Prevalence and Incidence of Chronic Lower Respiratory Diseases in Farmers: Systematic Review

Main Article Content

Sunettra Pansub
Chetta Ngamjarus

Abstract

This systematic review aimed to estimate prevalence and incidence of chronic lower respiratory diseases, including chronic obstructive pulmonary disease (COPD), airway obstruction, chronic bronchitis, and asthma among agricultural workers. The objective was to estimate the prevalence and incidence of these chronic lower respiratory diseases in farmers. The study conducted a comprehensive literature search from electronic databases including Thai Journals Online (ThaiJO), PubMed, CINAHL, SCOPUS and CENTRAL. Included studies were analyzed using meta-analysis with a random-effects model. The risk of bias was assessed using the JBI Critical Appraisal Checklist for Studies Reporting Prevalence Data. Out of 135 studies that met the inclusion criteria, 125 studies were included in the meta-analysis with a total sample size of 825,713 farmers. The overall prevalence of chronic lower respiratory diseases was as follows: COPD 7% (95% CI: 5-11%), airway obstruction 16% (95% CI: 12-22%), chronic bronchitis 8% (95% CI: 7-10%), and asthma 7% (95% CI: 6-8%). The overall incidence was 14% (95% CI: 9-20%) for COPD and 3% (95% CI: 1-9%) for asthma. The risk of bias assessment of the included studies generally indicated a low risk of bias. Additionally, most of the included studies were conducted in high-income countries (108 studies (80%))

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Pansub S, Ngamjarus C. Prevalence and Incidence of Chronic Lower Respiratory Diseases in Farmers: Systematic Review. JDPC3 [internet]. 2025 Apr. 21 [cited 2025 May 23];19(1):120-38. available from: https://he01.tci-thaijo.org/index.php/JDPC3/article/view/272040
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References

Chronic obstructive pulmonary disease (COPD). Key facts. World Health Organization. [online]. 2021 [cited 29 Mar 2022]. Available from: https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pulmonary-disease-(copd).

COPD: Facts, Statistics, and You. Healthline. [online]. 2021 [cited 29 Mar 2022]. Available from: https://www.healthline.com/health/copd/facts-statistics-infographic.

COPD Death Rates in the United States. Data and Statistics. Chronic Obstructive Pulmonary Disease (COPD). Centers for Disease Control and Prevention (CDC). [online]. 2021 [cited 29 Mar 2022]. Available from: https://www.cdc.gov/copd/data.html.

Asthma. Key facts. World Health Organization. [online]. 2021 [cited 29 Mar 2022]. Available from: https://www.who.int/news-room/fact-sheets/detail/asthma.

Rates of Chronic lower respiratory disease and Occupational asthma. Health Data Center (HDC). Information Technology & Communication Centre. Office of the Permanent Secretary Ministry of Public Health. [online]. 2021 [cited 29 Mar 2022]. Available from: https://hdcservice.moph.go.th/hdc/reports/page.php?cat_id=f16421e617aed29602f9f09d951cce68

Roman-Rodriguez M, Kaplan A. GOLD 2021 Strategy Report: Implications for Asthma-COPD Overlap. Int J Chron Obstruct Pulmon Dis. [online]. 2021 [cited 29 Mar 2022];16:1709-1715. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214338/

GBD 2019 Chronic Respiratory Diseases Collaborators. Global burden of chronic respiratory diseases and risk factors, 1990-2019: an update from the Global Burden of Disease Study 2019. EclinicalMedicine. [online]. 2021. [cited 29 Mar 2022];59:101936. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614570/

Chronic obstructive pulmonary disease. National Center for Farmer Health. [online]. 2021 [cited 29 Mar 2022]. Available from: https://farmerhealth.org.au/2014/03/20/chronic-obstructive-pulmonary-disease

Woldeamanuel GG, Mingude AB, Yitbarek GY, Taderegew MM. Chronic respiratory symptoms and pulmonary function status in Ethiopian agricultural workers: a comparative study. BMC Pulm Med. [online]. 2020. [cited 29 Mar 2022]; 20(1):86. Available from: https://pubmed.ncbi.nlm.nih.gov/32264856/

Rinsky JL, Richardson DB, Kreiss K, Nylander-French L, Beane Freeman LE, London SJ et al. Animal production, insecticide use and self-reported symptoms and diagnoses of COPD, including chronic bronchitis, in the Agricultural Health Study. Environ Int. [online]. 2019. [cited 29 Mar 2022]; 127: 764-772. Available from: https://pubmed.ncbi.nlm.nih.gov/31029031/

Soumagne T, Degano B, Guillien A, Annesi-Maesano I, Andujar P, Hue S et al. Characterization of chronic obstructive pulmonary disease in dairy farmers. Environ Res. [online]. 2020. [cited 29 Mar 2022]; 188: 109847. Available from: https://pubmed.ncbi.nlm.nih.gov/32846639/

Guillien A, Soumagne T, Dalphin JC, Degano B. COPD, airflow limitation and chronic bronchitis in farmers: a systematic review and meta-analysis. Occup Environ Med. [online]. 2019. [cited 29 Mar 2022];76(1):58-68. Available from: https://pubmed.ncbi.nlm.nih.gov/30482880/

Microsoft 365 Insider. Microsoft Excel [software]. Version [2410]. Redmond, WA: Microsoft Corporation; 2024 [cited 29 Mar 2022]. Available from: https://www.microsoft.com/excel

The Joanna Briggs Institute Critical Appraisal tools for use in JBI Systematic Reviews Checklist for Prevalence Studies. The Joanna Briggs Institute. [online]. 2021 [cited 29 Mar 2022]. Available from: https://jbi.global/sites/default/files/2019-05/JBI_Critical_Appraisal-Checklist_for_Prevalence_Studies2017_0.pdf

R Core Team (2024). _R: A Language and Environment for Statistical Computing_.R Foundation for Statistical Computing, Vienna, Austria. <https://www.R-project.org/>.

World Bank Country and Lending Groups. (2023). World Bank Data Help Desk. Retrieved from https://datahelpdesk.worldbank.org/knowledgebase/articles/906519-world-bank-country-and-lending-groups

Woldeamanuel GG, Mingude AB, Yitbarek GY, Taderegew MM. Chronic respiratory symptoms and pulmonary function status in Ethiopian agricultural workers: a comparative study. BMC Pulm Med. [online]. 2020. [cited 29 Mar 2022]; 20(1): 86. Available from: https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-020-1120-3

Soumagne T, Degano B, Guillien A, Annesi-Maesano I, Andujar P, Hue S et al. Characterization of chronic obstructive pulmonary disease in dairy farmers.Environ Res. [online]. 2020. [cited 29 Mar 2022]; 188: 109847. Available from: https://pubmed.ncbi.nlm.nih.gov/32846639/

Stoleski S, Minov J, Karadzinska-Bislimovska J, Mijakoski D, Atanasovska A, Bislimovska D. Asthma and Chronic Obstructive Pulmonary Disease Associated with Occupational Exposure in Dairy Farmers - Importance of Job Exposure Matrices. Open Access Maced J Med Sci. [online]. 2019. [cited 29 Mar 2022];7(14):2350-9. Available from: https://pubmed.ncbi.nlm.nih.gov/31592062/

