Pharmaceutical Uses of Polyelectrolyte Complexes
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Abstract
Since the 1990s, drug delivery technologies have developed extensively, including systems utilizing polyelectrolyte complexes. In this technology, the system is formed by oppositely charged molecules, resulting in the precipitation of small particles. Polyelectrolyte complexes are divided into two groups: polyelectrolyte-polyelectrolyte (PE-PE) and polyelectrolyte-surfactant (PE-Surf). Herein, PE-PE is focused upon. In this review article, theories of formation, factors influencing complexation, particularly, the effects of salt, polymer structure, temperature, and mixing ratios are mentioned. Moreover, evaluation of the interaction between polyelectrolytes, the uses in the pharmaceutical arena, for example, the delivery of vancomycin for colon targeting, the uses of PE-PE as membranes or thin films for coating and the cytotoxicity of PE-PE are discussed.
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