Development of Theophylline Orodispersible Film Fabricated by 2D Printing Technique
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Abstract
Introduction: Medicine printing is one of the technologies which has been applied to prepare the pharmaceutical product. This precise technology can scale the size of medicine. Therefore, researchers are interested in this technology to develop the orodispersible film. Methods: In this study, seed gum from Tamarindus Indica Linn was selected to use as film former and sorbitol was used for plasticizing purpose. Theophylline was chosen as a printed model drug. Results: The results of the film mechanical properties indicated that increasing of sorbitol enhanced film flexibility. On the other hand, increasing gum portion leaded to tough and stress film. The proper amount of gum and sorbitol to prepare film is 3.5 % w/w gum and 97:3 sorbitol. The FTIR result revealed that there was no interaction between theophylline and gum after printing process. Drug loading study expressed that printing technology is very precise since the loaded drug on films accurately increased when the drug printing was repeated. Moreover, the in vitro drug release from the drug printed film reached 80% of total drug release within 3 minutes. Conclusion: These results showed that the gum from tamarind seed shine possibility of the gum film application to be potential printing substrate for the 2D printing technology.
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