Report of a rare case in Thailand: dengue hemorrhagic fever in a female patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency
Keywords:dengue hemorrhagic fever, G6PD deficiency
Glucose-6-phosphate dehydrogenase deficiency is an X-linked recessive disorder, involving decreasing activity of enzyme induced hemolysis. This condition manifests in males more often than females. Therefore, a rare case study is presented as described below.
A 22-year-old female from Bangkok was admitted to the Hospital for Tropical Diseases. She presented fever, chills, headache, anorexia and minimal amount of menstruation (the 3rd day of cycle). Laboratory investigation revealed positive for dengue NS-1 antigen, positive for IgM and IgG antibody, WBC count 2,600 cells/mm3 with atypical lymphocytes 9% and platelet count 17,000 cells/mm3. The doctor diagnosed dengue hemorrhagic fever and found urobilinogen 3+ in urine. G6PD activity showed low G6PD level. This condition can cause hemolysis in dengue infection.
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