แอนติบอดีต่อเกล็ดเลือดในผู้ป่วยโรคเกล็ดเลือดต่ำเรื้อรัง

Abstract

Abstract :

Immune thrombocytopenic purpura (ITP), an autoimmune disease, commonly occurs in children age 1-9 years. Around 20% of all patients develop chronic ITP. However, the diagnosis of chronic ITP may mimic the diagnosis of other thrombocytopenic diseases. Therefore, this study aims to identify the usefulness of platelet associated antibody (PAIgG) for the diagnosis of chronic ITP. This study enrolled 33 children with chronic ITP and 23 controls. The sensitivity and specificity for the diagnosis of chronic ITP when level above 6.09% were 66.7% and 65.2%, respectively. PAIgG level above 22.4% had 100% specificity for the diagnosis of chronic ITP. In addition, PAIgG level had negative correlation with the number of platelet count. Therefore, PAIgG level can be a supportive test for the diagnosis of chronic ITP especially when the level is high.