Rate of Drug Interaction from Overriding Automatic Drug Interaction Warning System and from Different Prescriptions
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Abstract
Introduction :Although drug interaction (DI) pop-up was alert from automatic drug interactions warning system in the prescribing process, it can be overridden by the prescribers. In addition, it cannot detect DI from different prescriptions. The objectives of this study were to measure DIs with major and moderate severity in the same prescription and to identify DIs with major severity from different prescriptions. Methods: Out patient prescriptions from January 1 to December 2015 were searched for DIs from the same prescription and different prescriptions. Drug Interaction Facts® 2009 was used as a reference to identify and classify DIs with major and moderate severity. Data were analyzed by descriptive statistics. Results: Among 173,746 prescriptions, major and moderate severity DIs from the same prescription were observed in 1,379 (7.94 episodes/per 1,000 prescriptions)prescriptions and 11,516 (66.28episodes/per 1,000 prescriptions)prescriptions respectively. For DIs with major severity from different prescriptions, the most common was simvastatin and warfarin with a frequency of182episodes(13.47 episodes/per 1,000 prescriptions)from 13,511prescriptions.Conclusion:Although automatic DI warning is active in the prescribing process, DIs with major and moderate severity from overriding automatic DI warning system and DIs with major severity from different prescriptions were still observed.Therefore, monitoring system should be implemented to follow up these potential DIs to support patient safety
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