Hemophagocytosis lymphohistiocytosis associated with HIV-negative Primary Bone Marrow Hodgkin Lymphoma
Keywords:
Hodgkin hymphoma, Bone marrow, Hemophagocytic syndromeAbstract
Hemophagocytosis lymphohistiocytosis associated with Primary Bone Marrow Hodgkin Lymphoma (PBMHL) is a rare condition that uncommonly seen in clinical practice, especially in HIV-negative patients. Herein, we reported an elderly man manifested with prolonged fever without initial evidence of infection or malignancy. After cytopenia was progressed, he was proceeded to bone marrow examination. Increasing of histiocyte with hemophagocytic activity was reported. Pathology of bone marrow showed atypical Reed Sternberg cells. Immunohistochemical staining was done for diagnosis. Positivity of CD 15, CD 30 and Epstein-Barr virus encoded small RNA (EBER) in situ hybridization in the atypical Reed Sternberg cell suggested Primary Bone Marrow Hodgkin Lymphoma (PBMHL). Chemotherapy ABVD regimen was given as definite treatment.
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