Impact of Chronic Kidney Disease on the Risk of Death, Cardiovascular Events, and Hospitalization
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Abstract
Clinical and public health important of chronic kidney disease (CKD) in Thai patients are not well studied. This study aimed to examine associations between CKD and clinical outcomes. A retrospective cohort study was conducted in 1,220 adult outpatients whose serum creatinine had been measured between January 1, 2004 and April 30, 2004 at Mahasarakham Hospital. Stages of CKD were defined based on K/DOQI guideline using Cockroft and Gault formula. The primary endpoint was death from any causes. The secondary endpoints were cardiovascular events, and hospitalization. Kaplan-Meier plots, Cox proportional hazards model, and adjusted hazard ratios were used for analysis. Of all 1,220 patients with an average age of 54.68±14.17 years, 52.46% were women. The median follow-up was 2.86±10.26 years. A significant increase in hazard of death from any causes (61%), and hospitalization (13%) was corresponding with an increase in stage of CKD (p < 0.05). From adjusted hazard ratios, an increase in CKD-stages was not associated with significant increase in risk of death from any cause, cardiovascular event, and hospitalization.
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