The Study of Modified Glutinous Rice Starch as a Filler-Binder for Direct Compression Tablets

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Pornpun Laovachirasuwan
Voranuch Srijesdaruk
Padungkwan Chitropas
Makoto Otsuka
Jomjai Peerapattana


Introduction: Glutinous rice starch (GRS) is insoluble in cold water, small size and polyhedral shape which giving the low flowability and compressibility properties. Methods: The Spray dried glutinous rice starch (SGRS) was prepared by heating and then spray drying. The SGRS has increased in the particle size and concave spherical shape which affect to increasing flowability and compressibility properties. The SGRS used as filler-binder in direct compression tablets compared with microcrystalline cellulose (MCC), Hydroxypropyl methylcellulose (HPMC), Starch 1500®, Era Gel®, Era Pac®. The characterization of direct compression tablets contained propranolol hydrochloride such as weight variation, thickness, hardness, friability, disintegration time and in vitro dissolution were determined. Results: Only the formulations with SGRS, MCC, HPMC, and Starch 1500® were passed the criteria of tablet characteristics.  The in vitro dissolution of the formulation with SGRS and HPMC were slowly dissolved. The various content of SGRS and HPMC were investigated. The results showed that only the formulations with more than 5% HPMC and more than 40% SGRS could be sustained release the drug. Conclusion: The SGRS could be used as a filler-binder and sustained release agent for direct compression tablets. Therefore, it is beneficial to increase the value and application usage of SGRS in pharmacy.

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