Szczyrek M, Krawczyk P, Milanowski J, Jastrzębska I, Zwolak A, Daniluk J. Chronic obstructive pulmonary disease in farmers and agricultural workers - an overview. Ann Agric Environ Med. [online]. 2011. [cited 29 Mar 2022]; 18(2):310-3. Available from: https://pubmed.ncbi.nlm.nih.gov/22216804/

Eduard W, Douwes J, Omenaas E, Heederik D. Do farming exposures cause or prevent asthma? Results from a study of adult Norwegian farmers. Thorax. [online]. 2004. [cited 29 Mar 2022]; 59(5): 381-6. Available from: https://pubmed.ncbi.nlm.nih.gov/15115863/

Nuraydın A, Bilek Ö, Kenziman AK, Korkusuz MA, Atagün Aİ, Çakar NÖ et al. The Mersin Greenhouse Workers Study. Surveillance of Work-related Skin, Respiratory, and Musculoskeletal Diseases. Ann Glob Health. [online]. 2018. [cited 29 Mar 2022];84(3):504-511. Available from: https://pubmed.ncbi.nlm.nih.gov/30835382/

Li J, Li Y, Tian D, Yang H, Dong L, Zhu L. The association of self-reported respiratory system diseases with farming activity among farmers of greenhouse vegetables. J Int Med Res. [online]. 2019. [cited 29 Mar 2022] ;20(1):86. Available from: https://pubmed.ncbi.nlm.nih.gov/31179805/

Eduard W, Pearce N, Douwes J. Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents. Chest. [online]. 2009. [cited 29 Mar 2022]; 136(3): 716-725. Available from: https://pubmed.ncbi.nlm.nih.gov/19318669/

Guillien A, Soumagne T, Dalphin JC, Degano B. COPD, airflow limitation and chronic bronchitis in farmers: a systematic review and meta-analysis. Occup Environ Med. [online]. 2019. [cited 29 Mar 2022]; 76(1): 58-68. Available from: https://pubmed.ncbi.nlm.nih.gov/30482880/

Fontana L, Lee SJ, Capitanelli I, Re A, Maniscalco M, Mauriello MC, Iavicoli I. Chronic Obstructive Pulmonary Disease in Farmers:A Systematic Review. J Occup Environ Med. [online]. 2017. [cited 25 Aug 2024]; 59(8): 775-788. Available from: https://pubmed.ncbi.nlm.nih.gov/28594705/

Stoleski S, Minov J, Karadzinska-Bislimovska J, Mijakoski D, Atanasovska A, Bislimovska D. Work-related Asthma in Crop Farmers. Open Access Maced J Med Sci. [online]. 2020. [cited 25 Aug 2024]; 8(E): 528-537. Available from: https://repository.ukim.mk/handle/20.500.12188/9691

Eduard W, Pearce N, Douwes J. Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents. Chest. [online]. 2009. [cited 29 Mar 2022]; 136(3):716-725. Available from: https://pubmed.ncbi.nlm.nih.gov/19318669/

Szczyrek M, Krawczyk P, Milanowski J, Jastrzębska I, Zwolak A, Daniluk J. Chronic obstructive pulmonary disease in farmers and agricultural workers - an overview. Ann Agric Environ Med. [online]. 2011. [cited 29 Mar 2022]; 18(2):310-3. Available from: https://pubmed.ncbi.nlm.nih.gov/22216804/

Eduard W, Douwes J, Omenaas E, Heederik D. Do farming exposures cause or prevent asthma? Results from a study of adult Norwegian farmers. Thorax. [online]. 2004. [cited 29 Mar 2022]; 59(5):381-6. Available from: https://pubmed.ncbi.nlm.nih.gov/15115863/

Jouneau S, Chapron A, Ropars C, Marette S, Robert AM, Gouyet T et al. AIRBAg research group. Prevalence and risk factors of asthma in dairy farmers: Ancillary analysis of AIRBAg. Environ Res. [online]. 2022. [cited 29 Mar 2022]; 214(Pt 4):114145. Available from: https://hal.science/hal-03776388

Toluwalase Janet Ogunleye, Adewale Matthew Taiwo, Temilade Fola Akinhannmi, Laoye Oluwafemi Oyediran, Toyin Ayodele Arowolo. Assessment of air quality, health status and lung function of workers from selected poultry management systems in Ogun State, Nigeria. Clinical Epidemiology and Global Health. [online]. 2022. [cited 29 Mar 2022];18:101159. Available from: https://www.sciencedirect.com/science/article/pii/S2213398422002019

L. de Graaf, M. Talibov, M. Boulanger, M. Bureau, E. Robelot, P. Lebailly et al. Health of greenspace workers: Morbidity and mortality data from the AGRICAN cohort. Environmental Research. [online]. 2022. [cited 29 Mar 2022];212:113375. Available from: https://www.sciencedirect.com/science/article/pii/S0013935122007022

Lee S, Han J, Woo SH, Lee SJ. Occupational factors affecting the decline in pulmonary function among male farmers using occupational pesticide in Gyeonggi-do, South Korea. Ann Occup Environ Med. [online]. 2022. [cited 29 Mar 2022];34: e42. Available from: https://pubmed.ncbi.nlm.nih.gov/36704539/

Babaoglu, U.T., Oymak Yalcin, S., Calis, A.G. et al. Effects of different occupational exposure factors on the respiratory system of farmers: the case of Central Anatolia. J Public Health (Berl.). [online]. 2022. [cited 29 Mar 2022];30:2123–2131. Available from: https://link.springer.com/article/10.1007/s10389-021-01554-6

Silver SR, Alarcon WA, Li J. Incident chronic obstructive pulmonary disease associated with occupation, industry, and workplace exposures in the Health and Retirement Study. Am J Ind Med. [online]. 2021. [cited 29 Mar 2022];64(1):26-38. Available from: https://pubmed.ncbi.nlm.nih.gov/33124723/

Gao H, Niu Y, Wang Q, Shan G, Ma C, Wang H et al. Analysis of Prevalence and Risk Factors of Adult Self-Reported Allergic Rhinitis and Asthma in Plain Lands and Hilly Areas of Shenmu City, China. Front Public Health. [online]. 2022. [cited 29 Mar 2022];9:749388. Available from: https://pubmed.ncbi.nlm.nih.gov/35059372/

Chang JC, Yang HY. Epidemiology of chronic kidney disease of undetermined aetiology in Taiwanese farmers: a cross-sectional study from Changhua Community-based Integrated Screening programme. Occup Environ Med. [online]. 2021. [cited 29 Mar 2022];78(12):849-858. Available from: https://pubmed.ncbi.nlm.nih.gov/34108255/

Pagán-Santana M, Amaya C, Rivera-Gutiérrez R, Caporali S. Chronic Diseases among Agricultural Workers in a Rural Area of Puerto Rico. J Agromedicine. [online]. 2021. [cited 29 Mar 2022];26(2):211-219. Available from: https://pubmed.ncbi.nlm.nih.gov/33143555/

Kitjakrancharoensin P, Yasan K, Hongyantarachai K, Ratanachokthorani K, Thammasarn J, Kuwuttiwai D et al. Prevalence and Risk Factors of Chronic Obstructive Pulmonary Disease Among Agriculturists in a Rural Community, Central Thailand. Int J Chron Obstruct Pulmon Dis. [online]. 2020. [cited 29 Mar 2022];15:2189-2198. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501975/

Hoang TT, Sikdar S, Xu CJ, Lee MK, Cardwell J, Forno E et al. Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study. Eur Respir J. [online]. 2020. [cited 29 Mar 2022];56(3): 2000217. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469973/

