Development of Vaginal Tablets from Thai Herb Extracts for Candidiasis
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Abstract
The objectives of this study to formulate and evaluate vaginal tablets from Thai medicinal herbs to treat vulvoginal candidiasis and meet the requirements of United States Pharmacopeia 35/National formulary 30 (USP35/NF30). Screening 6 Thai medicinal herbs that there has a long history of folk medicine demonstrates the effect for anticandidal activity such as garlic, ginger, galangal, champoo ginger, cassumunar ginger and java ginger in single and combine two extracts (1:1). The mixture of garlic and galangal ethanol extracts had the strong inhibition zone and great minimal inhibitory concentration. Six vaginal tablets formulations were prepared using wet granulation and then weight variation, thickness, hardness, friability, and dissolution were evaluated based on the USP35/NF30. Formulation consisting of microcrystalline cellulose PH102 and lactose as a diluent and acacia as a binder suite for in vaginal tablet. Therefore, it is possible to develop anticandidal medicine for decreases prescription drug price in other countries, decrease clotrimazole resistance, and increase Thai medicinal herb value.
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