Navigating myeloproliferative neoplasms during pregnancy: from preconception to postpartum
DOI:
https://doi.org/10.69898/jhtm.35.2025.279920Keywords:
myeloproliferative neoplasms, Pregnancy, Thrombosis, Aspirin, interferon-alphaAbstract
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Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia. 2022;36:1703-19.
Spivak JL. Myeloproliferative Neoplasms. N Engl J Med. 2017;376:2168-81.
Goulart H, Masarova L, Mesa R, Harrison C, Kiladjian JJ, Pemmaraju N. Myeloproliferative neoplasms in the adolescent and young adult population: A comprehensive review of the literature. Br J Haematol. 2024;205:48-60.
Harris Z, Kaizer H, Wei A, Karantanos T, Williams DM, Chaturvedi S, et al. Characterization of myeloproliferative neoplasms in the paediatric and young adult population. Br J Haematol. 2023;201:449-58.
England JT, Szuber N, Sirhan S, Dunne T, Cerquozzi S, Hill M, et al. Clinical Features and Long-Term Outcomes of a Pan-Canadian Cohort of Adolescents and Young Adults with Myeloproliferative Neoplasms: A Canadian MPN Group Study. Leukemia. 2024;38:570-8.
Landtblom AR, Andersson TM, Johansson ALV, Wendel SB, Lundberg FE, Samuelsson J, et al. Pregnancy and childbirth outcomes in women with myeloproliferative neoplasms-a nationwide population-based study of 342 pregnancies in Sweden. Leukemia. 2022;36:2461-7.
Mathews TJ, Hamilton BE. Mean Age of Mothers is on the Rise: United States, 2000-2014. NCHS Data Brief. 2016:1-8.
Dores GM, Curtis RE, Linet MS, Morton LM. Cause-specific mortality following polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the US population, 2001-2017. Am J Hematol. 2021;96:E451-E4.
Rungjirajittranon T, Owattanapanich W, Ungprasert P, Siritanaratkul N, Ruchutrakool T. A systematic review and meta-analysis of the prevalence of thrombosis and bleeding at diagnosis of Philadelphia-negative myeloproliferative neoplasms. BMC Cancer. 2019;19:184.
Tefferi A, Vannucchi AM, Barbui T. Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management. Am J Hematol. 2024;99:697-718.
Tremblay D, Kremyanskaya M, Mascarenhas J, Hoffman R. Diagnosis and Treatment of Polycythemia Vera: A Review. JAMA. 2025;333:153-60
Bagot CN, Leishman E, Onyiaodike CC, Jordan F, Gibson VB, Freeman DJ. Changes in laboratory markers of thrombotic risk early in the first trimester of pregnancy may be linked to an increase in estradiol and progesterone. Thromb Res. 2019;178:47-53.
Heit JA, Kobbervig CE, James AH, Petterson TM, Bailey KR, Melton LJ, 3rd. Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study. Ann Intern Med. 2005;143:697-706.
Robinson S, Ragheb M, Harrison C. How I treat myeloproliferative neoplasms in pregnancy. Blood. 2024;143:777-85.
Alimam S, Bewley S, Chappell LC, Knight M, Seed P, Gray G, et al. Pregnancy outcomes in myeloproliferative neoplasms: UK prospective cohort study. Br J Haematol. 2016;175:31-6.
Landtblom AR, Andersson TM, Johansson ALV, Lundberg FE, Samuelsson J, Bjorkholm M, et al. Childbirth rates in women with myeloproliferative neoplasms. Leukemia. 2024;38:1081-5.
Maze D, Kazi S, Gupta V, Malinowski AK, Fazelzad R, Shah PS, et al. Association of Treatments for Myeloproliferative Neoplasms During Pregnancy With Birth Rates and Maternal Outcomes: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2:e1912666.
Gangat N, Tefferi A. Myeloproliferative neoplasms and pregnancy: Overview and practice recommendations. Am J Hematol. 2021;96:354-66.
Skeith L, Carrier M, Robinson SE, Alimam S, Rodger MA. Risk of venous thromboembolism in pregnant women with essential thrombocythemia: a systematic review and meta-analysis. Blood. 2017;129:934-9.
Wille K, Brouka M, Bernhardt J, Rufer A, Niculescu-Mizil E, Gotic M, et al. Outcome of 129 Pregnancies in Polycythemia Vera Patients: A Report of the European LeukemiaNET. Hemasphere. 2023;7:e882.
Gangat N, Singh A, Ilyas R, Loscocco GG, Elliott M, Begna K, et al. Aspirin therapy is associated with a lower risk of pregnancy loss in both JAK2- and CALR-mutated essential thrombocythemia-A Mayo Clinic study of 200 pregnancies. Am J Hematol. 2024;99:1862-9.
How J, Leiva O, Bogue T, Fell GG, Bustoros MW, Connell NT, et al. Pregnancy outcomes, risk factors, and cell count trends in pregnant women with essential thrombocythemia. Leuk Res. 2020;98:106459.
Passamonti F, Randi ML, Rumi E, Pungolino E, Elena C, Pietra D, et al. Increased risk of pregnancy complications in patients with essential thrombocythemia carrying the JAK2 (617V>F) mutation. Blood. 2007;110:485-9.
Rumi E, Bertozzi I, Casetti IC, Roncoroni E, Cavalloni C, Bellini M, et al. Impact of mutational status on pregnancy outcome in patients with essential thrombocytemia. Haematologica. 2015;100:e443-5.
Beauverd Y, Radia D, Cargo C, Knapper S, Drummond M, Pillai A, et al. Pegylated interferon alpha-2a for essential thrombocythemia during pregnancy: outcome and safety. A case series. Haematologica. 2016;101:e182-4.
Chiasakul T, Baker RI. Management of Bleeding, Thrombotic and Pregnancy-Related Complications in Women with Myeloproliferative Neoplasms: A Case-Based Review Focusing on Sex-Specific Challenges. J Clin Med. 2025;14:1537.
Liebelt EL, Balk SJ, Faber W, Fisher JW, Hughes CL, Lanzkron SM, et al. NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea. Birth Defects Res B Dev Reprod Toxicol. 2007;80:259-366.
Barbhaiya M, Zuily S, Naden R, Hendry A, Manneville F, Amigo MC, et al. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. Ann Rheum Dis. 2023;82:1258-70.
How J, Hobbs G. Pregnancy: MPN management before, during, and after pregnancy. Hematology Am Soc Hematol Educ Program. 2024;2024:541-6.
Quenby S, Booth K, Hiller L, Coomarasamy A, de Jong PG, Hamulyak EN, et al. Heparin for women with recurrent miscarriage and inherited thrombophilia (ALIFE2): an international open-label, randomised controlled trial. Lancet. 2023;402:54-61.
Leffert L, Butwick A, Carvalho B, Arendt K, Bates SM, Friedman A, et al. The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants. Anesth Analg. 2018;126:928-44.
Richman JM, Rowlingson AJ, Maine DN, Courpas GE, Weller JF, Wu CL. Does neuraxial anesthesia reduce intraoperative blood loss?: A meta-analysis. J Clin Anesth. 2006;18:427-35.
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