Itraconazole Induced Severe Vincristine Toxicities in Patients with Acute Lymphoblastic Leukemia
Keywords:
Acute lymphoblastic leukemia, Drug interaction, Vincristine, ItraconazoleAbstract
Abstract: Two patients with acute Iymphoblastic leukemia (ALL) while receiving induction chemotherapy comprising of weekly injection of vincristine, doxorubicin and prednisolone had developed unusual severe vincristine toxicities. The events were due to drug interaction between vincristine and itraconazole which were given for antifungal prophylaxis. The symptoms spontaneously subsided
after itraconazole withdrawal.
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