A Meta-analysis of the Efficacy of Cinnamon on blood glucose, lipid profile and anthropometric parameters : An updated literature review
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Abstract
Introduction: Cinnamon has been used as alternative medicine for reducing blood glucose, lipid lowering, and decrease anthropometric parameters. However, no summarization of all clinical effects and safety has been evaluated. Therefore, our study aimed to review literatures systematically and conduct the meta-analysis to confirm clinical efficacy of cinnamon. Methods: International and Thai databases were searched from inception through year 2016. Comparative randomized controlled trials (RCT) investigating oral cinnamon in human, written in English or Thai. Two independent authors evaluated title, abstract, quality of studies and extract data. Results: From 133 articles were identified, 15 trials involving 621 participants were included for efficacy analysis. The resulted showed statistically significant difference of efficacy in FBS (WMD -8.99 mg/dL; 95%CI -14.66, -3.31; p=0.002), LDL (WMD -10.05 mg/dL; 95%CI -18.12, -1.98; p=0.01) and TG (WMD - 7.03 mg/dL; 95%CI -12.56, -1.50; p=0.01). There were no statistically significant differences in anthropometric parameters. No serious adverse events from cinnamon had been found during the studies. Conclusion: This meta-analysis revealed that cinnamon may improve fasting blood glucose, lipid profile. However, the adverse side effect and safety should be concerned. A large, well-designed RCT using a standardized preparation of cinnamon will provide definitive data on specific participants.
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References
Akilen R, Tsiami A, Devendra D, Robinson N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet Med. 2010; 27(10): 1159-67.
Allen RW, Schwartzman E, BakerWL, Coleman CI, Phung OJ. Cinnamon Use in Type 2 Diabetes: An UpdatedSystematic Review and Meta-Analysis. Ann Fam Med. 2013; 11(5): 452-9.
Altschuler JA, Casella SJ, MacKenzie TA, et al. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care. 2007; 30(4): 813-6
Anand P, Murali KY, Tandon V, Murthy PS, Chandra R. Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats. Chem Biol Interact. 2010; 186(1): 72-81.
Anderson RA: Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc. 2008; 67: 48y53.
Beejmohun V, Peytavy-Izard M, Mignon C, Muscente-Paque D, Deplanque X, Ripoll C, et al. Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteers. BMC Complement Altern Med. 2014;14: 351-9.
Blevins SM, Leyva MJ, Brown J, Wright J, Scofield RH, Aston CE. Effect of cinnamon on glucose and lipid levels in non-insulin-dependent type 2 diabetes. Diabetes Care. 2007; 30(9): 2236-7.
Cao H, Polansky MM, Anderson RA. Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. Arch Biochem Biophys. 2007 ;459: 214y22.
Chapman MJ, Ginsberg HN, Amarenco P, et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J. 2011; 32: 1345-61.
Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med. 2009; 22(5): 507-12.
Davidson JA, Parkin CG, et al. Is hyperglycemia a causal factor in cardiovascular disease? Diab Care. 2009; 32: s331ds333
Davis PA, Yokoyama W. Cinnamon Intake Lowers Fasting Blood Glucose: Meta-Analysis. J Med Food. 2011; 14(9): 884y9.
Higgins JPT, Thomson SG, Deeks JJ, AltmanDG. Measuring inconsistency in meta analyses.BMJ.2003; 327: 557-60.
Huang B, Yuan HD, Kimdo Y, Quan HY, Chung SH. Cinnamaldehyde prevents adipocyte differentiation and adipogenesis via regulation of peroxisome proliferator-activated receptor-gamma (PPARgamma) and AMP-activated protein kinase (AMPK) pathways. J Agric Food Chem. 2011; 59: 3666y73.
Jadad AR, Moore RA, Carroll D, Jenkison C, et al. Assessing the Quality of Randomize Controlled trials: IS Blinding Necessary. Elscvier Seience Inc. 1996; 17: 1-12.
Jin S, Cho KH. Water extracts of cinnamon and clove exhibits potent inhibition of protein glycation and antiatherosclerotic activity in vitro and in vivo hypolipidemic activity in zebrafish. Food Chem Toxicol. 2011; 49: 1521-29.
Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003; 26(12): 3215-8.
Lu T, Sheng H, Wu J, et al. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012; 32(6): 408-12.
Mang B, Wolters M, Schmitt B, et al. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 2006; 36(5): 340-4.
Ministry of Public Health, Bureau of Non Communicable Disease. Annual Report 2015.searching http://thaincd.com/document/file/download/paper-manual/Annual-report-2015. Access: Jan 28, 2017.
Mollazadeh H, Hosseinzadeh H. Cinnamon effects on metabolic syndrome: a review based on its mechanisms. Iran J Basic Med Sci. 2016; 19: 1258-70.
Qin B, Polansky MM, Anderson RA: Cinnamon extract regulates plasma levels of adipose-derived factors and expression of multiple genes related to carbohydrate metabolism and lipogenesis in adipose tissue of fructose-fed rats. Horm Metab Res. 2010; 42: 187y93.
RA Ahmad, H Serati-Nouri, FAA Majid, et al. Assessment of Potential Toxicological Effects of Cinnamon Bark Aqueous Extract in Rats. International Journal of Bioscience, Biochemistry and Bioinformatics. 2015.
Ranasinghe P, et al. Medicinal properties of “true” cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complementary and Alternative Medicine. 2013; 13: 275.
Roussel AM, Hininger I, Benaraba R, et al. Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. J Am Coll Nutr. 2009; 28(1): 16-21.
Serban C, Sahebkar A, Ursoniu S, Andrica F, Banach M. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2015; 33(6): 1119-27.
Shen Y, Honma N, Kobayashi K, Jia LN, Hosono T, Shindo K, et al. Cinnamon extract enhances glucose uptake in 3T3-L1 adipocytes and C2C12 myocytes by inducing LKB1-AMP-activated protein kinase signaling. PLoS One. 2014; 9:e87894.
Sheng X, Zhang Y, Gong Z, Huang C, Zang YQ. Improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptors. PPAR Res. 2008; 581348.
Singh G, Maurya S, DeLampasona MP, Catalan CA: A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food Chem Toxicol. 2007; 45: 1650y61.
Tang M, Larson-Meyer DE, Liebman M. Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects 1,2,3. Am J Clin Nutr. 2008; 87(5): 1262-67
Ulbricht C, Seamon E, Windsor RC, et al. An Evidence-Based Systematic Review of Cinnamon (Cinnamomum spp.) by the Natural Standard Research Collaboration. Journal of Dietary Supplements. 2011; 8(4): 378y454.
Vanschoonbeek K, Thomassen BJ, Senden JM, Wodzig WK, van Loon LJ. Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr. 2006; 136(4): 977-80.
Wainstein J, Stern N, Heller S, et al. Dietary Cinnamon Supplementation and Changes in Systolic Blood Pressure in Subjects with Type 2 Diabetes. J Med Food. 2011; 14(12): 1505-10.
Wickenberg J, Lindstedt S, Nilsson J, et al. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutrition Journal. 2014; 13:96: DOI: 10.1186/1475-2891-13-96
Ziegenfuss TN, Hofheins JE, Mendel RW, et al. Effects of a Water-Soluble Cinnamon Extract on Body Composition and Features of the Metabolic Syndrome in Pre-Diabetic Men and Women. J Int Soc Sports Nutr. 2006; 3(2): 45y53.