Development of finasteride proniosomes for transfollicular delivery
Article Sidebar
Main Article Content
Abstract
Introduction: Transfollicular route is one of the most interesting and important routes for the treatment of skin conditions especially in hair loss, since the target organ of such diseases are located around this area. Moreover, delivery of drug through transfollicular route can reduce side effect. Currently, the U.S. Food and Drug Administration has approves finasteride as tablets used for the treatment of male pattern hair loss. Despite no finasteride available in topical dosage form. The purpose of this research was to develop finasteride proniosomes for transfollicular delivery that may give comparables efficacy to minoxidil solution and can reduce side effect of oral dosage form. Material and method: Finasteride proniosomes were prepared by coacervation phase separation method. In vitro drug release study was performed by dialysis test and transfollicular delivery of finasteride proniosomes was tested by follicular closing technique. Stability test was performed under controlled condition for 4 months. Results: Release rate of finasteride proniosomes was released in a sustained release manner than that of finasteride solution (ethanol:phosphate buffer 1:1) due to the control release property of proniosmes. Finasteride proniosomes and finasteride solution could penetrated through transfollicular was 2.43 ± 0.63 µg/cm2 and 0.67 ± 0.91 µg/cm2, respectively. The low partition coefficient of finasteride and sebum produce in tranfollicular route that favour the transport of drug from proniosmes was better than that of the solution form. The percentage of encapsulation efficiency and drug loading capacity after stored for 4 months was 86% and 12%, respectively. Particles size was 300-340 nm with an average particle size distribution in the range 0.437±0.041 and was comparable to finasteride proniosomes freshly prepared (p> 0.05). Conclusion: Development of finasteride proniosomes with particles size in rang 300-340 nm could be delivery through transfollicular route. The particles size and physical characterization of finasteride proniosomes remained stable for 4 months.
Article Details
In the case that some parts are used by others The author must Confirm that obtaining permission to use some of the original authors. And must attach evidence That the permission has been included
References
Alexa P, Funny K, Wolfram S, et al. Hair follicles, their disorders and their opportunities. Drug Discovery Today: Disease Machanisms 2008; 173-180.
Almira I, Blazek, W, Rhodes, DG. Maltodextrin based proniosomes. AAPS PharmSciTech 2001; 3(1): 1-7.
Andrea CL, Linda ML, Gordon LF, et al. Transfollicular drug delivery. Pharm Res 1995; 12(2): 179-186.
Behrooz N. Effect of cholesterol and temperature on the elastic properties of niosomal membranes. Int J Pharm 2005;300(1-2): 95 -101.
Bharti N, Loona S, Khan MM. Proniosomes: A recent advancement in nanotechnology as a drug carrier. Int J Pharm Sci 2012;12(1):67-75.
Mohamed MN, Labiba KK, Nawal K. Release stability of 5 -fluorouracil liposomal concentrates, gel and lyophilized powder. Acta Pol Pharm 2005;62(5):381-391.
Pillai GK, Salim MLD. Enhanced inhibition of platelet aggregation in vitro by niosome-encapsulated indomethacin. Int J Pharm 1999;193(1):123-127.
Price VH. Treatment of hair loss. N Engl J Med 1999;341(13):964–973.
Rogers NE, Avram MR. Medical treatments for male and female pattern hair loss. J Am Acad Dermatol 2008; 59(4): 547-566.
Teichmann A, Otberg N, Jacobi U, et al. Follicular penetration: development of a method to block the follicles selectively against the penetration of topically applied substances. Skin Pharmacol Physiol 2006; 19: 216–23.
Ulrike BP, Massoudy L, Patzelt A, et al. Follicular and percutaneous penetration pathways of topically applied minoxidil foam. Eur J Pharm Biopharm 2010;76(3):450-453.
Varaporn BJ, Veerawut T, Tasaneeya S. Effect of charged and non-ionic membrane additives on physicochemical properties and stability of niosomes. AAPS PharmSciTech 2008;9(3):851-859.
Van ND, Fuh V, Lopez-Bran E, et al. Finasteride increases anagen hair in men with androgenic alopecia. J Dermatol 2000;143:804-810.
Ylva YG, Whitehead L, Cornwell P, et al.Time and depth resolved visualisation of the diffusion of a lipophilic dye into the hair follicle of fresh unfixed human scalp skin. J Control Release 2004;98(3):367-378.