AZF, SRY Microdeletions and Hormonal Disturbances among Azoospermic Iraqi men
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Abstract
Y chromosome microdeletions and hormonal disturbances were implicated in men infertility. This study
was conducted to investigate the AZF and SRY regions microdeletions and hormonal disturbance in 43 azoospermic and 20 healthy and fertile men. Twelve (27.9%) of azoospermic men have shown deletions with undetected chromosomal abnormalities. Five of these deletions have been detected in men with a history of post pubertal mumps. AZFc is recorded as the most frequent deleted region in azoospermic men. FSH and prolactin elevation levels were also detected in patients but with undistinguishable correlation parallel to the detected microdeletions.
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