Effects of Liquid lipid and Solid Lipid on Physical Characteristics Particle Size Zeta-potential Viscosity pH of Nanostructured Lipid Carriers (NLCs) Fabrication
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Abstract
Introduction: The aim of this study is to study the effect of liquid lipid and solid lipid on Nanostructured Lipid Carriers (NLCs) preparations. NLCs is useful for insoluble water and less permeation soluble drug delivery for topical spray formulation development. Methods: NLCs was prepared by mixing the melted liquid lipid and solid lipid at 85 degree celsius with high speed homogenizer and probe sonicator. MCT and compritol® 888ATO were used as the liquid lipid (LL) and solid lipid (SL), respectively. Tween® 80 was also used surfactant at 3% and total lipid concentration at 6, 9 and 12% with ratio of LL to SL 1:2 and 1:4 were also investigated. The physical appearance, particles size, polydispersity index (PDI), zeta potential, viscosity and pH were evaluated in all formulations. Results: Nanostructure Lipid carrier colloidal solutions. The average particle size range between 154.5±0.74 nm and 923.8±0.62 nm (PDI less than 0.3) with a low viscosity. Zeta potential was shown in range of -13.8 to -23.4 mV In addition, low viscosity. The value of pH was about 5 to 6 in all formulations so it is applicable for skin application. Conclusion: NLCs formulation with total lipid concentration 6% total lipid in ratio LL:SL 1:2 with Tween® 80 surfactant used suitable for nanostructure lipid carriers preparation for topical spray formulation development.
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