Patel S, Ram U, Ram F, Patel SK. Socioeconomic and demographic predictors of high blood pressure, diabetes, asthma and heart disease among adults engaged in various occupations: evidence from India. J Biosoc Sci. [online]. 2021. [cited 29 Mar 2022];52(5):629-649. Available from: https://pubmed.ncbi.nlm.nih.gov/31647045/

Soumagne T, Guillien A, Roche N, Annesi-Maesano I, Andujar P, Laurent L et al. In Patients with Mild-to-Moderate COPD, Tobacco Smoking, and Not COPD, Is Associated with a Higher Risk of Cardiovascular Comorbidity. Int J Chron Obstruct Pulmon Dis. [online]. 2020. [cited 29 Mar 2022];15: 1545-1555. Available from: https://pubmed.ncbi.nlm.nih.gov/32669840/

Jan S, Metten MA, Chapron A, Marette S, Robert AM, Guillot S et al. Use of the COPD Assessment Test (CAT) to screen for COPD in dairy farmers: AIRBAg study. Clin Respir J. [online]. 2020. [cited 29 Mar 2022] ;14(9):813-821. Available from: https://pubmed.ncbi.nlm.nih.gov/32386451/

Woldeamanuel, G.G., Mingude, A.B., Yitbarek, G.Y. et al. Chronic respiratory symptoms and pulmonary function status in Ethiopian agricultural workers: a comparative study. BMC Pulm Med. [online].2020. [cited 29 Mar 2022];20:86.Available from: https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-020-1120-3

Stoleski S, Minov J, Karadzinska-Bislimovska J, Mijakoski D, Atanasovska A, Bislimovska D. Work-related Asthma in Crop Farmers. Open Access Maced J Med Sci. [online]. 2020. [cited 29 Mar 2022]; 8(E):528-37. Available from: https://oamjms.eu/index.php/mjms/article/view/5255

Han J, Kim Y, Lee S, Lee SJ. Association between the prevalence of allergic reactions to skin prick tests and workplace types among agricultural workers in South Korea. Ann Occup Environ Med. [online]. 2020. [cited 29 Mar 2022]; 32:e36. Available from: https://pubmed.ncbi.nlm.nih.gov/34754457/

Saglan Y, Bilge U, Oztas D, Saglan R, Sarı YE, Balcıoglu H et al. The Prevalence of Asthma and Asthma-Like Symptoms among Seasonal Agricultural Workers. Biomed Res Int. [online]. 2020. [cited 29 Mar 2022]; 2020:3495272. Available from: https://pubmed.ncbi.nlm.nih.gov/32685471/

Suominen, Eetu N. MSc; Putus, Tuula MD. The Prevalence of Self-Reported Respiratory Symptoms and Related Diseases in Different Agricultural Sectors: Findings From a Cross-Sectional Survey in Finland. Journal of Occupational and Environmental Medicine. [online]. 2020. [cited 29 Mar 2022]; 62(1):9-12. Available from: https://journals.lww.com/joem/fulltext/2020/01000/the_prevalence_of_self_reported_respiratory.18.aspx

Liu S, Wolters PJ, Zhang Y, Zhao M, Liu D, Wang L et al. Association between greenhouse working exposure and bronchial asthma: A pilot, cross-sectional survey of 5,420 greenhouse farmers from northeast China. J Occup Environ Hyg. [online]. 2019. [cited 29 Mar 2022]; 16(4):286-293. Available from: https://pubmed.ncbi.nlm.nih.gov/30822226/

Saussereau J, Guillien A, Soumagne T, Laplante JJ, Laurent L, Bouhaddi M et al. Dietary Patterns and Prevalence of Post-bronchodilator Airway Obstruction in Dairy Farmers Exposed to Organic Dusts. COPD. [online]. 2019. [cited 29 Mar 2022]; 16(2):118-125. Available from: https://pubmed.ncbi.nlm.nih.gov/31298600/

Petarli GB, Cattafesta M, Sant'Anna MM, Bezerra OMPA, Zandonade E, Salaroli LB. Multimorbidity and complex multimorbidity in Brazilian rural workers. PLoS One. [online]. 2019. [cited 29 Mar 2022]; 14(11):e0225416. Available from: https://pubmed.ncbi.nlm.nih.gov/31743369/

Stoleski S, Minov J, Karadzinska-Bislimovska J, Mijakoski D, Atanasovska A, Bislimovska D. Asthma and Chronic Obstructive Pulmonary Disease Associated With Occupational Exposure in Dairy Farmers - Importance of Job Exposure Matrices. Open Access Maced J Med Sci. [online]. 2019. [cited 29 Mar 2022]; 7(14):2350-2359. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765081/

Jouneau S, Marette S, Robert AM, Gouyet T, Guillot S, Chapron A et al. Prevalence and risk factors of chronic obstructive pulmonary disease in dairy farmers: AIRBAg study. Environ Res. [online]. 2019. [cited 29 Mar 2022]; 169:1-6. Available from: https://pubmed.ncbi.nlm.nih.gov/30399467/

Ngajilo D, Singh T, Ratshikhopha E, Dayal P, Matuka O, Baatjies R et al. Risk factors associated with allergic sensitization and asthma phenotypes among poultry farm workers. Am J Ind Med. [online]. 2018. [cited 29 Mar 2022]; 61(6):515-523. Available from: https://pubmed.ncbi.nlm.nih.gov/29574825/

Rodríguez-Zamora MG, Zock JP, van Wendel de Joode B, Mora AM. Respiratory Health Outcomes, Rhinitis, and Eczema in Workers from Grain Storage Facilities in Costa Rica. Ann Work Expo Health. [online]. 2018. [cited 29 Mar 2022]; 62(9):1077-1086. Available from: https://pubmed.ncbi.nlm.nih.gov/30016387/

LeVan TD, Romberger DJ, Siahpush M, Grimm BL, Ramos AK, Johansson PL et al. Relationship of systemic IL-10 levels with proinflammatory cytokine responsiveness and lung function in agriculture workers. Respir Res. [online]. 2018. [cited 29 Mar 2022]; 19(1):166. Available from: https://pubmed.ncbi.nlm.nih.gov/30176916/

Aquart-Stewart A, Walters CA, White SA. The Impact of Tobacco and Occupational Exposure on Chronic Obstructive Pulmonary Disease in a 70 and over Jamaican Cohort from the Burden of Obstructive Lung Disease (Jamaica) Study. West Indian med. [online]. 2018. [cited 29 Mar 2022]; 67(spe): 458-464. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1045878

Stoleski S, Minov J, Karadzinska-Bislimovska J, Mijakoski D, Tutkun L. C-Reactive Protein Concentrations Among Crop and Dairy Farmers with Stable Chronic Obstructive Pulmonary Disease. Open Access Maced J Med Sci. [online]. 2017. [cited 29 Mar 2022]; 5(6):724-729. Available from: https://pubmed.ncbi.nlm.nih.gov/29104680/

Moghtaderi M, Torab Jahromi M, Farjadian S, Ghassemi P, Hosseini Teshnizi S. Decreased Sensitization to Aeroallergens among Southwestern Iranian Male Farmers. Iran J Allergy Asthma Immunol. [online]. 2017. [cited 29 Mar 2022]; 16(4):307-312. Available from: https://pubmed.ncbi.nlm.nih.gov/28865410/

