Neonatal Alloimmune Thrombocytopenia Associated with HLA-A11 Alloantibody

Authors

  • Pimlak Charoenkwan Department of Pediatrics
  • Rungrote Natesirinilkul Department of Pediatrics
  • Nipapan Leetrakool Blood Bank Section, Faculty of Medicine, Chiang Mai University, Chiang Mai
  • Sucheela Chomsook Blood Bank Section, Faculty of Medicine, Chiang Mai University, Chiang Mai
  • Pawinee Kupatawintu National Blood Centre, Thai Red Cross Society, Bangkok
  • Somporn Chotinaruemol Department of Pediatrics

Keywords:

HLA antibody, Human leukocyte antigen, NAIT, Neonatal alloimmune thrombocytopenia

Abstract

Neonatal alloimmune thrombocytopenia (NAIT) is a result of platelet destruction by maternal antibodies
directed against paternally-inherited antigens on neonatal platelets. NAIT is mostly caused by antibodies to
human platelet antigens (HPA). This is a report of a term newborn with NAIT associated with an antibody to the
human leukocyte antigens (HLA). The newborn presented with cutaneous bleeding at 5 days of age. The lowest
platelet count was 36.8x109/L. An antibody to HLA-A11 was present in maternal serum while HPA antibodies
were not detected. The HLA-A11 antigen was identified in the patient, sister, and father, but not the mother.
The newborn received intravenous immunoglobulin and had a favorable outcome.

Downloads

Download data is not yet available.

Downloads

Issue

Vol. 25 No. 2: April-June 2015

Section

รายงานผู้ป่วย (Case report)