Development of Eugenia grataExtract Film Strip for Oral Hygiene

Abstract

The purposes of this study were to develop polymeric film strips containing Eugenia grataextract with good physical characteristics (optimal thickness, easily peel from teflon plate and optimal fragility, strength, clarity and fast dissolution) and to test the activity of film strip containing E. grataagainst pathogenic bacteria in oral cavity using Disc-diffusion assay. The selected oral film strip consisted of 5% tacca : 5% pectin : 1.5% HPMC : 0.25% glycerin in the proportion of 1:1:1:0.25. The 5 mg/ml (double concentration of Minimum inhibitory concentration, MIC) E. grataextracts film strip inhibited Staphylococcus aureus, Streptococcus faecalis and Bacillus subtiliswith Inhibition zone of 9, 12 and 11 mm, respectively while the commercial film strip inhibited only B. subtilis.In conclusion, the film strip with E. grataextracts could effectively inhibit microbial growth in oral cavity and should be developed for commercial oral hygienic product.