Lymphoma of the ocular adnexa: a retrospective study in a tertiary care center

Authors

  • Chanissara Pratchayaprateep Department of Anatomical Pathology, Hatyai Hospital, Hat Yai, Songkhla
  • Pimjai Niparuck Division of Hematology, Department of Internal Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Paisarn Boonsakan Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University

Keywords:

Ocular adnexa, Lymphoma, Pathology, Treatment outcome

Abstract

Background: Ocular adnexal lymphomas (OALs) are a heterogeneous group of lymphoid neoplasm, accounting for approximately 1-2% of nonHodgkin lymphomas and 8%  of extranodal lymphomas. The incidence of tumors has continuously risen. This study aimed to describe the clinicopathologic and immunophenotypic features of OALs.

Material and methods: Twenty-five OAL cases diagnosed in the Department of Pathology, Ramathibodi Hospital, between the years 2007 to 2018 were evaluated retrospectively in terms of clinical data and tumor types. Patient demographics, signs and symptoms, tumor location, stage of disease at diagnosis, and international prognostic index score (IPI score) were evaluated. Pathologic review of all cases was performed according to the WHO classification 4th edition.
Result: The included population in this study was 25 cases with 60% males and a median age of 63 years. Three tumor subtypes, including extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue or MALT lymphoma (92%), small lymphocytic lymphoma (4%) and diffuse large B-cell lymphoma (4%), were identified in this study. The most involved site was the eyelid (48%), followed by the lacrimal gland (35%) and conjunctiva (13%). All cases exhibited a palpable mass on physical examination. Most patients had stage 1 disease on diagnosis with low IPI score and proper treatment outcome.

References

Ferry JA, Fung CY, Zukerberg L, Lucarelli MJ, Hasserjian RP, Preffer FI, et al. Lymphoma of the ocular adnexa: a study of 353 cases. Am J Surg Pathol. 2007;31:170-84.

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, editors. WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon: IARC; 2017.

Grossniklaus HE, Eberhart CG, Kivela TT. WHO Classification of tumors of the eye. 4th ed. Lyon: IARC; 2018.

McKelvie PA, McNab A, Francis IC, Fox R, O’Day J. Ocular adnexal lymphoproliferative disease: a series of 73 cases. Clin Exp Ophthalmol. 2001;29:387-93.

Mulay K, Honavar SG. An update on ocular adnexal lymphoma. Semin Diagn Pathol. 2016;33:164-72.

Sharara N, Holden JT, Wojno TH, Feinberg AS, Grossniklaus HE. Ocular adnexal lymphoid proliferations: clinical, histologic, flow

cytometric, and molecular analysis of Forty-three cases. Ophthalmology. 2003;110:1245-54.

Ozkan MC, Palamar M, Tombuloglu M, Hekimgil M, Ozsan N, Saydam G, et al. Ocular adnexal lymphomas: Single-Center

experience. Clin Lymphoma Myeloma Leuk. 2015;15:158-60.

Downloads

Published

2022-03-24

Issue

Section

นิพนธ์ต้นฉบับ (Original article)