LeVan TD, Smith LM, Heires AJ, Mikuls TR, Meza JL, Weissenburger-Moser LA et al. Interaction of CD14 haplotypes and soluble CD14 on pulmonary function in agricultural workers. Respir Res. [online]. 2017. [cited 29 Mar 2022]; 18(1):49. Available from: https://pubmed.ncbi.nlm.nih.gov/28302109/

Weissenburger-Moser L, Meza J, Yu F, Shiyanbola O, Romberger DJ, LeVan TD. A principal factor analysis to characterize agricultural exposures among Nebraska veterans. J Expo Sci Environ Epidemiol. [online]. 2017. [cited 29 Mar 2022]; 27(2):214-220. Available from: https://pubmed.ncbi.nlm.nih.gov/27049536/

Muñoz-Quezada MT, Lucero B, Iglesias V, Levy K, Muñoz MP, Achú E et al. Exposure to organophosphate (OP) pesticides and health conditions in agricultural and non-agricultural workers from Maule, Chile. Int J Environ Health Res. [online]. 2017. [cited 29 Mar 2022]; 27(1):82-93. Available from: https://pubmed.ncbi.nlm.nih.gov/28002976/

Guillien A, Puyraveau M, Soumagne T, Guillot S, Rannou F, Marquette D et al. Prevalence and risk factors for COPD in farmers: a cross-sectional controlled study. Eur Respir J. [online]. 2016. [cited 29 Mar 2022]; 47(1):95-103. Available from: https://pubmed.ncbi.nlm.nih.gov/26453630/

Cushen B, Sulaiman I, Donoghue N, Langan D, Cahill T, Nic Dhonncha E et al. High prevalence of obstructive lung disease in non-smoking farmers: The Irish farmers lung health study. Respir Med. [online]. 2016. [cited 29 Mar 2022]; 115:13-9. Available from: https://pubmed.ncbi.nlm.nih.gov/27215498/

Akpinar-Elci M, Pasquale DK, Abrokwah M, Nguyen M, Elci OC. United Airway Disease Among Crop Farmers. J Agromedicine. [online]. 2016. [cited 29 Mar 2022];21(3):217-23. Available from: https://pubmed.ncbi.nlm.nih.gov/27088572/

Liu S, Ren Y, Wen D, Chen Y, Chen D, Li L et al. Prevalence and risk factors for COPD in greenhouse farmers: a large, cross-sectional survey of 5,880 farmers from northeast China. Int J Chron Obstruct Pulmon Dis. [online]. 2015. [cited 29 Mar 2022]; 10:2097-108. Available from: https://pubmed.ncbi.nlm.nih.gov/26491280/

Stoecklin-Marois MT, Bigham CW, Bennett D, Tancredi DJ, Schenker MB. Occupational exposures and migration factors associated with respiratory health in California Latino farm workers: the MICASA study. J Occup Environ Med. [online]. 2015. [cited 29 Mar 2022]; 57(2):152-8. Available from: https://pubmed.ncbi.nlm.nih.gov/25654515/

Eduard W, Schlünssen V, Sigsgaard T, Omland Ø, Pearce N, Douwes J. Can selection explain the protective effects of farming on asthma? Ann Agric Environ Med. [online]. 2015. [cited 29 Mar 2022]; 22(3):467-9. Available from: https://pubmed.ncbi.nlm.nih.gov/26403116/

Jouneau S, Pinault M, Gouyet T, Brinchault G, Guillot S, Viel JF et al. Étude AIRBAg : résultats préliminaires après un an de dépistage de la BPCO agricole [AIRBAg study: preliminary results after one year of screening for COPD in dairy farmers]. Rev Mal Respir. [online]. 2015. [cited 29 Mar 2022];32(3):240-8. Available from: https://pubmed.ncbi.nlm.nih.gov/25847201/

Stoleski S, Minov J, Karadzinska-Bislimovska J, Mijakoski D. Chronic obstructive pulmonary disease in never-smoking dairy farmers. Open Respir Med J. [online]. 2015. [cited 29 Mar 2022]; 9:59-66. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397828/

Ndlovu V, Dalvie MA, Jeebhay MF. Asthma associated with pesticide exposure among women in rural Western Cape of South Africa. Am J Ind Med. [online]. 2014. [cited 29 Mar 2022]; 57(12):1331-43. Available from: https://pubmed.ncbi.nlm.nih.gov/25348901/

Kearney GD, Chatterjee AB, Talton J, Chen H, Quandt SA, Summers P et al. The association of respiratory symptoms and indoor housing conditions among migrant farmworkers in eastern North Carolina. J Agromedicine. [online]. 2014. [cited 29 Mar 2022]; 19(4):395-405. Available from: https://pubmed.ncbi.nlm.nih.gov/25275405/

Smit LA, Strachan DP, Vermeulen R, de Bakker PI, Demenais F, Dumas O et al. Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role? Eur Respir J. [online]. 2014. [cited 29 Mar 2022]; 44(5):1234-42. Available from: https://pubmed.ncbi.nlm.nih.gov/25034568/

Tual S, Clin B, Levêque-Morlais N, Raherison C, Baldi I, Lebailly P. Agricultural exposures and chronic bronchitis: findings from the AGRICAN (AGRIculture and CANcer) cohort. Ann Epidemiol. [online]. 2013. [cited 29 Mar 2022]; 23(9):539-45. Available from: https://pubmed.ncbi.nlm.nih.gov/23886973/

Ghosh RE, Cullinan P, Fishwick D, Hoyle J, Warburton CJ, Strachan DP et al. Asthma and occupation in the 1958 birth cohort. Thorax. [online]. 2013. [cited 29 Mar 2022]; 68(4):365-71. Available from: https://pubmed.ncbi.nlm.nih.gov/23339164/

Guillam MT, Pédrono G, Le Bouquin S, Huneau A, Gaudon J, Leborgne R et al. Chronic respiratory symptoms of poultry farmers and model-based estimates of long-term dust exposure. Ann Agric Environ Med. [online]. 2013. [cited 29 Mar 2022]; 20(2):307-11. Available from: https://pubmed.ncbi.nlm.nih.gov/23772582/

Viegas S, Faísca VM, Dias H, Clérigo A, Carolino E, Viegas C. Occupational exposure to poultry dust and effects on the respiratory system in workers. J Toxicol Environ Health A. [online]. 2013. [cited 29 Mar 2022]; 76(4-5):230-9. Available from: https://pubmed.ncbi.nlm.nih.gov/23514065/

Viegas S, Mateus V, Almeida-Silva M, Carolino E, Viegas C. Occupational exposure to particulate matter and respiratory symptoms in Portuguese swine barn workers. J Toxicol Environ Health A. [online]. 2013. [cited 29 Mar 2022]; 76(17):1007-14. Available from: https://pubmed.ncbi.nlm.nih.gov/24168036/

Sabino R, Faísca VM, Carolino E, Veríssimo C, Viegas C. Occupational exposure to Aspergillus by swine and poultry farm workers in Portugal. J Toxicol Environ Health A. [online]. 2012. [cited 29 Mar 2022]; 75(22-23):1381-91. Available from: https://pubmed.ncbi.nlm.nih.gov/23095156/

Jouneau S, Boché A, Brinchault G, Fekete K, Guillot S, Bayat S et al. On-site screening of farming-induced chronic obstructive pulmonary disease with the use of an electronic mini-spirometer: results of a pilot study in Brittany, France. Int Arch Occup Environ Health. [online]. 2012. [cited 29 Mar 2022]; 85(6):623-30. Available from: https://pubmed.ncbi.nlm.nih.gov/21986906/

