Packing Frozen Plasma Component for Transportation Using Frozen Sodium Chloride Solution

บทคัดย่อ

Abstract :

Introduction: The World Health Organization defines the standard temperature for frozen plasma component transportation as below -18oC within 24 hours. The National Blood Centre recommends using dry ice as a packaging coolant. Therefore, hospitals need to prepare dry ice for receiving blood components. However, dry ice iscostly, cannot be reused, not commonly available especially for provincial hospitals and unsafe in case of careless use. Objective: To prepare ice pack (IP) using Sodium Chloride solution and to study efficiency of prepared ice pack for transporting frozen plasma component that meet standard temperature. Materials and Methods: 10%, 30%, 40% and 50% W/V of NaCl were prepared as IP in PET bottles, then temperature of these frozen Sodium Chloride solution were compared. The temperature of 20 units and 50 units packed FFP and Cryoprecipitate respectively were monitored using IP with outside temperature between 25 - 30oC. After that, these prepared FFP were carried by bus to the Lopburi Regional Blood Centre. Results: 1.5 kilograms for one bottle of frozen 40% W/V Sodium Chloride solution (IPC) could reach and keep at -22.6oC as the lowest temperature. At the 30th minute it still maintained -22.0oC. Packing 20 units FFP used 7 bottles of IPC. Three time-consecutive trials found that the IPC could keep the temperature at below -18.0oC for 13-14 hours. The average temperature inside packaging box was
between -23.2 to -23.8oC and the outside temperature was 29.7 - 30.6oC. While packing 50 units Cryoprecipitate used 8 bottles of IPC. Three time-consecutive trials found that the IPC could keep the temperature at below -18.0oC for 16 - 22 hours. The average temperature inside packaging box was between -22.1 to -22.6oC and the outside temperature was 29.0 - 31.9oC. In addition, these experiments could be used to meet standard temperature requirements in a real situation for 7 hours, with the average temperature while transport was -25.4oC. These blood components were all
in good conditions. Conclusion: IPC can be used instead of dry ice for maintaining the transportation temperature of frozen plasma components effectively. Hospital blood banks, institutes or organizations are able to prepare IPC in an easy way by themselves. Furthermore, IPC is durable and reusable that cause the cost of transportation reduction