Development of Body Lotions Prepared from `Puag-Haad´
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Abstract
Introduction: Puag-Haad, the light brown powder, was prepared by extracting of Artocarpus
lakoocha heartwood with boiling water. It contains high content of oxyresveratrol which possess many
pharmacological effects. Objective: The aim of this study was to develop the body lotions from Puag-Haad.
Methods: TLC-densitometric method was used to determine the concentration of oxyresveratrol in Puag-
Haad. Effect of Puag-Haad on enzyme tyrosinase activity was investigated by Dopachrome method. Body
lotions from Puag-Haad was formulated by using beaker method. Finally, the developed formulations were
characterized including stability test, irritation study, moisturizing effect, and whitening effect in healthy
volunteers (n = 2 9 ) after applied the lotion for four weeks. Results: The result showed that Puag-Haad
contained 0.94±0.05 g of oxyresveratrol/g of Puag-Haad. It inhibited tyrosinase enzyme activity with IC50 of
15.40±1.47 μg/mL. Then, the body lotions from Puag-Haad (0.1%) were developed. The formulation with
triethanolamine stearate as emulsifying agent was successful. It had physicochemical stability after stability
study by heating/cooling method including smooth texture, no cracking, good flavor, no change of color, and
pH at 6-7. All volunteers who applied the developed lotion had no irritation and they satisfied with the lotion.
The result of melanin content in skin in healthy volunteers who had no interruption from other factors were
significantly decreased (P<0.05) after used the developed lotion for 4 weeks. Moreover, skin moisturizing of
the volunteers was significantly increased at P<0 .0 5 after used the developed lotion for 4 weeks.
Conclusion: The body lotion from Puag-Haad (0 .1% w/w) had whitening effect and moisturizing of skin.
Moreover, it had also no report of skin irritation.
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References
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