A Systematic review and Meta-analysis efficacy of Gynostemma pentaphyllum (Thunb.) Markino on Blood glucose, lipid profile, blood pressure and anthropometric parameters
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Abstract
Introduction: Cardiovascular disease caused by hyperglycemia, hyperlipidemia hypertension and obesity. Gynostemma pentaphyllum is a medicinal plant which has reportedly affected on blood glucose, lipid profile lowering, decrease blood pressure and decrease anthropometric parameters. However, there were no clearly clinical efficacy evidences of G. pentaphyllum. The objectives of this study wereto review literatures systematically and conduct the meta-analysis to confirm clinical efficacy of G. pentaphyllum. Methods: Published articles were searched from electronic databases including Pubmed, Science-Direct, Scopus, SciSearch and ThaiLIS as well as hand search. Studies with randomized controlled trial design in human, written in English or Thai, and conducted until 2015 were recruited into the study. Two independent authors evaluated title, abstract, quality of studies and extract data. Results: Four publications met inclusion criteria with high quality of methodology with Jadad’s score. The number of participants in the studies ranged from 16-80. Three studies were conducted in Vietnam and one study was performed in South Korea. The resulted showed statistically significant difference of efficacy in glycemic control between G. pentaphyllum and comparators; FBS (WMD -1.17 mmole/L; 95%CI -1.63, -0.71; p<0.001), HbA1c (WMD -1.10%; 95%CI -1.61, -0.59; p<0.001), HOMA-IR (WMD -2.21; 95%CI -4.36, -0.07; p=0.04). There were no statistically significant differences in blood lipid, blood pressure, and anthropometric parameters. No serious ADR from G. pentaphyllum had been found during the studies. Conclusion: This study suggests that G. pentaphyllum expresses blood glucose lowering effect. This suggests that G. pentaphyllum can be used as an alternative for glycemic control. However, the adverse side effect and safety should be concerned and a randomized control trial is stillneeded in order to confirm other clinical outcomes and safety of G. pentaphyllum.
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