, Klingel R, Onwuemene OA, et al. Guidelines on the use of therapeutic apheresis in clinical practice – evidence-based approach from the writing committee of the American Society for Apheresis: the ninth special issue. J Clin Apher. 2023;38(2):77–278. doi: 10.1002/jca.22043.
Nakaviroj S. First case report of high volume therapeutic plasma exchange as a rescue therapy in dengue hemorrhagic fever with acute liver failure. Chula Med J. 2021;65(3):335–8.