การกระจายของมะเร็งต่อมน้ำเหลือง non-Hodgkin’s มาที่ระบบประสาทส่วนกลาง

Authors

  • Thirabhat Chitsobhak Division of Hematology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Vichai Atichartakarn Division of Hematology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Saengsuree Jootar Division of Hematology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Suporn Chuncharunee Division of Hematology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Artit Ungkanont Division of Hematology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Pantep Angchaisuksiri Division of Hematology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Surapon Worapongpaiboon Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Sayomporn Sirinavin Sirinavin Division of Clinical Epidemiology, Faculty of Medicine, Ramathibodi Hospital
  • Sasivimol Rattanasiri Division of Clinical Epidemiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Ammarin Thakkinstian Division of Clinical Epidemiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University

Keywords:

Central nervous system, Non-Hodgkin's lymphomas

Abstract

Abstract: To determine the incidence and risk factors of central nervous system (CNS) involvement in adult patients with non-Hodgkin's lymphomas (NHL), three hundred and thirty three patients with biopsy-proven NHL treated at Ramathibodi hospital between January 1997 to June 2002 were reviewed. The incidence rate of CNS involvement in NHL was 5 /100 patients/year. The probability of CNS involvement at 1 and 3 years after diagnosis of NHL were 7.24% (95% Confidential Interval (CI): 4.52, 11.49) and 13.62% (95% CI: 8.88, 20.60), respectively. Cox regression analysis showed that elevated serum LDH levels (Hazard ratio (HR) 17.61, 95% CI: 3.23, 95.96), lymphomatous involvements of the bone marrow (HR 4.95, 95% CI: 1.91, 12.78), sinonasal area (HR 5.98, 95% CI: 1.86, 19.20), orbit (HR 23.38, 95% CI: 5.24, 104.32), and reproductive organs (HR 36.93, 95% CI: 8.87, 153.81) were significantly associated with CNS involvement in NHL.

Downloads

Download data is not yet available.

References

Recht L, Straus DJ, Cinincione C, et al. Central nervous system metastases from non-Hodgkin's lymphoma:treatment and prophylaxis. Am J Med 1988;84:825-35.

van Besien, Cabanillas F. Clinical manifestation and treatment of non-Hodgkin's Lymphoma. In: Hoffman R, Benz EJ, Shattil SJ, et al, editors. Hematology: Basic principle and practice, 3" edition. Philadelphia: Churchill Livingstone, 2000:1293-339.

van Besien, Ha CS, Murphy S, et al. Risk factors, treatment, and outcome of central nervous system

recurrence in adults with intermediate-grade and immunoblastic lymphoma. Blood 1998;91:1178-84.

Tomita N, Kodama F, Sukai R, et al. Predictive factors for central nervous system involvement in non-Hodgkin's lymphoma: significance of very high serum LDH concentration. Leuk Lymphoma 2000;38:335-43.

Herman TS, Hammond N, Jones SE, et al. Involvement of the central nervous system by non Hodgkin's lymphoma. Cancer 1979;43:390-7.

Mackintosh FR, Colby TV, Podolsky WJ, et al. Central nervous system involvement in non-Hodgkin's lymphoma: an analysis of 105 cases. Cancer 1982;49:586-95.

Ribrag V, Bibeau F, Weshi E, et al. Primary breast lymphoma: a report of 20 cases. Br J Haematol 2001;115:253-6.

Liang R, Chiu E, Loke SL. Secondary central nervoussystem involvement by non-Hodgkin's lymphomas: The risk factors. Hematol Oncol 19908:141-6.

Intragumtornchai T, Wannakrairoj P, Chaimongkol B, et al. Non-Hodgkin's lymphomas in Thailand. Cancer 1996:78:1813-9.

Shipp MA, Harrington DP, Anderson JR, et al. A predictive model for aggressive non-Hodgkin's lymphoma. N Engl J Med 1993;329:987-94.

Stata Corp. 2001 Stata statistical software: Release 7.0. College station, Tx : Stata Corporation.

Leelarodjalek V, Lekhakula A. Neurologic complications in adult hematologic malignancies in Sonklanagarind hospital: prevalence and clinical pattern. Thai J Hematol Transf Med 1998;8:9-21.

Bollen ELLM, Brouwer RE, Hamers S, et al. Central nervous system relapse in non-Hodgkin's lymphoma. Arch Neurol 1997:54:854-9

Lossos IS, Breuer R, Intrator O, et al. Cerebrospinal fluid lactate dehydrogenase isoenzyme analysis for the diagnosis of central nervous system involvement in hematologic patients. Cancer 2000;88:1599-604

Vang R, Medeiros J, Silva EG. Non-Hodgkin's lymphoma involving the vagina: a clinicopathologic analysis of 14 patients. Am J Surg Pathol 2000;24:719-25.

Perren T, Farrant M, McCarthy K, et al. Lymphomas of the cervix and upper vagina: a report of 5 cases and a review of literature. Gynecol Oncol 1992;44:87-95.

Cheung M, Chan J, Lau W, et al. Primary non-Hodgkin's lymphoma of the nose and nasopharynx: clinical features, tumor immunophenotype and treatment outcome in 113 patients. J Clin Oncol 1998;16:70-7.

Logsdon M, Ha C, Kavadi V, et al. Lymphoma of the nasal cavity and paranasal sinuses. Cancer 1997;80:477-88.

Cavalli F. Extranodal lymphoma. In: Magrath I, editor. The non-Hodgkin's lymphomas, 2"d edition. London: Amold, 1997:1016-7.

Burton G, Atwater S, Borowitz M, Huang A. Extranodal head and neck Iymphoma: prognosis and pattems of recurrence. Arch Otolaryngol Head Neck Surg 1990;116:69-73.

Coupland SE, Krause L, Delecluse HJ, et al. Lymphoproliferative lesions of the ocular adnexa. Ophthalmology 1998;105:1430-41.

Downloads

Published

2022-12-30

Issue

Vol. 14 No. 4: October-December 2004

Section

นิพนธ์ต้นฉบับ (Original article)

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.