Cha ES, Lee YK, Moon EK, Kim YB, Lee YJ, Jeong WC et al. Paraquat application and respiratory health effects among South Korean farmers. Occup Environ Med. [online]. 2012. [cited 29 Mar 2022]; 69(6):398-403. Available from: https://pubmed.ncbi.nlm.nih.gov/22213838/

Mounchetrou IN, Monnet E, Laplante JJ, Dalphin JC, Thaon I. Predictors of early cessation of dairy farming in the French Doubs province: 12-year follow-up. Am J Ind Med. [online]. 2012. [cited 29 Mar 2022];55(2):136-42. Available from: https://pubmed.ncbi.nlm.nih.gov/22069061/

Ding YP, Yao HX, Tang XL, He HW, Shi HF, Lin L et al. An epidemiology study of bronchial asthma in the Li ethnic group in China. Asian Pac J Trop Med. [online]. 2012. [cited 29 Mar 2022]; 5(2):157-61. Available from: https://pubmed.ncbi.nlm.nih.gov/22221762/

Rask-Andersen A. Asthma increase among farmers: a 12-year follow-up. Ups J Med Sci. [online]. 2011. [cited 29 Mar 2022]; 116(1):60-71. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039762/

I. Thaon, A. Thiebaut, L. Jochault, A. Lefebvre, J.J. Laplante, J.C. Dalphin. Influence of hay and animal feed exposure on respiratory status: a longitudinal study. European Respiratory Journal. [online]. 2011. [cited 29 Mar 2022]; 37 (4) :767-774. Available from: https://erj.ersjournals.com/content/37/4/767

Mazurek JM, Schleiff PL. Physician recognition of work-related asthma among US farm operators. Fam Med. [online]. 2010. [cited 29 Mar 2022]; 42(6):408-13. Available from: https://pubmed.ncbi.nlm.nih.gov/20526908/

Eng A, 'T Mannetje A, Douwes J, Cheng S, McLean D, Ellison-Loschmann L et al. The New Zealand workforce survey II: occupational risk factors for asthma. Ann Occup Hyg. [online]. 2010. [cited 29 Mar 2022]; 54(2):154-64. Available from: https://pubmed.ncbi.nlm.nih.gov/20080813/

Patiwael JA, Jong NW, Burdorf A, Groot H, Gerth van Wijk R. Occupational allergy to bell pepper pollen in greenhouses in the Netherlands, an 8-year follow-up study. Allergy. [online]. 2010. [cited 29 Mar 2022]; 65(11):1423-9. Available from: https://pubmed.ncbi.nlm.nih.gov/20584006/

Eduard W, Pearce N, Douwes J. Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents. Chest. [online]. 2009. [cited 29 Mar 2022]; 136(3):716-725. Available from: https://pubmed.ncbi.nlm.nih.gov/19318669/

Hoppin JA, Umbach DM, London SJ, Henneberger PK, Kullman GJ, Coble J et al. esticide use and adult-onset asthma among male farmers in the Agricultural Health Study. Eur Respir J. [online]. 2009. [cited 29 Mar 2022]; 34(6):1296-303. Available from: https://pubmed.ncbi.nlm.nih.gov/19541724/

Chakraborty S, Mukherjee S, Roychoudhury S, Siddique S, Lahiri T, Ray MR. Chronic exposures to cholinesterase-inhibiting pesticides adversely affect respiratory health of agricultural workers in India. J Occup Health. [online]. 2009. [cited 29 Mar 2022]; 51(6):488-97. Available from: https://pubmed.ncbi.nlm.nih.gov/19851039/

Dosman JA, Chenard L, Rennie DC, Senthilselvan A. Reciprocal association between atopy and respiratory symptoms in fully employed female, but not male, workers in swine operations. J Agromedicine. [online]. 2009. [cited 29 Mar 2022]; 14(2):270-6. Available from: https://pubmed.ncbi.nlm.nih.gov/19437288/

Fieten KB, Kromhout H, Heederik D, van Wendel de Joode B. Pesticide exposure and respiratory health of indigenous women in Costa Rica. Am J Epidemiol. [online]. 2009. [cited 29 Mar 2022]; 169(12):1500-6. Available from: https://pubmed.ncbi.nlm.nih.gov/19372212/

Hoppin JA, Umbach DM, London SJ, Henneberger PK, Kullman GJ, Alavanja MC et al. Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study. Am J Respir Crit Care Med. [online]. 2008. [cited 29 Mar 2022]; 177(1):11-8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176117/

Seo T, Pahwa P, McDuffie HH, Yurube K, Egoshi M, Umemoto Y et al. Association between cytochrome P450 3A5 polymorphism and the lung function in Saskatchewan grain workers. Pharmacogenet Genomics. [online]. 2008. [cited 29 Mar 2022]; 18(6):487-93. Available from: https://pubmed.ncbi.nlm.nih.gov/18496128/

Sigurdarson ST, Gudmundsson G, Sigurvinsdottir L, Kline JN, Tomasson K. Respiratory disorders are not more common in farmers. Results from a study on Icelandic animal farmers. Respir Med. [online]. 2008. [cited 29 Mar 2022]; 102(12):1839-43. Available from: https://pubmed.ncbi.nlm.nih.gov/18715772/

Smit LA, Heederik D, Doekes G, Blom C, van Zweden I, Wouters IM. Exposure-response analysis of allergy and respiratory symptoms in endotoxin-exposed adults. Eur Respir J. [online]. 2008. [cited 29 Mar 2022]; 31(6):1241-8. Available from: https://pubmed.ncbi.nlm.nih.gov/18256063/

Boers D, van Amelsvoort L, Colosio C, Corsini E, Fustinoni S, Campo L et al. Asthmatic symptoms after exposure to ethylenebisdithiocarbamates and other pesticides in the Europit field studies. Hum Exp Toxicol. [online]. 2008. [cited 29 Mar 2022]; 27(9):721-7. Available from: https://pubmed.ncbi.nlm.nih.gov/19042955/

Valcin M, Henneberger PK, Kullman GJ, Umbach DM, London SJ, Alavanja MC et al. Chronic bronchitis among nonsmoking farm women in the agricultural health study. J Occup Environ Med. [online]. 2007. [cited 29 Mar 2022]; 49(5):574-83. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074236/

Hoppin JA, Valcin M, Henneberger PK, Kullman GJ, Umbach DM, London SJ et al. Pesticide use and chronic bronchitis among farmers in the Agricultural Health Study. Am J Ind Med. [online]. 2007. [cited 29 Mar 2022]; 50(12):969-79. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806052/

Smit LA, Bongers SI, Ruven HJ, Rijkers GT, Wouters IM, Heederik D et al. Atopy and new-onset asthma in young Danish farmers and CD14, TLR2, and TLR4 genetic polymorphisms: a nested case-control study. Clin Exp Allergy. [online]. 2007. [cited 29 Mar 2022]; 37(11):1602-8. Available from: https://pubmed.ncbi.nlm.nih.gov/17877764/

Lamprecht B, Schirnhofer L, Kaiser B, Studnicka M, Buist AS. Farming and the prevalence of non-reversible airways obstruction: results from a population-based study. Am J Ind Med. [online]. 2007. [cited 29 Mar 2022]; 50(6):421-6. Available from: https://pubmed.ncbi.nlm.nih.gov/17497693/

