Prevalence of Thalassemia Traits in People without Anemia or Microcytosis

Authors

  • Somchai Insiripong Hematology Unit, Department of Medicine, Maharat Nakhon Ratchasima Hospital
  • Watcharin Yingsitsiri Hematology Unit, Department of Medicine, Maharat Nakhon Ratchasima Hospital
  • Juree Boondumrongsagul Hematology Unit, Department of Medicine, Maharat Nakhon Ratchasima Hospital
  • Jirawadee Noiwatanakul Hematology Unit, Department of Medicine, Maharat Nakhon Ratchasima Hospital

Keywords:

Thalassemia traits, Mean corpuscular volume, Prevalence

Abstract

Introduction: The mean corpuscular volume (MCV) lower than 80 fL is always used as one clue for screening thalassemia/hemoglobinopathy. Objective: To survey the alpha-thalassemia-1, beta-thalassemia and hemoglobinopathy in the individuals who have normal hemoglobin (Hb) concentration and normal MCV. Materials and Methods: The participants with normal Hb level and normal MCV randomly selected from the physically normal people are investigated for Hb typing and PCR for alpha-thalassemia-1 genotyping. Results: From 152 participants, there are no alpha-thalassemia-1 trait (SEA and Thai types), 24 Hb E traits (15.8 %), 3 Hb Constant-Spring traits (2.0%) and 1 beta thalassemia trait (0.6%) Conclusion: The alpha-thalassemia-1 can be excluded in people with normal Hb concentration and normal MCV.

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Author Biographies

Somchai Insiripong, Hematology Unit, Department of Medicine, Maharat Nakhon Ratchasima Hospital

Watcharin Yingsitsiri, Hematology Unit, Department of Medicine, Maharat Nakhon Ratchasima Hospital

Juree Boondumrongsagul, Hematology Unit, Department of Medicine, Maharat Nakhon Ratchasima Hospital

Jirawadee Noiwatanakul, Hematology Unit, Department of Medicine, Maharat Nakhon Ratchasima Hospital

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Issue

Vol. 24 No. 1: January-March 2014

Section

นิพนธ์ต้นฉบับ (Original article)