Allelic frequency and genotype distributions of angiotensin converting enzyme gene among three essential Iraqi ethnic group population

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DOI: https://doi.org/10.14456/ijps.2012.3
Keywords:
ACE (angiotensin-converting enzyme) ACE polymorphism. Iraqi Ethnics group

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Salwa J. Al-Awadi
Assist. Prof. Ph.D. in Medical Molecular genetics, Genetic Engineering and Biotechnology Institute, Baghdad University, Baghdad, Jaderyah, Iraq.
Abdulameer M. Ghareeb
MSc. In Biotechnology, Genetic Engineering and Biotechnology Institute, Baghdad University, Iraq, Baghdad, Jaderyah, Iraq
Wisam H. Salo
MSc. In Biotechnology, Genetic Engineering and Biotechnology Institute, Baghdad University, Iraq, Baghdad, Jaderyah, Iraq

Abstract

Human angiotensin-converting enzyme (ACE) gene has an insertion-deletion (I/D) polymorphic whichproduce three allelic variants: II, ID & DD that associated with many genetic disease. ACE gene polymorphisms have been studied in different ethnic populations. The polymorphisms of ACE gene were investigated using polymerase chain reaction to detect the I/D mutation in a total of 191 healthy individual’s sample selected randomly from northern and central Iraqi ethnics groups: Arab, Kurd and Turkman. The results showed a high D allele frequency in Arab population (D 65.5%, I 34.5%), high I allele frequency in Kurd population (D 42.3%, I 57.7%), while an equal value of D and I (50%) in Turkman population. Allele frequency D and I was calculated according to the Hardy-Weinberg equilibrium. The DD, ID and II genotypes distribution were observed in Iraqi ethnic groups as: 50 (50%), 31 (31%) and 19 (19%) in Arab population and 10 (20%), 24 (46%) and 18 (34%) in Kurd population while the result showed 12 (30.7%), 15 (38.4%) and 12 (30.7%) in Turkman population, respectively. We conclude from this study that the frequency of ACE gene polymorphic are different in the main populations of Iraq.

Article Details

Issue
Vol. 8 No. 1 (2012): Volume 8 No.1 January - Apirl, 2012
Section
Pharmaceutical Sciences

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