Douwes J, Travier N, Huang K, Cheng S, McKenzie J, Le Gros G et al. Lifelong farm exposure may strongly reduce the risk of asthma in adults. Allergy. [online]. 2007. [cited 29 Mar 2022]; 62(10):1158-65. Available from: https://pubmed.ncbi.nlm.nih.gov/17845585/

Chen Y, Rennie D, Cormier Y, McDuffie H, Pahwa P, Dosman J. Reduced risk of atopic sensitization among farmers: the Humboldt study. Int Arch Allergy Immunol. [online]. 2007. [cited 29 Mar 2022]; 144(4):338-42. Available from: https://pubmed.ncbi.nlm.nih.gov/17664888/

Senthilselvan A, Chénard L, Ulmer K, Gibson-Burlinguette N, Leuschen C, Dosman JA. Excess respiratory symptoms in full-time male and female workers in large-scale swine operations. Chest. [online]. 2007. [cited 29 Mar 2022]; 131(4):1197-204. Available from: https://pubmed.ncbi.nlm.nih.gov/17426228/

Jeebhay MF, Baatjies R, Chang YS, Kim YK, Kim YY, Major V et al. Risk factors for allergy due to the two-spotted spider mite (Tetranychus urticae) among table grape farm workers. Int Arch Allergy Immunol. [online]. 2007. [cited 29 Mar 2022]; 144(2):143-9. Available from: https://pubmed.ncbi.nlm.nih.gov/17536223/

Smit LA, Zuurbier M, Doekes G, Wouters IM, Heederik D, Douwes J. Hay fever and asthma symptoms in conventional and organic farmers in The Netherlands. Occup Environ Med. [online]. 2007. [cited 29 Mar 2022]; 64(2):101-7. Available from: https://pubmed.ncbi.nlm.nih.gov/17018582/

Hashemi N, Mirsadraee M, Shakeri MT, Varasteh AR. Prevalence of work-related respiratory symptoms in Iranian farmers. Can Respir J. [online]. 2006. [cited 29 Mar 2022]; 13(4):198-202. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683279/

Faria NM, Facchini LA, Fassa AG, Tomasi E. Trabalho rural, exposição a poeiras e sintomas respiratórios entre agricultores [Farm work, dust exposure and respiratory symptoms among farmers]. Rev Saude Publica. [online]. 2006. [cited 29 Mar 2022]; 40(5):827-36. Available from: https://pubmed.ncbi.nlm.nih.gov/17301904/

Hoppin JA, Umbach DM, London SJ, Lynch CF, Alavanja MC, Sandler DP. Pesticides and adult respiratory outcomes in the agricultural health study. Ann N Y Acad Sci. [online]. 2006. [cited 29 Mar 2022]; 1076:343-54. Available from: https://pubmed.ncbi.nlm.nih.gov/17119214/

Schenker MB, Farrar JA, Mitchell DC, Green RS, Samuels SJ, Lawson RJ et al. Agricultural dust exposure and respiratory symptoms among California farm operators. J Occup Environ Med. [online]. 2005. [cited 29 Mar 2022]; 47(11):1157-66. Available from: https://pubmed.ncbi.nlm.nih.gov/16282877/

Arif AA, Rohrer JE, Delclos GL. A population-based study of asthma, quality of life, and occupation among elderly Hispanic and non-Hispanic whites: a cross-sectional investigation. BMC Public Health. [online]. 2005. [cited 29 Mar 2022]; 5:97. Available from: https://pubmed.ncbi.nlm.nih.gov/16176583/

Jenkins PL, Earle-Richardson G, Bell EM, May JJ, Green A. Chronic disease risk in central New York dairy farmers: results from a large health survey 1989-1999. Am J Ind Med. [online]. 2005. [cited 29 Mar 2022]; 47(1):20-6. Available from: https://pubmed.ncbi.nlm.nih.gov/15597357/

Chatzi L, Prokopakis E, Tzanakis N, Alegakis A, Bizakis I, Siafakas N et al. Allergic rhinitis, asthma, and atopy among grape farmers in a rural population in Crete, Greece. Chest. [online]. 2005. [cited 29 Mar 2022]; 127(1):372-8. Available from: https://pubmed.ncbi.nlm.nih.gov/15654002/

Lambert GP, Spurzem JR, Romberger DJ, Wyatt TA, Lyden E, Stromquist AM et al. Tumor necrosis factor-alpha hyper-responsiveness to endotoxin in whole blood is associated with chronic bronchitis in farmers. J Agromedicine. [online]. 2005. [cited 29 Mar 2022]; 10(1):39-44. Available from: https://pubmed.ncbi.nlm.nih.gov/15927916/

Faria NM, Facchini LA, Fassa AG, Tomasi E. Pesticides and respiratory symptoms among farmers. Rev Saude Publica. [online]. 2005. [cited 29 Mar 2022]; 39(6):973-81. Available from: https://pubmed.ncbi.nlm.nih.gov/16341409/

Monsó E, Riu E, Radon K, Magarolas R, Danuser B, Iversen M et al. Chronic obstructive pulmonary disease in never-smoking animal farmers working inside confinement buildings. Am J Ind Med. [online]. 2004. [cited 29 Mar 2022]; 46(4):357-62. Available from: https://pubmed.ncbi.nlm.nih.gov/15376214/

Eduard W, Omenaas E, Bakke PS, Douwes J, Heederik D. Atopic and non-atopic asthma in a farming and a general population. Am J Ind Med. [online]. 2004. [cited 29 Mar 2022]; 46(4):396-9. Available from: https://pubmed.ncbi.nlm.nih.gov/15376208/

Lembke B, Janson C, Norbäck D, Rask-Andersen A. High risk of adult-onset asthma and work-related wheeze in farmers despite low prevalence of asthma in young farmers. Int J Tuberc Lung Dis. [online]. 2004. [cited 29 Mar 2022]; 8(11):1285-91. Available from: https://pubmed.ncbi.nlm.nih.gov/15581194/

Walusiak J, Krawczyk-Adamus P, Hanke W, Wittczak T, Pałczyński C. Small nonspecialized farming as a protective factor against immediate-type occupational respiratory allergy? Allergy. [online]. 2004. [cited 29 Mar 2022]; 59(12):1294-300. Available from: https://pubmed.ncbi.nlm.nih.gov/15507098/

Hoppin JA, Umbach DM, London SJ, Alavanja MC, Sandler DP. Diesel exhaust, solvents, and other occupational exposures as risk factors for wheeze among farmers. Am J Respir Crit Care Med. [online]. 2004. [cited 29 Mar 2022]; 169(12):1308-13. Available from: https://pubmed.ncbi.nlm.nih.gov/15070818/

Hoppin JA, Umbach DM, London SJ, Alavanja MC, Sandler DP. Animal production and wheeze in the Agricultural Health Study: interactions with atopy, asthma, and smoking. Occup Environ Med. [online]. 2003. [cited 29 Mar 2022]; 60(8):e3. Available from: https://pubmed.ncbi.nlm.nih.gov/12883030/

Chaudemanche H, Monnet E, Westeel V, Pernet D, Dubiez A, Perrin C et al. Respiratory status in dairy farmers in France; cross sectional and longitudinal analyses. Occup Environ Med. [online]. 2003. [cited 29 Mar 2022]; 60(11):858-63. Available from: https://pubmed.ncbi.nlm.nih.gov/14573716/

