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Introduction: Curcuma comosa Roxb. has been used for treatment a wide range of women reproductive disorders in Thai folk medicine because it contains phytoestrogens. Currently, it has been studied several bioactives. However, the extract has been reported the low bioavailability with some adverse effects by oral administration. Nanostructured lipid carriers (NLC) is the delivery system compatible with the lipophilic extract. The objectives of this study were to optimize the NLC compositions and study their stabilities. Methods: NLC was developed and determined the particle size, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency, loading capacity and thermal analysis. The obtained formulations were kept at 4, 25 and 40 ºC for 180 days, and then were investigated the particle characterization and drug quantity. Results: The optimized formulation contained 2.5 %w/w surfactant, 30 %w/w of liquid lipid in lipid phase and 7.5 %w/w lipid phase in formulation. The particle size, PDI, ZP and %EE of the blank and incorporated-NLC were 200 d 225 nm, 0.215 - 0.0270, -30 mV and over 90 % EE, respectively. The NLC showed amorphous property and good stability. Conclusion: Nanostructured lipid carriers is appropriate to encapsulate C. comosa extract with small particle size and good stability.
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