The Stability of Fibrin Glue

Authors

  • Ampaiwan Chuansumrit Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Parttraporn Isarangkura Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Samart Pakakasama Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Somporn Wangruangsathit Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Pimpun Tardtong Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Phongjan Hathirat Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University

Keywords:

Fibrin glue, Tranexamic acid, Thrombin, Cryoprecipitate

Abstract

Abstract: The mixture of cryoprecipitate and tranexamic acid (50 mgimi) by the ratto of 4:1, 3:1 and 2.3:1 were prepared. Then 0.5 ml of mixture of thrombin (250 units ) and calcium chloride (40 mmol/L) were added into the equal volume of the cryopracipitate mixture. Fibrin glue developed immediataly. However, the 4:1 midure of cryoprecipitate and tranexamic acid yielded the most stable flue. The The fibrinolysis was intiated at 180 hours and completely dissolved in 24 hours in the waterbath of 37 C. The final concentration of tranexamic acid in the in-house fibrin glue 5 mg/mL as compared to the reported flbrin glue which were equal to 10-50 mg/mL. The in-house fibrin glue was stable and of low cost.

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References

Lupinetti FM, Stoney WS, Alford WC, et al. Cryoprecipitate-topical thrombin glue. Initial experience in patients undergo cardiac operation. J Thorac Cardiovasc Surg 1988;90:502-5.

Martinowitz U, Mazar AL, Taicher S, et al. Dental extraction for patients on oral anticoagulant therapy. Oral Surg Oral Med Oral Pathol 1990;70(3):274-7.

Martinowitz U, Schulman S. Fibrin sealant in surgery of patients with a hemorrhagic diathesis. Thrombosis and Haemostasis 1995;74(1):486-92.

Rackocz M, Mazar AL, Varon D, et al. Dental extractions in patients with bleeding disorders. The use of fibrin glue. Oral Surg Oral Med Oral Pathol 1993;75(3):280-2.

Suwannuraks M, Chuansumrit A, Sriudompom N. The use of fibrin glue as an operating sealant in dental extraction of bleeding disorder patients. Haemophilia 1996;2(suppl 1):47.

ไพโรจน์ กายพงษ์ศักดิ์, รัชนี โอเจริญ. Autologous fbrin polymers in mandibular reconstruction and its clinical applications. ใน : พิมล เชี่ยวศิลป์, สร้อยสอางค์ พิสด, บรรณาธิการ. คำบรรยายการประชุมทางวิชาการ ของศูนย์บริการโลหิตแห่งชาติ สภากาชาดไทย เล่มที่ 23 พ.ศ. 2536. หน้า 55-63.

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Published

2018-12-30

Issue

Vol. 7 No. 4: October-December 1997

Section

นิพนธ์ต้นฉบับ (Original article)

License

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