Anti-gastric erosion effect of brassica juncea extract in rats

Main Article Content

จารุวัฒน์ บุญวิจิตร
กิตติศักดิ์ ศรีพานิชกุลชัย
บังอร ศรีพานิชกุลชัย
วนัสนันท์ แป้นนางรอง
มาลาภรณ์ วิชัย

Abstract

The present study was designed to investigate the effect of Brassica juncea against acidified alcohol (150 mM HCl : Absolute EtOH 40:60 v/v) induced gastritis. The experimental groups were pre-treated with B. juncea extract at concentrations of 125, 250, and 500 mg/kgBW. Positive control group was pre-treated with 20 mg/kgBW of Omeprazole. The results showed that the negative control group that was given HCl/EtOH only had an ulcer area of 0.080.04 mm2. In normal group was received DW have a ulcer area 0.014 mm2. Pre-treated with B. juncea extract can reduce ulcer area when compared with negative control group. From the results, it is concluded that pre-treated with B. juncea extract can decrease an ulcer area induced by HCl/EtOH

Downloads

Download data is not yet available.

Article Details

Section
Appendix

References

Al- Amin, Sultana, Hossain. Antiulcer principle from Zingiber montanum. Journal of Ethnopharmacology 2012.
AlRashdi, Salama, Alkiyumi et al. Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HCl/Ethanol-Induced Gastric Mucosal Injury in Rats. Evidence-Based Complementary and Alternative Medicine 2012, Article ID 786426.
Ariane Leite Rozza, Thiago de Mello Moraes, Helio Kushima et al. Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and itsmajority compounds limonene and β-pinene: Involvement of heat -shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E2. Chemico-Biological Interactions 2011.
Deoda, Kumar, and Bhujbal.Gastroprotective Effect of Rubia cordifolia Linn. on Aspirin Plus Pylorus-Ligated Ulcer. Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 541624.
Matsuda, Kubo : Pharmacological study on Panax ginseng C. A. Meyer. II. Effects of red ginseng on the experimental gastric ulcer (1).Yakugaku Zasshi 1984.
Oyagi, Ogawa, Kakino et al. Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. BMC Complementary and Alternative Medicine 2010.
Pannangpetch P, Watanathorn J, Phasuriwong O et al. Antigastric ulcer effect of Tumaric in rats. Srinagarind Med J 2000.
Rujjanawate C, Kanjanapothi D, Amornlerdpison S et al. Anti- gastric ulcer effect of Kaempferia parviflora. J Ethnopharmacal 2005.
Sripanidkulchai k, Techataweewan N, Tumsan Yet al.Prevention of Indomethacin-induced gastric ulcers in rats by extract from leaves of Centella asiatica. Journal of medicinal food 2009.
Sripanidkulchai k, Teepsawang S, Sripanidkulchai B.Protective effect of Cratoxylum formosum extract against acid/alcohol-induced gastric mucosal damage in rats. Siriraj Med J 2
Suffredini, Bacchi, Sertie. Antiulcer action of Microgramma squamulosa (Kaulf.) Sota. Journal of Ethnopharmacology 1999.
Thong-Ngam D, Choochuai S, Patumraj S et al. Curcumin prevents indomethacin-induced gastropathy inRats. World J Gastroenterol2012.
Umamaheswari, Asokkumar, Rathidevi et al. Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L. Journal of Ethnopharmacology 2007.
Vasudeva, Sethi, Sharma et al. Antiulcer Potential of the Ethanolic Extract of Aerva Persica Merrill Root in Rats. Journal of Acupuncture and Meridian Studies 2012.
Vivek Pandey et al. Antioxidative responses in relation to growth of mustard (Brassica juncea cv. Pusa Jaikisan) plants exposed to hexavalent chromium. Chemosphere 2005.