Monsó E, Schenker M, Radon K, Riu E, Magarolas R, McCurdy S et al. Region-related risk factors for respiratory symptoms in European and Californian farmers. Eur Respir J. [online]. 2003. [cited 29 Mar 2022]; 21(2):323-31. Available from: https://pubmed.ncbi.nlm.nih.gov/12608449/

Radon K, Winter C. Prevalence of respiratory symptoms in sheep breeders. Occupational and Environmental Medicine. [online]. 2003. [cited 29 Mar 2022]; 60:770-773. Available from: https://oem.bmj.com/content/60/10/770

Radon K, Garz S, Riess A, Koops F, Monso E, Weber C et al. European Farmers' Project. Atemwegs- und Lungenerkrankungen in der Europäischen Landwirtschaft - Teil 2: Ergebnisse der europäischen Landwirtschaftsstudie - [Respiratory diseases in European farmers-II. Part of the European farmers' project]. Pneumologie. [online]. 2003. [cited 29 Mar 2022]; 57(9):510-7. Available from: https://pubmed.ncbi.nlm.nih.gov/13680471/

Koskela HO, Iivanainen KK, Remes ST, Pekkanen J. Pet- and pollen-induced upper airway symptoms in farmers and in nonfarmers. Eur Respir J. [online]. 2003. [cited 29 Mar 2022]; 22(1):135-40. Available from: https://pubmed.ncbi.nlm.nih.gov/12882463/

Hnizdo E, Sullivan PA, Bang KM, Wagner G. Association between chronic obstructive pulmonary disease and employment by industry and occupation in the US population: a study of data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol. [online]. 2002. [cited 29 Mar 2022]; 156(8):738-46. Available from: https://pubmed.ncbi.nlm.nih.gov/12370162/

Claudia Borghetti, Ramón Magarolas, Isabel Badorrey, Katja Radon, Josep Morera, Eduard Monsó. Sensibilización y asma ocupacional en los avicultores. Medicina Clínica. [online]. 2002. [cited 29 Mar 2022]; 118(7): 251-255. Available from: https://www.sciencedirect.com/science/article/abs/pii/S002577530272352X

Monsó E, Magarolas R, Badorrey I, Radon K, Nowak D, Morera J. Occupational asthma in greenhouse flower and ornamental plant growers. Am J Respir Crit Care Med. [online]. 2002. [cited 29 Mar 2022]; 165(7):954-60. Available from: https://pubmed.ncbi.nlm.nih.gov/11934721/

van Hage-Hamsten M, Johansson E, Kronqvist M, Loughry A, Cookson WO, Moffatt MF. Associations of Fc epsilon R1-beta polymorphisms with immunoglobin E antibody responses to common inhalant allergens in a rural population. Clin Exp Allergy. [online]. 2002. [cited 29 Mar 2022]; 32(6):838-42. Available from: https://pubmed.ncbi.nlm.nih.gov/12047428/

Merchant JA, Stromquist AM, Kelly KM, Zwerling C, Reynolds SJ, Burmeister LF. Chronic disease and injury in an agricultural county: The Keokuk County Rural Health Cohort Study. J Rural Health. [online]. 2002. [cited 29 Mar 2022]; 18(4):521-35. Available from: https://pubmed.ncbi.nlm.nih.gov/12380895/

Mustajbegovic J, Zuskin E, Schachter EN, Kern J, Vrcic-Keglevic M, Vitale K et al. Respiratory findings in livestock farmworkers. J Occup Environ Med. [online]. 2001. [cited 29 Mar 2022]; 43(6):576-84. Available from: https://pubmed.ncbi.nlm.nih.gov/11411331/

Danuser B, Weber C, Künzli N, Schindler C, Nowak D. Respiratory symptoms in Swiss farmers: an epidemiological study of risk factors. Am J Ind Med. [online]. 2001. [cited 29 Mar 2022]; 39(4):410-8. Available from: https://pubmed.ncbi.nlm.nih.gov/11323791/

Radon K, Danuser B, Iversen M, Jörres R, Monso E, Opravil U et al. Respiratory symptoms in European animal farmers. Eur Respir J. [online]. 2001. [cited 29 Mar 2022]; 17(4):747-54. Available from: https://pubmed.ncbi.nlm.nih.gov/11401073/

Astarita C, Gargano D, Manguso F, Romano C, Montanaro D, Pezzuto F et al. Epidemiology of allergic occupational diseases induced by Tetranychus urticae in greenhouse and open-field farmers living in a temperate climate area. Allergy. [online]. 2001. [cited 29 Mar 2022]; 56(12):1157-63. Available from: https://pubmed.ncbi.nlm.nih.gov/11736744/

Kimbell-Dunn MR, Fishwick RD, Bradshaw L, Erkinjuntti-Pekkanen R, Pearce N. Work-related respiratory symptoms in New Zealand farmers. Am J Ind Med. [online]. 2001. [cited 29 Mar 2022]; 39(3):292-300. Available from: https://pubmed.ncbi.nlm.nih.gov/11241562/

Monsó E, Magarolas R, Radon K, Danuser B, Iversen M, Weber C et al. Respiratory symptoms of obstructive lung disease in European crop farmers. Am J Respir Crit Care Med. [online]. 2000. [cited 29 Mar 2022]; 162(4 Pt 1):1246-50. Available from: https://pubmed.ncbi.nlm.nih.gov/11029325/

Karjalainen A, Kurppa K, Virtanen S, Keskinen H, Nordman H. Incidence of occupational asthma by occupation and industry in Finland. Am J Ind Med. [online]. 2000. [cited 29 Mar 2022]; 37(5):451-8. Available from: https://pubmed.ncbi.nlm.nih.gov/10723039/

Park HS, Kim HY, Kim YK, Son JW, Nahm DH, Cho SH et al. Specific IgG1 and IgG4 antibodies to citrus red mite in citrus farmers: a study of their relationship to respiratory symptoms. J Korean Med Sci. [online]. 2000. [cited 29 Mar 2022]; 15(4):407-12. Available from: https://pubmed.ncbi.nlm.nih.gov/10983688/

Ciesielski S, Loomis DP, Mims SR, Auer A. Pesticide exposures, cholinesterase depression, and symptoms among North Carolina migrant farmworkers. Am J Public Health. [online]. 1994. [cited 29 Mar 2022]; 84(3):446-51. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1614838/

Ramon Magarolas, Eduard Monsó, Xavier Aguilar, Katja Radon, Dennis Nowak, Carlos Martínez et al. Prevalencia y factores de riesgo de síntomas respiratorios en la agricultura y la ganadería. Medicina Clínica. [online]. 2000. [cited 29 Mar 2022]; 114(18): 685-689. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0025775300714035

Vogelzang PF, van der Gulden JW, Tielen MJ, Folgering H, van Schayck CP. Health-based selection for asthma, but not for chronic bronchitis, in pig farmers: an evidence-based hypothesis. Eur Respir J. [online]. 1999. [cited 29 Mar 2022]; 13(1):187-9. Available from: https://pubmed.ncbi.nlm.nih.gov/10836346/

Bener A, Lestringant GG, Beshwari MM, Pasha MA. Respiratory symptoms, skin disorders and serum IgE levels in farm workers. Allerg Immunol (Paris). [online]. 1999. [cited 29 Mar 2022]; 31(2):52-6. Available from: https://pubmed.ncbi.nlm.nih.gov/10219428/

