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Introduction: Lipase is an enzyme secreted from the pre-duodenal (ligual and gastric) and the extra-duodenal (pancreatic, hepatic, lipoprotein and endothelial), which can digest fat, phospholipids and triacylglycerol. This enzyme plays a role for the hydrolysis of 50-70% of total dietary fat before absorption and acts as source of energy. Objective: The aim of this study was to investigate new pancreatic lipase inhibitor from Crataeva magna (Kum-nam). Materials and method: The ethanolic extract of Kum-nam was screened for anti-lipase activity by using porcine pancreatic lipase assay. P-nitrophenylbutyrate was used as the substrate. Results: It was found that, Crataeva magna extract showed an anti-lipase activity with the IC50 of 801.17 µg/mL, while IC50 of Orlistat, positive control was 0.68 µg/mL. The anti-lipase activity mechanism was mixed inhibition. Conclusion: Although, anti-lipase activity of Kum-nam was lower than Orlistat, further study of this plant should be conducted.
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