Congenital Bilateral Neuroblastoma Presenting with Hepatic Failure
Keywords:
Congenital neuroblastoma, Hepatic failureAbstract
Abstract: We report a case of male neonate with anemia, abdominal mass, hemorrhagic complications, disseminated intravascular coagulation (DIC) and hepatic failure. Sonography of whole abdomen showed solid bilateral suprarenal masses. He died from uncontrolled bleedings, hepatic failure and renal failure. His autopsy revealed bilateral abdominal neuroblastoma with metastases to liver, lungs, thymus, lymph nodes but no bone marrow involvement. Congenital bilateral neuroblastoma stage I was diagnosed. This disease is quite rare. The possibility of neuroblastoma should be considered when there are hemorhagic complications and hepatic failure in neonate with solid echogenic suprarenal mass.
Downloads
References
Rubinstein SC, Benacerraf BR, Retik AB, et al. Fetal suprarenal masses: sonographic appearance and differential diagnosis. UItrasound Obstet Gyneco! 1995;5164-7.
Kramar SA, Bradford WD, Anderson EE. Bilateral adrenal neuroblastoma. Cancer 1980;45:2208-2.
Murphy TVM,Irving IM, Lister J. Massive adrenal hemorrhage in neonatal neuroblastoma. J Pediatr Surg 1978:13.01-4.
Cassady C, Winters WD. Bilateral cystic neuroblastoma: imaging features and differential diagnoses. Pediatr Radiol 1997:27:758-9.
Chen CP, Chen SH, Chuang CY, Lee HC, Hwu YM, Chang PY, et aLl. Clinical and perinatal sonographic features of congenital adrenal cystic neuroblastoma: a case report with review of the literature. UItrasound Obstet Gynecol 199710:68-73
Sherazi ZA, Mireaus CD. Suprarenal cystic masses: unusual causes. Clin Radiol 1997;52:953-5.
Richards ML, Gundersen AE, Williams MS. Cystic neuroblastoma of infancy. J Pediatr Surg 1995;30:1354-7.
Croitoru DP, Sinsky AB, Laberge JM. Cystic neuroblastoma. J Pediatr Surg 1992:27:1320-1.
Jennings RW, LaQuaglia MP, Leong K, Hendren WH, Adzick NS. Fetal neuroblastoma: prenatal diagnosis and natural history. J Pediatr Surg 1993:28:1168-74.
Acharya S, Jayabose S, Kogan SJ, Tugal O, Beneck D, Leslie D, et al. Prenatally diagnosed neuroblastoma. Cancer 199780:304-10.
Lanzkosky P. Neuroblastoma. Manual of pediatric hematology and oncology. 3' ed. California : Academic Press, 2000:493-512.
Ravasi F, Gasser B, Collina G, Massolo F, Philippe E. Congenital fetal neuroblastoma. Ann Pathol 2001;21:76-80.
Brodeur GM, Castleberry RP. Neuroblastoma. In: Pizzo PA, Poplack DG, editors. Principle and Practice of Pediatric Oncology. 3rd ed. Philadelphia : JB Lippincott; 1997:761-97.
Lindner W, Behnisch W, Urich K, Debatin KM, Pohladt F. Congenital neuroblastoma mimicking early onset sepsis. Eur J Peditr 2001;160:436-8.
Goldstein I, Gomez K, Copel JA. The real-time and color Doppler appearance of adrenal neuroblastoma in a third-trimester fetus. Obstet Gynecol 1994;83:854-5.
Deeg KH, Bettendorf U, Hofmann V. Differential diagnosis of neonatal adrenal hemorrhage and congenital neuroblastoma by color-coded Doppler sonography. Eur J Pediatr 1998;57:294-7.
Vora D, Slovis TL, Boal DKB. Hemoperitoneum and disseminated intravascular coagulation in two neonates with congenital bilateral neuroblastoma. Pediatr Radiol 2000:30:394-7.
Siegel MJ. Pediatric application. In: Lee JKT, Sagel SS, Stanley RJ, editors. Computed body tomography with MRI correlation. 3rd ed. Philadelphia : Lippincott-Raven, 1998:1493-560.
Dahnert W. Renal, adrenal ureteral, vesicle and scrotal disorders. In: Dahnert W, editor. Radiology review manual. 3rd ed. Baltimore : Williams& Wilkins, 1996.659-714.
Thompson EN, Bosley A. Disseminated intravascular coagulation in association with congenital neuroblastoma. Postgrad Med J 1979:55:814-7.
Steinmetz JC. Neonatal hypertension and cardiomegaly association with a congenital neuroblastoma. Pediatr Patho 1989:9:577-82.
Lee SY, Chuang JH, Huang CB, et al. Congenital bilateral cystic neuroblastoma with liver metastases and massive intracystic haemorrhage. Bri J Radiol 1998.71:1205-7.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
