A pregnant woman with hypereosinophilia and a neuroendocrine tumor
Keywords:
hypereosinophilia, paraneoplastic eosinophilia, hypereosinophilic syndrome, Neuroendocrine tumorAbstract
Eosinophilia is a common problem in general practice, and the most common cause is reactive condition.
Paraneoplastic eosinophilia is a rare clinical manifestation in neuroendocrine tumors and may be associated
with advanced-stage disease. We highlight the case of a pregnant woman presenting progressive dyspnea and
hepatosplenomegaly. Liver and bone marrow biopsy revealed a metastatic neuroendocrine tumor. Genetic mutation tests for clonal myeloid diseases were negative. The patient did not respond to steroid or cytoreductive drugs. Tissue biopsy is needed to confirm the diagnosis.
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References
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8. Sa A. Wang et al. Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome. Haematologica. 2017;102(8):1352-1360.
2. Amy D. Klion. How I treat hyper eosinophilic syndromes. Blood. 2015;126(9):1069-1077.
3. Samy Sakkal, Sarah Miller, Vasso Apostolopoulos and Kulmira Nurgali. Eosinophils in Cancer: Favourable or Unfavourable?Current Medicinal Chemistry. 2016; 23:650-666.
4. Omar Abughanimeh, Mohammad Tahboub and Mouhanna Abu Ghanimeh. Metastatic Lung Adenocarcinoma Presenting with Hypereosinophilia. Cureus. 2018; 10(6): e2866.
5. Moran Livne Margolin, Nona Zeitlin, Yehudit E. Friedman, Opher Globus and Meir Mouallem MD. Eosinophilia and Leukocytosis in a Patient with Lung Cancer. IMAJ. 2019; 21: 58–59.
6. Hayato Yamauchi, Shinji Sakurai, Ritsuko Tsukagoshi, Masaki Suzuki, Yuichi Tabe, Takaharu Fukasawa, Shinsuke Kiriyama, Minoru Fukuchi, Hiroshi Naitoh and Hiroyuki Kuwano. A Case of Very Well-Differentiated Adenocarcinoma with Carcinoid Tumor in the Ascending Colon. Int Surg. 2014; 99:132–136.
7. Daniel F. Boyer. Blood and Bone Marrow Evaluation for Eosinophilia. Arch Pathol Lab Med. 2016; 140:1060–1067.
8. Sa A. Wang et al. Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome. Haematologica. 2017;102(8):1352-1360.
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Published
2020-06-15
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รายงานผู้ป่วย (Case report)
