Antimicrobial resistant Klebsiella pneumoniae in cancer patients at Maha Vajiralongkorn Thanyaburi Hospital
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Abstract
The research focused on investigating drug-resistant infections at Mahavajiralongkorn Thunyaburi Hospital, where Klebsiella pneumoniae was identified as the primary pathogen. A retrospective cohort study was conducted with the objective of identifying factors linked to the development of Klebsiella pneumoniae drug resistance among cancer patients between October 1, 2021, and September 30, 2024. Thirty-two participants were enrolled, consisting of 13 cases with drug resistance and 19 without. Of these, 76.9% were male and 23.0% were female. Among the 19 non-drug-resistant cases, 73.7% were male and 26.3% were female. The study found no significant difference in the rates of interventions such as enteral feeding, gastrostomy, colostomy, nasogastric tube (NG tube), and tracheostomy tube (TT tube) between the drug-resistant and non-drug-resistant groups (P>0.05). However, urinary catheterization showed a noteworthy contrast, with 53.85% of patients with Klebsiella pneumoniae infection and drug resistance having catheters compared to 5.26% without drug resistance, displaying statistically significant differences (P=0.003) with a risk ratio of 3.5 (RR 3.5, 95% CI 1.66-7.34). Furthermore, patients with a history of drug-resistant infections were significantly more prevalent in the drug-resistant group (69.23%) compared to the non-drug-resistant group (0%) (P<0.001), with a risk ratio of 5.6 (RR 5.6, 95% CI 2.35-14.01). Understanding the factors associated with drug-resistant Klebsiella pneumoniae infections in cancer patients can inform surveillance and management strategies effectively.
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