Antithrombin III Deficiency: A Case Report and Review of Literature
Keywords:
Hereditary, Thrombophilia, Antithrombin III deficiencyAbstract
Abstract: Hereditary thrombophilia is a genetic tendency to venous thromboembolism. Clinical features suggesting this condition include thrombosis occuring at voung age, a positive family history of thrombosis, thrombosis at unusual sites, or recurrent thrombosis. We rebort a 26-year-old female with 17 weeks of pregnancy presented with severe headache for two days, then developed alteration of consciousness and global aphasia. Brain CT scan revealed hemorthagic infarction at temporoparietal region with brain edema. Surgery was performed to remove blood clot andthrombosis of vein of Labbe's was detected with good recovery. Three days after operation, shedeveloped deep vein thrombosis of right leg and was treated with low molecular weight heparin. Hereditary thromboolia was suspected and so blood samples were obtained from her and her family for evaluation. The
diagnosis was antithrombin II deficiency due to her low plasma antithrombin II level. Her mother, sister and brother also carry this abnormal gene but her father does not. Her mother and sister are asymptomatic but her brother developed deep vein thrombosis and pulmonary embolism 1 month after this event. The thrombosis in this case may be precipitated by pregnancy and surgery.
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