Kim YK, Son JW, Kim HY, Park HS, Lee MH, Cho SH et al. Citrus red mite (Panonychus citri) is the most common sensitizing allergen of asthma and rhinitis in citrus farmers. Clin Exp Allergy. [online]. 1999. [cited 29 Mar 2022]; 29(8):1102-9. Available from: https://pubmed.ncbi.nlm.nih.gov/10457115/

KRONQVIST, JOHANSSON, PERSHAGEN, JOHANSSON, VAN HAGE-HAMSTEN. Increasing prevalence of asthma over 12 years among dairy farmers on Gotland, Sweden: storage mites remain dominant allergens. Clinical & Experimental Allergy. [online]. 1999. [cited 29 Mar 2022]; 29: 35-41. Available from: https://onlinelibrary.wiley.com/doi/10.1046/j.1365-2222.1999.00452.x

Beshwari M. M. M., Bener A, Ameen A, Al-Mehdi A.M., Ouda H. Z., Pasha M. A. H. Pesticide-related health problems and diseases among farmers in the United Arab Emirates. International Journal of Environmental Health Research. [online]. 1999. [cited 29 Mar 2022]; 9(3): 213–221. Available from: https://www.tandfonline.com/doi/abs/10.1080/09603129973182

Dalphin JC, Dubiez A, Monnet E, Gora D, Westeel V, Pernet D et al. Prevalence of asthma and respiratory symptoms in dairy farmers in the French province of the Doubs. Am J Respir Crit Care Med. [online]. 1998. [cited 29 Mar 2022]; 158(5 Pt 1):1493-8. Available from: https://pubmed.ncbi.nlm.nih.gov/9817698/

Rees D, Nelson G, Kielkowski D, Wasserfall C, da Costa A. Respiratory health and immunological profile of poultry workers. S Afr Med J. [online]. 1998. [cited 29 Mar 2022]; 88(9):1110-7. Available from: https://pubmed.ncbi.nlm.nih.gov/9798499/

Melbostad E, Eduard W, Magnus P. Chronic bronchitis in farmers. Scand J Work Environ Health. [online]. 1997. [cited 29 Mar 2022]; 23(4):271-80. Available from: https://pubmed.ncbi.nlm.nih.gov/9322818/

Mauny F, Polio JC, Monnet E, Pernet D, Laplante JJ, Depierre A et al. Longitudinal study of respiratory health in dairy farmers: influence of artificial barn fodder drying. Eur Respir J. [online]. 1997. [cited 29 Mar 2022]; 10(11):2522-8. Available from: https://pubmed.ncbi.nlm.nih.gov/9426089/

Nejjari C, Tessier JF, Letenneur L, Dartigues JF, Barberger-Gateau P, Salamon R. Prevalence of self-reported asthma symptoms in a French elderly sample. Respir Med. [online]. 1996. [cited 29 Mar 2022]; 90(7):401-8. Available from: https://pubmed.ncbi.nlm.nih.gov/8796232/

McCurdy SA, Ferguson TJ, Goldsmith DF, Parker JE, Schenker MB. Respiratory health of California rice farmers. Am J Respir Crit Care Med. [online]. 1996. [cited 29 Mar 2022]; 153(5):1553-9. Available from: https://pubmed.ncbi.nlm.nih.gov/8630601/

Zuskin E, Mustajbegovic J, Schachter EN, Kern J, Rienzi N, Goswami S et al. Respiratory function in poultry workers and pharmacologic characterization of poultry dust extract. Environ Res. [online]. 1995. [cited 29 Mar 2022]; 70(1):11-9. Available from: https://pubmed.ncbi.nlm.nih.gov/8603653/

Dalphin JC, Polio JC, Pernet D, Maheu MF, Toson B, Dubiez A et al. Influence of barn drying of fodder on respiratory symptoms and function in dairy farmers of the Doubs region of France. Thorax. [online]. 1994. [cited 29 Mar 2022]; 49(1):50-3. Available from: https://pubmed.ncbi.nlm.nih.gov/8153940/

Jean C.H. Dalphin, Didier Pernet, Andre Dubiez, Didier Debieuvre, Hubert Allemand, Alain Depierre. Etiologic Factors of Chronic Bronchitis in Dairy Farmers: Case Control Study in the Doubs Region of France. Chest. [online]. 1993. [cited 29 Mar 2022]; 103(2): 417-421. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0012369215414564

Senthilselvan A, Chen Y, Dosman JA. Predictors of asthma and wheezing in adults. Grain farming, sex, and smoking. Am Rev Respir Dis. [online]. 1993. [cited 29 Mar 2022]; 148(3):667-70. Available from: https://pubmed.ncbi.nlm.nih.gov/8368638/

Zejda JE, Hurst TS, Rhodes CS, Barber EM, McDuffie HH, Dosman JA. Respiratory health of swine producers. Focus on young workers. Chest. [online]. 1993. [cited 29 Mar 2022]; 103(3):702-9. Available from: https://pubmed.ncbi.nlm.nih.gov/8449055/

Senthilselvan A, McDuffie HH, Dosman JA. Association of asthma with use of pesticides. Results of a cross-sectional survey of farmers. Am Rev Respir Dis. [online]. 1992. [cited 29 Mar 2022]; 146(4):884-7. Available from: https://pubmed.ncbi.nlm.nih.gov/1416414/

Chen Y, Horne SL, McDuffie HH, Dosman JA. Combined effect of grain farming and smoking on lung function and the prevalence of chronic bronchitis. Int J Epidemiol. [online]. 1991. [cited 29 Mar 2022]; 20(2):416-23. Available from: https://pubmed.ncbi.nlm.nih.gov/1917244/

Iversen M, Pedersen B. The prevalence of allergy in Danish farmers. Allergy. [online]. 1990. [cited 29 Mar 2022]; 45(5):347-53. Available from: https://pubmed.ncbi.nlm.nih.gov/2378438/

Li DH, Yuan L, Yi SL, Jiang ZH. Effects of wood dust exposure on respiratory health: cross-sectional study among farmers exposed to wood dust. Am J Ind Med. [online]. 1990. [cited 29 Mar 2022]; 17(1):84-5. Available from: https://pubmed.ncbi.nlm.nih.gov/2305801/

Dalphin JC, Bildstein F, Pernet D, Dubiez A, Depierre A. Prevalence of chronic bronchitis and respiratory function in a group of dairy farmers in the French Doubs province. Chest. [online]. 1989. [cited 29 Mar 2022]; 95(6):1244-7. Available from: https://pubmed.ncbi.nlm.nih.gov/2721258/

Terho EO, Husman K, Vohlonen I, Heinonen OP. Atopy, smoking, and chronic bronchitis. J Epidemiol Community Health. [online]. 1987. [cited 29 Mar 2022]; 41(4):300-5. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1052651/

van Hage-Hamsten M, Johansson SG, Zetterström O. Predominance of mite allergy over allergy to pollens and animal danders in a farming population. Clin Allergy. [online]. 1987. [cited 29 Mar 2022]; 17(5):417-23. Available from: https://pubmed.ncbi.nlm.nih.gov/3499998/

Marcer G, Simioni L, Saia B, Saladino G, Gemignani C, Mastrangelo G. Study of immunological parameters in farmer's lung. Clin Allergy. [online]. 1983. [cited 29 Mar 2022]; 13(5):443-9. Available from: https://pubmed.ncbi.nlm.nih.gov/6605219/