Ventricular arrhythmia after aortic declamping during heart valve surgery: Comparison between Custodiol cardioplegia and cold blood cardioplegia

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Prawpan Suwanakitch
Maratee Boonmuang
Natcha Thongkon
Wanita Sribunpheng
Arthit Juncome
Kanthachat Thatsakorn


The purpose of this retrospective study was to investigate the incidence of ventricular arrhythmias after aortic declamping and the outcomes of custodial cardioplegia compared with blood CPG in patients undergoing single heart valve surgery, double heart valve surgery and triple heart valve surgery. Method: data were collected from the medical record database of heart valve surgery patients at Naresuan University Hospital in Phitsanulok province from 2015 - 2021. The participants were patients undergoing heart valve surgery, received custodiol cardioplegia or blood cardioplegia, aged between 20 - 70 years and selective random sampling according to the inclusion and exclusion criteria. The research instruments were a general information and a surgical information form. The results showed that the total number of heart valve surgery was 105 patients, 59 single heart valve surgery, 33 double heart valve surgery and 13 triple heart valve surgery. The rate of ventricular arrhythmias in single heart valve surgery who received custodial cardioplegia was significantly higher than those received cold blood cardioplegia (6 (25.00):1(2.90); p = 0.010). The propensity for ventricular arrhythmias was in the same direction as patients undergoing double and triple heart valve surgery. The outcome of using both cardioplegia solution in patients undergoing single, double and triple heart valve surgery including Intra-aortic balloon pump, ICU stay, and hospital length of stay was found to be no different.

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Suwanakitch P, Boonmuang M, Thongkon N, Sribunpheng W, Juncome A, Thatsakorn K. Ventricular arrhythmia after aortic declamping during heart valve surgery: Comparison between Custodiol cardioplegia and cold blood cardioplegia. JMPH4 [Internet]. 2024 Jun. 11 [cited 2024 Jul. 13];14(2):25-34. Available from:
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